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- W2102684385 abstract "This study investigated the effects of a skin protectant solution (dimethicone 2%) on clinical signs and skin barrier function in canine atopic dermatitis (AD). Eighteen dogs with AD were randomly divided into two groups, one received dimethicone and the other received the vehicle (cyclomethicone) on selected areas (pinnae, groin, and axillae) daily for 4 weeks. Owners and investigators were blinded regarding group allocation. Clinical efficacy was evaluated using a scoring system and skin barrier by measuring the transepidermal water loss. Twelve dogs completed the study (50% drop rate in the vehicle and 20% in the dimethicone). For clinical signs, analysis of variance showed an effect of time (<svg style=vertical-align:-0.1638pt;width:66.875px; id=M1 height=11.375 version=1.1 viewBox=0 0 66.875 11.375 width=66.875 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,11.112)><path id=x1D443 d=M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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l-26 -65h-233z /></g> </svg>; day 0 <svg style=vertical-align:-0.04095pt;width:10.1px; id=M2 height=8.9125004 version=1.1 viewBox=0 0 10.1 8.9125004 width=10.1 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,8.8)><path id=x3E d=M512 230l-437 -233v58l378 199v2l-378 200v58l437 -233v-51z /></g> </svg> day 28) and region (axillae <svg style=vertical-align:-0.04095pt;width:10.1px; id=M3 height=8.9125004 version=1.1 viewBox=0 0 10.1 8.9125004 width=10.1 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,8.8)><use xlink:href=#x3C/></g> </svg> groin <svg style=vertical-align:-0.04095pt;width:10.1px; id=M4 height=8.9125004 version=1.1 viewBox=0 0 10.1 8.9125004 width=10.1 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,8.8)><use xlink:href=#x3C/></g> </svg> pinnae) but no effect of group or group × time interaction. For transepidermal water loss, analysis of variance showed only a main effect of region (axillae <svg style=vertical-align:-0.04095pt;width:10.1px; id=M5 height=8.9125004 version=1.1 viewBox=0 0 10.1 8.9125004 width=10.1 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,8.8)><use xlink:href=#x3E/></g> </svg> pinnae <svg style=vertical-align:-0.04095pt;width:10.1px; id=M6 height=8.9125004 version=1.1 viewBox=0 0 10.1 8.9125004 width=10.1 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg> <g transform=matrix(.017,-0,0,-.017,.062,8.8)><use xlink:href=#x3E/></g> </svg> groin). Pearson found no correlation between transepidermal water loss and clinical scores. In this pilot study dimethicone had no significant effect on clinical signs and transepidermal water loss in canine atopic dermatitis." @default.
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- W2102684385 date "2013-01-01" @default.
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- W2102684385 title "Pilot Study to Evaluate the Effect of Topical Dimethicone on Clinical Signs and Skin Barrier Function in Dogs with Naturally Occurring Atopic Dermatitis" @default.
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