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- W2102675610 abstract "The objective of this study was to elucidate the relationship between the triggering receptor expressed on myeloid cells 2 (TREM2) risk variant, neuropathological lesions, alterations in gene and protein expression, and the severity of neuroinflammation.The genetic association study of the R47 H TREM2 variant with Alzheimer's disease (AD), neuropathology, and changes in TREM2 and TYRO protein tyrosine kinase-binding protein (TYROBP) gene and protein expression, and neuroinflammatory markers.The TREM2 variant is associated with: (i) AD (odds ratio: 4.76; P = .014); (ii) increased density of amyloid plaques and neurofibrillary tangles in multiple brain regions; (iii) increased TREM2 (P = .041) and TYROBP (P = .006) gene expression; (iv) decreased TREM2 protein levels (P = .016); and (v) upregulation of proinflammatory cytokines (regulated on activation, normal T cell expressed and secreted [RANTES] and interferon [IFN] gamma) (P = .003) and nominal downregulation of protective markers (α2-macroglobulin, interleukin 4 or IL-4, and ApoA1) (P = .018).These findings link the TREM2 missense mutation with specific molecular abnormalities and increases in neuropathological lesions in the human brain." @default.
- W2102675610 created "2016-06-24" @default.
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- W2102675610 date "2014-12-09" @default.
- W2102675610 modified "2023-10-18" @default.
- W2102675610 title "The triggering receptor expressed on myeloid cells 2 ( <i>TREM2</i> ) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia" @default.
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- W2102675610 doi "https://doi.org/10.1016/j.jalz.2014.10.013" @default.
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