FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102657713> ?p ?o ?g. }

• W2102657713 endingPage "1656" @default.
• W2102657713 startingPage "1651" @default.
• W2102657713 abstract "Objective— The endothelium-derived fibrinolytic factor tissue plasminogen activator (t-PA) is a major determinant of vessel patency after coronary plaque rupture and thrombosis. We assessed whether endothelial fibrinolytic capacity predicts atherothrombotic events in patients with coronary heart disease. Methods and Results— Plasma t-PA and plasminogen activator inhibitor (PAI)-1 concentrations were measured during intrabrachial substance P infusion in 98 patients with angiographically proven stable coronary heart disease. Forearm blood flow was measured during infusion of substance P and sodium nitroprusside. Cardiovascular events (cardiovascular death, myocardial infarction [MI], ischemic stroke [CVA], and emergency hospitalization for unstable angina) were determined during 42 months of follow-up. Patients experiencing a cardiovascular event (n=19) had similar baseline characteristics to those free of events. Substance P caused a dose-dependent increase in plasma t-PA concentrations ( P <0.001). However, net t-PA release was 72% lower in the patients who experienced death, MI, or CVA, and 48% lower in those who suffered death, MI, CVA or hospitalization for unstable angina ( P <0.05). Major adverse cardiovascular events were most frequent in those with the lowest fibrinolytic capacity ( P =0.03 for trend); patients with the lowest quartile of t-PA release had the highest rate of adverse events ( P =0.01). Conclusion— Endothelial fibrinolytic capacity, as measured by stimulated t-PA release, predicts the future risk of adverse cardiovascular events in patients with coronary heart disease. We suggest that endothelial fibrinolytic capacity is a powerful novel determinant of cardiovascular risk." @default.
• W2102657713 created "2016-06-24" @default.
• W2102657713 creator A5017523544 @default.
• W2102657713 creator A5033224816 @default.
• W2102657713 creator A5042777389 @default.
• W2102657713 creator A5074252129 @default.
• W2102657713 date "2007-07-01" @default.
• W2102657713 modified "2023-10-09" @default.
• W2102657713 title "Endothelial Fibrinolytic Capacity Predicts Future Adverse Cardiovascular Events in Patients With Coronary Heart Disease" @default.
• W2102657713 cites W1500453306 @default.
• W2102657713 cites W1968319785 @default.
• W2102657713 cites W1999209170 @default.
• W2102657713 cites W2007129904 @default.
• W2102657713 cites W2014753430 @default.
• W2102657713 cites W2016918804 @default.
• W2102657713 cites W2017587402 @default.
• W2102657713 cites W2019338486 @default.
• W2102657713 cites W2021577809 @default.
• W2102657713 cites W2022321345 @default.
• W2102657713 cites W2030098179 @default.
• W2102657713 cites W2037383079 @default.
• W2102657713 cites W2050527278 @default.
• W2102657713 cites W2074201999 @default.
• W2102657713 cites W2086811058 @default.
• W2102657713 cites W2088383697 @default.
• W2102657713 cites W2099683917 @default.
• W2102657713 cites W2116809428 @default.
• W2102657713 cites W2117334568 @default.
• W2102657713 cites W2129092071 @default.
• W2102657713 cites W2129149737 @default.
• W2102657713 cites W2139480984 @default.
• W2102657713 cites W2140853784 @default.
• W2102657713 cites W2141470773 @default.
• W2102657713 cites W2163815180 @default.
• W2102657713 cites W2330126172 @default.
• W2102657713 cites W2335455113 @default.
• W2102657713 cites W2336267479 @default.
• W2102657713 cites W2339639271 @default.
• W2102657713 cites W2401280047 @default.
• W2102657713 cites W2408827769 @default.
• W2102657713 cites W2463713668 @default.
• W2102657713 cites W635046673 @default.
• W2102657713 doi "https://doi.org/10.1161/atvbaha.107.143248" @default.
• W2102657713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17463331" @default.
• W2102657713 hasPublicationYear "2007" @default.
• W2102657713 type Work @default.
• W2102657713 sameAs 2102657713 @default.
• W2102657713 citedByCount "54" @default.
• W2102657713 countsByYear W21026577132012 @default.
• W2102657713 countsByYear W21026577132013 @default.
• W2102657713 countsByYear W21026577132014 @default.
• W2102657713 countsByYear W21026577132015 @default.
• W2102657713 countsByYear W21026577132016 @default.
• W2102657713 countsByYear W21026577132018 @default.
• W2102657713 countsByYear W21026577132020 @default.
• W2102657713 countsByYear W21026577132021 @default.
• W2102657713 countsByYear W21026577132022 @default.
• W2102657713 crossrefType "journal-article" @default.
• W2102657713 hasAuthorship W2102657713A5017523544 @default.
• W2102657713 hasAuthorship W2102657713A5033224816 @default.
• W2102657713 hasAuthorship W2102657713A5042777389 @default.
• W2102657713 hasAuthorship W2102657713A5074252129 @default.
• W2102657713 hasBestOaLocation W21026577131 @default.
• W2102657713 hasConcept C126322002 @default.
• W2102657713 hasConcept C127413603 @default.
• W2102657713 hasConcept C164705383 @default.
• W2102657713 hasConcept C197934379 @default.
• W2102657713 hasConcept C2777785093 @default.
• W2102657713 hasConcept C2778198053 @default.
• W2102657713 hasConcept C2778213512 @default.
• W2102657713 hasConcept C2778425758 @default.
• W2102657713 hasConcept C2779679481 @default.
• W2102657713 hasConcept C2780645631 @default.
• W2102657713 hasConcept C2780868729 @default.
• W2102657713 hasConcept C500558357 @default.
• W2102657713 hasConcept C71924100 @default.
• W2102657713 hasConcept C78519656 @default.
• W2102657713 hasConceptScore W2102657713C126322002 @default.
• W2102657713 hasConceptScore W2102657713C127413603 @default.
• W2102657713 hasConceptScore W2102657713C164705383 @default.
• W2102657713 hasConceptScore W2102657713C197934379 @default.
• W2102657713 hasConceptScore W2102657713C2777785093 @default.
• W2102657713 hasConceptScore W2102657713C2778198053 @default.
• W2102657713 hasConceptScore W2102657713C2778213512 @default.
• W2102657713 hasConceptScore W2102657713C2778425758 @default.
• W2102657713 hasConceptScore W2102657713C2779679481 @default.
• W2102657713 hasConceptScore W2102657713C2780645631 @default.
• W2102657713 hasConceptScore W2102657713C2780868729 @default.
• W2102657713 hasConceptScore W2102657713C500558357 @default.
• W2102657713 hasConceptScore W2102657713C71924100 @default.
• W2102657713 hasConceptScore W2102657713C78519656 @default.
• W2102657713 hasIssue "7" @default.
• W2102657713 hasLocation W21026577131 @default.
• W2102657713 hasLocation W21026577132 @default.
• W2102657713 hasOpenAccess W2102657713 @default.
• W2102657713 hasPrimaryLocation W21026577131 @default.
• W2102657713 hasRelatedWork W1574348006 @default.
• W2102657713 hasRelatedWork W1976744539 @default.

• next