FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102672130> ?p ?o ?g. }

• W2102672130 endingPage "1470" @default.
• W2102672130 startingPage "1461" @default.
• W2102672130 abstract "Gammaherpesviruses infect at least 90 % of the world's population. Infection control is difficult, in part because some fundamental features of host colonization remain unknown, for example whether normal latency establishment requires viral lytic functions. Since human gammaherpesviruses have narrow species tropisms, answering such questions requires animal models. Murid herpesvirus-4 (MuHV-4) provides one of the most tractable. MuHV-4 genomes delivered to the lung or peritoneum persist without lytic replication. However, they fail to disseminate systemically, suggesting that the outcome is inoculation route-dependent. After upper respiratory tract inoculation, MuHV-4 infects mice without involving the lungs or peritoneum. We examined whether host entry by this less invasive route requires the viral thymidine kinase (TK), a gene classically essential for lytic replication in terminally differentiated cells. MuHV-4 TK knockouts delivered to the lung or peritoneum were attenuated but still reached lymphoid tissue. In contrast, TK knockouts delivered to the upper respiratory tract largely failed to establish a detectable infection. Therefore TK, and by implication lytic replication, is required for MuHV-4 to establish a significant infection by a non-invasive route." @default.
• W2102672130 created "2016-06-24" @default.
• W2102672130 creator A5005237652 @default.
• W2102672130 creator A5023514783 @default.
• W2102672130 creator A5060955442 @default.
• W2102672130 creator A5065325263 @default.
• W2102672130 creator A5027140436 @default.
• W2102672130 date "2009-06-01" @default.
• W2102672130 modified "2023-09-24" @default.
• W2102672130 title "Murid herpesvirus-4 lacking thymidine kinase reveals route-dependent requirements for host colonization" @default.
• W2102672130 cites W1582232587 @default.
• W2102672130 cites W1977891415 @default.
• W2102672130 cites W1980682109 @default.
• W2102672130 cites W1985285050 @default.
• W2102672130 cites W1990437529 @default.
• W2102672130 cites W1994433593 @default.
• W2102672130 cites W2000421708 @default.
• W2102672130 cites W2000869574 @default.
• W2102672130 cites W2006182367 @default.
• W2102672130 cites W2012161992 @default.
• W2102672130 cites W2033313049 @default.
• W2102672130 cites W2036712677 @default.
• W2102672130 cites W2036925007 @default.
• W2102672130 cites W2043238718 @default.
• W2102672130 cites W2046652868 @default.
• W2102672130 cites W2052574932 @default.
• W2102672130 cites W2064908178 @default.
• W2102672130 cites W2064976303 @default.
• W2102672130 cites W2079053367 @default.
• W2102672130 cites W2080646201 @default.
• W2102672130 cites W2090411922 @default.
• W2102672130 cites W2106006522 @default.
• W2102672130 cites W2107380406 @default.
• W2102672130 cites W2118460387 @default.
• W2102672130 cites W2118594571 @default.
• W2102672130 cites W2148146275 @default.
• W2102672130 cites W2154933177 @default.
• W2102672130 cites W2160576221 @default.
• W2102672130 cites W2162157751 @default.
• W2102672130 cites W2167312739 @default.
• W2102672130 cites W2170879194 @default.
• W2102672130 doi "https://doi.org/10.1099/vir.0.010603-0" @default.
• W2102672130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2885060" @default.
• W2102672130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19264614" @default.
• W2102672130 hasPublicationYear "2009" @default.
• W2102672130 type Work @default.
• W2102672130 sameAs 2102672130 @default.
• W2102672130 citedByCount "19" @default.
• W2102672130 countsByYear W21026721302012 @default.
• W2102672130 countsByYear W21026721302014 @default.
• W2102672130 countsByYear W21026721302015 @default.
• W2102672130 countsByYear W21026721302016 @default.
• W2102672130 countsByYear W21026721302017 @default.
• W2102672130 countsByYear W21026721302018 @default.
• W2102672130 countsByYear W21026721302020 @default.
• W2102672130 countsByYear W21026721302023 @default.
• W2102672130 crossrefType "journal-article" @default.
• W2102672130 hasAuthorship W2102672130A5005237652 @default.
• W2102672130 hasAuthorship W2102672130A5023514783 @default.
• W2102672130 hasAuthorship W2102672130A5027140436 @default.
• W2102672130 hasAuthorship W2102672130A5060955442 @default.
• W2102672130 hasAuthorship W2102672130A5065325263 @default.
• W2102672130 hasBestOaLocation W21026721301 @default.
• W2102672130 hasConcept C104317684 @default.
• W2102672130 hasConcept C105702510 @default.
• W2102672130 hasConcept C140704245 @default.
• W2102672130 hasConcept C144024400 @default.
• W2102672130 hasConcept C149923435 @default.
• W2102672130 hasConcept C159047783 @default.
• W2102672130 hasConcept C182615771 @default.
• W2102672130 hasConcept C203014093 @default.
• W2102672130 hasConcept C2522874641 @default.
• W2102672130 hasConcept C2776001837 @default.
• W2102672130 hasConcept C2776147627 @default.
• W2102672130 hasConcept C2779644171 @default.
• W2102672130 hasConcept C2781196997 @default.
• W2102672130 hasConcept C2908647359 @default.
• W2102672130 hasConcept C534529494 @default.
• W2102672130 hasConcept C54355233 @default.
• W2102672130 hasConcept C77957584 @default.
• W2102672130 hasConcept C86803240 @default.
• W2102672130 hasConceptScore W2102672130C104317684 @default.
• W2102672130 hasConceptScore W2102672130C105702510 @default.
• W2102672130 hasConceptScore W2102672130C140704245 @default.
• W2102672130 hasConceptScore W2102672130C144024400 @default.
• W2102672130 hasConceptScore W2102672130C149923435 @default.
• W2102672130 hasConceptScore W2102672130C159047783 @default.
• W2102672130 hasConceptScore W2102672130C182615771 @default.
• W2102672130 hasConceptScore W2102672130C203014093 @default.
• W2102672130 hasConceptScore W2102672130C2522874641 @default.
• W2102672130 hasConceptScore W2102672130C2776001837 @default.
• W2102672130 hasConceptScore W2102672130C2776147627 @default.
• W2102672130 hasConceptScore W2102672130C2779644171 @default.
• W2102672130 hasConceptScore W2102672130C2781196997 @default.
• W2102672130 hasConceptScore W2102672130C2908647359 @default.
• W2102672130 hasConceptScore W2102672130C534529494 @default.
• W2102672130 hasConceptScore W2102672130C54355233 @default.
• W2102672130 hasConceptScore W2102672130C77957584 @default.

• next