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• W2102629981 abstract "The long-term effects of uncoupled mitochondrial respiration by uncoupling protein-2 (UCP2) in mammalian physiology remain controversial. Here we show that increased mitochondrial uncoupling activity of different tissues predicts longer lifespan of rats compared with mice. UCP2 reduces reactive oxygen species (ROS) production and oxidative stress throughout the aging process in different tissues in mice. The absence of UCP2 shortens lifespan in wild-type mice, and the level of UCP2 positively correlates with the postnatal survival of superoxide dismutase-2 mutant animals. Thus UCP2 has a beneficial influence on cell and tissue function leading to increased lifespan." @default.
• W2102629981 created "2016-06-24" @default.
• W2102629981 creator A5003734252 @default.
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• W2102629981 date "2009-04-01" @default.
• W2102629981 modified "2023-10-17" @default.
• W2102629981 title "Uncoupling protein-2 regulates lifespan in mice" @default.
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• W2102629981 doi "https://doi.org/10.1152/ajpendo.90903.2008" @default.
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