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- W2102726853 abstract "The effects of thiopental on contraction, membrane potential and membrane ionic currents were studied in single canine left ventricular cells. Thiopental 10(-5) and 10(-4) mol/l reduced the cell-shortening from 7.02 +/- 0.64 microns to 5.66 +/- 1.39 and 3.48 +/- 0.64 microns respectively (mean +/- S.D., N = 10, 0.5 Hz). This effect was enhanced in higher (> 1.0 Hz) electrical stimulation frequencies. Also, thiopental decreased the plateau phase and shortened the duration of action potential. On the other hand, voltage clamp experiment revealed that thiopental 10(-6), 10(-5), and 10(-4) mol/l reduced peak Ca2+ current from 520 +/- 48 pA to 387 +/- 60 pA, 261 +/- 84 pA, and 84 +/- 36 pA respectively (mean +/- S.D., N = 8), and showed a use-dependent block of Ca2+ current. However, only a high dose of thiopental (10(-4) mol/l) inhibited the Na+ current. We conclude that the negative inotropic effect of thiopental on the heart is mediated mainly via inhibition of the Ca2+ current." @default.
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- W2102726853 date "1998-02-01" @default.
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- W2102726853 title "Effects of Thiopental on Contractile and Electrophysiological Properties of Single Canine Left Ventricular Cells" @default.
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- W2102726853 doi "https://doi.org/10.1111/j.1600-0773.1998.tb01405.x" @default.
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