FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102678982> ?p ?o ?g. }

• W2102678982 endingPage "1410" @default.
• W2102678982 startingPage "1403" @default.
• W2102678982 abstract "ABSTRACT Leishmaniasis represents a serious public health problem worldwide. The first line of treatment is based on glucantime and pentostan, which generate toxic effects in treated patients. We have recently shown that amiodarone, frequently used as an antiarrhythmic, possesses activity against Trypanosoma cruzi through the disruption of mitochondrial Ca 2+ homeostasis and the inhibition of parasite ergosterol biosynthesis, specifically at the level of oxidosqualene cyclase activity (G. Benaim, J. Sanders, Y. Garcia-Marchan, C. Colina, R. Lira, A. Caldera, G. Payares, C. Sanoja, J. Burgos, A. Leon-Rossell, J. Concepcion, A. Schijman, M. Levin, E. Oldfield, and J. Urbina, J. Med. Chem. 49:892-899, 2006). Here we show that at therapeutic concentrations, amiodarone has a profound effect on the viability of Leishmania mexicana promastigotes. Additionally, its effect on the viability of the parasite was greater against intracellular amastigotes than against promastigotes, and it did not affect the host cell. Using fluorimetric and confocal microscopy techniques, we also demonstrated that the mechanism of action of amiodarone was related to the disruption of intracellular Ca 2+ homeostasis through a direct action not only on the mitochondria but also on the acidocalcisomes. On the other hand, analysis of the free sterols in promastigotes incubated with amiodarone showed that this drug also affected the biosynthesis of 5-dehydroepisterol, which results in squalene accumulation, thus suggesting that amiodarone inhibits the squalene epoxidase activity of the parasite. Taken together, the results obtained in the present work point to a more general effect of amiodarone in trypanosomatids, opening potential therapeutic possibilities for this infectious disease." @default.
• W2102678982 created "2016-06-24" @default.
• W2102678982 creator A5000876931 @default.
• W2102678982 creator A5001484183 @default.
• W2102678982 creator A5032521884 @default.
• W2102678982 creator A5050423583 @default.
• W2102678982 creator A5051575643 @default.
• W2102678982 creator A5080180627 @default.
• W2102678982 creator A5091224802 @default.
• W2102678982 date "2009-04-01" @default.
• W2102678982 modified "2023-09-27" @default.
• W2102678982 title "Amiodarone Destabilizes Intracellular Ca ²⁺ Homeostasis and Biosynthesis of Sterols in <i>Leishmania mexicana</i>" @default.
• W2102678982 cites W1544998262 @default.
• W2102678982 cites W1957435804 @default.
• W2102678982 cites W1967763539 @default.
• W2102678982 cites W1989968655 @default.
• W2102678982 cites W2021217831 @default.
• W2102678982 cites W2021381859 @default.
• W2102678982 cites W2023674706 @default.
• W2102678982 cites W2071378425 @default.
• W2102678982 cites W2074948368 @default.
• W2102678982 cites W2105523385 @default.
• W2102678982 cites W2109652815 @default.
• W2102678982 cites W2110996726 @default.
• W2102678982 cites W2125566701 @default.
• W2102678982 cites W2133548194 @default.
• W2102678982 cites W2136662212 @default.
• W2102678982 cites W2141260882 @default.
• W2102678982 cites W2141360780 @default.
• W2102678982 cites W2147705199 @default.
• W2102678982 cites W2148589496 @default.
• W2102678982 cites W2171260784 @default.
• W2102678982 cites W2179802582 @default.
• W2102678982 cites W2328789677 @default.
• W2102678982 cites W2342379915 @default.
• W2102678982 cites W2404924867 @default.
• W2102678982 cites W2406204089 @default.
• W2102678982 cites W4248396965 @default.
• W2102678982 cites W9253728 @default.
• W2102678982 doi "https://doi.org/10.1128/aac.01215-08" @default.
• W2102678982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2663059" @default.
• W2102678982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19164149" @default.
• W2102678982 hasPublicationYear "2009" @default.
• W2102678982 type Work @default.
• W2102678982 sameAs 2102678982 @default.
• W2102678982 citedByCount "66" @default.
• W2102678982 countsByYear W21026789822012 @default.
• W2102678982 countsByYear W21026789822013 @default.
• W2102678982 countsByYear W21026789822014 @default.
• W2102678982 countsByYear W21026789822015 @default.
• W2102678982 countsByYear W21026789822016 @default.
• W2102678982 countsByYear W21026789822017 @default.
• W2102678982 countsByYear W21026789822018 @default.
• W2102678982 countsByYear W21026789822019 @default.
• W2102678982 countsByYear W21026789822020 @default.
• W2102678982 countsByYear W21026789822021 @default.
• W2102678982 countsByYear W21026789822022 @default.
• W2102678982 countsByYear W21026789822023 @default.
• W2102678982 crossrefType "journal-article" @default.
• W2102678982 hasAuthorship W2102678982A5000876931 @default.
• W2102678982 hasAuthorship W2102678982A5001484183 @default.
• W2102678982 hasAuthorship W2102678982A5032521884 @default.
• W2102678982 hasAuthorship W2102678982A5050423583 @default.
• W2102678982 hasAuthorship W2102678982A5051575643 @default.
• W2102678982 hasAuthorship W2102678982A5080180627 @default.
• W2102678982 hasAuthorship W2102678982A5091224802 @default.
• W2102678982 hasBestOaLocation W21026789822 @default.
• W2102678982 hasConcept C126322002 @default.
• W2102678982 hasConcept C136764020 @default.
• W2102678982 hasConcept C2777625466 @default.
• W2102678982 hasConcept C2778094803 @default.
• W2102678982 hasConcept C2779161974 @default.
• W2102678982 hasConcept C2781092759 @default.
• W2102678982 hasConcept C2781371782 @default.
• W2102678982 hasConcept C28859421 @default.
• W2102678982 hasConcept C41008148 @default.
• W2102678982 hasConcept C55493867 @default.
• W2102678982 hasConcept C71924100 @default.
• W2102678982 hasConcept C71928629 @default.
• W2102678982 hasConcept C79879829 @default.
• W2102678982 hasConcept C86803240 @default.
• W2102678982 hasConcept C98274493 @default.
• W2102678982 hasConcept C98319499 @default.
• W2102678982 hasConceptScore W2102678982C126322002 @default.
• W2102678982 hasConceptScore W2102678982C136764020 @default.
• W2102678982 hasConceptScore W2102678982C2777625466 @default.
• W2102678982 hasConceptScore W2102678982C2778094803 @default.
• W2102678982 hasConceptScore W2102678982C2779161974 @default.
• W2102678982 hasConceptScore W2102678982C2781092759 @default.
• W2102678982 hasConceptScore W2102678982C2781371782 @default.
• W2102678982 hasConceptScore W2102678982C28859421 @default.
• W2102678982 hasConceptScore W2102678982C41008148 @default.
• W2102678982 hasConceptScore W2102678982C55493867 @default.
• W2102678982 hasConceptScore W2102678982C71924100 @default.
• W2102678982 hasConceptScore W2102678982C71928629 @default.
• W2102678982 hasConceptScore W2102678982C79879829 @default.
• W2102678982 hasConceptScore W2102678982C86803240 @default.
• W2102678982 hasConceptScore W2102678982C98274493 @default.

• next