Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102661292> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2102661292 abstract "Mutations of the adenomatous polyposis coli gene protein (APC) are associated with familial polyposis and also sporadic colon adenomas, both preconditions to cancer formation. Some familial polyposis patients also develop Gardner's syndrome, a condition characterized by supernumerary teeth, mandibular osteomas, and other maladies. We investigated participation of APC in normal tooth development. Using a monoclonal antibody to study APC expression in the forming rat incisor, we found no APC staining in differentiating ameloblasts, then strong staining in secreting ameloblasts and stratum intermedium cells, followed by cells in the transition stage which did not stain. Intense APC staining resumes in maturation-stage ameloblasts and proximal papillary cells. APC staining disappears again in reduced ameloblasts at the conclusion of amelogenesis. APC staining was not seen in any other odontogenic cells. We report a unique system in which APC expression is upregulated and downregulated twice during the normal life cycle of ameloblasts. APC, therefore, is important in the normal maturation of both colonic epithelium and odontogenic epithelium. At this point, we cannot rule out any of the known functions of APC, which include: modulation of cell adhesion by binding to catenin, regulation of beta-catenin as a differentiative signaling molecule, and promotion of microtubule assembly. In this respect, the rat incisor enamel organ provides a unique tissue for studying the regulation and functions of APC." @default.
- W2102661292 created "2016-06-24" @default.
- W2102661292 creator A5001937322 @default.
- W2102661292 creator A5017036398 @default.
- W2102661292 creator A5025535182 @default.
- W2102661292 creator A5039825740 @default.
- W2102661292 date "1998-12-01" @default.
- W2102661292 modified "2023-09-26" @default.
- W2102661292 title "Adenomatous Polyposis Coli Protein is Expressed in Alternate Stages of the Ameloblast Life Cycle" @default.
- W2102661292 cites W153332747 @default.
- W2102661292 cites W1534652806 @default.
- W2102661292 cites W1881022503 @default.
- W2102661292 cites W1967921405 @default.
- W2102661292 cites W2011812152 @default.
- W2102661292 cites W2015808843 @default.
- W2102661292 cites W2029247990 @default.
- W2102661292 cites W2032345748 @default.
- W2102661292 cites W2039375742 @default.
- W2102661292 cites W2050750704 @default.
- W2102661292 cites W2055971769 @default.
- W2102661292 cites W2062911730 @default.
- W2102661292 cites W2066153615 @default.
- W2102661292 cites W2070168194 @default.
- W2102661292 cites W2093531978 @default.
- W2102661292 cites W2156545498 @default.
- W2102661292 cites W4247816276 @default.
- W2102661292 doi "https://doi.org/10.1177/00220345980770120501" @default.
- W2102661292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9839785" @default.
- W2102661292 hasPublicationYear "1998" @default.
- W2102661292 type Work @default.
- W2102661292 sameAs 2102661292 @default.
- W2102661292 citedByCount "13" @default.
- W2102661292 countsByYear W21026612922012 @default.
- W2102661292 countsByYear W21026612922013 @default.
- W2102661292 countsByYear W21026612922016 @default.
- W2102661292 countsByYear W21026612922020 @default.
- W2102661292 crossrefType "journal-article" @default.
- W2102661292 hasAuthorship W2102661292A5001937322 @default.
- W2102661292 hasAuthorship W2102661292A5017036398 @default.
- W2102661292 hasAuthorship W2102661292A5025535182 @default.
- W2102661292 hasAuthorship W2102661292A5039825740 @default.
- W2102661292 hasConcept C104392178 @default.
- W2102661292 hasConcept C121608353 @default.
- W2102661292 hasConcept C142724271 @default.
- W2102661292 hasConcept C156887251 @default.
- W2102661292 hasConcept C176860957 @default.
- W2102661292 hasConcept C199106506 @default.
- W2102661292 hasConcept C199343813 @default.
- W2102661292 hasConcept C2778237340 @default.
- W2102661292 hasConcept C2780814781 @default.
- W2102661292 hasConcept C502942594 @default.
- W2102661292 hasConcept C526805850 @default.
- W2102661292 hasConcept C54355233 @default.
- W2102661292 hasConcept C71924100 @default.
- W2102661292 hasConcept C86803240 @default.
- W2102661292 hasConcept C95444343 @default.
- W2102661292 hasConceptScore W2102661292C104392178 @default.
- W2102661292 hasConceptScore W2102661292C121608353 @default.
- W2102661292 hasConceptScore W2102661292C142724271 @default.
- W2102661292 hasConceptScore W2102661292C156887251 @default.
- W2102661292 hasConceptScore W2102661292C176860957 @default.
- W2102661292 hasConceptScore W2102661292C199106506 @default.
- W2102661292 hasConceptScore W2102661292C199343813 @default.
- W2102661292 hasConceptScore W2102661292C2778237340 @default.
- W2102661292 hasConceptScore W2102661292C2780814781 @default.
- W2102661292 hasConceptScore W2102661292C502942594 @default.
- W2102661292 hasConceptScore W2102661292C526805850 @default.
- W2102661292 hasConceptScore W2102661292C54355233 @default.
- W2102661292 hasConceptScore W2102661292C71924100 @default.
- W2102661292 hasConceptScore W2102661292C86803240 @default.
- W2102661292 hasConceptScore W2102661292C95444343 @default.
- W2102661292 hasLocation W21026612921 @default.
- W2102661292 hasLocation W21026612922 @default.
- W2102661292 hasOpenAccess W2102661292 @default.
- W2102661292 hasPrimaryLocation W21026612921 @default.
- W2102661292 hasRelatedWork W2035464821 @default.
- W2102661292 hasRelatedWork W2061374201 @default.
- W2102661292 hasRelatedWork W2064784232 @default.
- W2102661292 hasRelatedWork W2102661292 @default.
- W2102661292 hasRelatedWork W2124003449 @default.
- W2102661292 hasRelatedWork W2134123354 @default.
- W2102661292 hasRelatedWork W2168881876 @default.
- W2102661292 hasRelatedWork W2219172500 @default.
- W2102661292 hasRelatedWork W2355539905 @default.
- W2102661292 hasRelatedWork W2224262919 @default.
- W2102661292 isParatext "false" @default.
- W2102661292 isRetracted "false" @default.
- W2102661292 magId "2102661292" @default.
- W2102661292 workType "article" @default.