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- W2102742338 endingPage "316" @default.
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- W2102742338 abstract "The post-weaning period in pigs is characterized by an immediate but transient drop in feed intake resulting in severe undernutrition and growth check. This in turn affects various aspects of small intestinal architecture and function leading to gut-associated disorders and often diarrhea. Among these, villus atrophy and digestive enzyme activity depression have been documented. More recent investigations clearly demonstrate early signs of local inflammation including immune cell infiltration and increased pro-inflammatory cytokine gene expression, signs of cytoprotection through up-regulation of so-called heat shock proteins, indications of tissue alterations by proteases (stromelysin) and finally epithelial functional disorders in mineral absorption/secretion and perme- ability. This is followed by a regenerative phase, probably stimulated by feed intake resumption, resulting in down-regulation of many intestinal indicators. However, some of them then display new spatio-temporal adult-type adaptive patterns of maturation. A limited number of substances, partic- ularly nitrogenous compounds and complex preparations of animal origin (colostrum, plasma) have proven to be successful, at least partly, in minimizing post-weaning intestinal disturbances. Thus further research in intestinal physiology, in association with microbiology and immunology, is war- ranted to strengthen our understanding of the mechanisms of gut disorders in order to provide a better rational basis for designing suitable alternatives to in-feed antibiotics for pigs." @default.
- W2102742338 created "2016-06-24" @default.
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- W2102742338 date "2004-07-01" @default.
- W2102742338 modified "2023-10-04" @default.
- W2102742338 title "Gut function and dysfunction in young pigs: physiology" @default.
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- W2102742338 doi "https://doi.org/10.1051/animres:2004018" @default.
- W2102742338 hasPublicationYear "2004" @default.
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