FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102747423> ?p ?o ?g. }

• W2102747423 abstract "Abstract Introduction Early administration of antibiotics for sepsis, and of fluid boluses and vasoactive agents for septic shock, is recommended. Evidence for this in children is limited. Methods The Alberta Sepsis Network prospectively enrolled eligible children admitted to the Pediatric Intensive Care Unit (PICU) with sepsis from 04/2012-10/2014. Demographics, severity of illness, and outcomes variables were prospectively entered into the ASN database after deferred consent. Timing of interventions were determined by retrospective chart review using a study manual and case-report-form. We aimed to determine the association of intervention timing and outcome in children with sepsis. Univariate ( t -test and Fisher’s Exact) and multiple linear regression statistics evaluated predictors of outcomes of PICU length of stay (LOS) and ventilation days. Results Seventy-nine children, age median 60 (IQR 22–133) months, 40 (51 %) female, 39 (49 %) with severe underlying co-morbidity, 44 (56 %) with septic shock, and median PRISM-III 10.5 [IQR 6.0-17.0] were enrolled. Most patients presented in an ED: 36 (46 %) at an outlying hospital ED, and 21 (27 %) at the Children’s Hospital ED. Most infections were pneumonia with/without empyema (42, 53 %), meningitis (11, 14 %), or bacteremia (10, 13 %). The time from presentation to acceptable antibiotic administration was a median of 115.0 [IQR 59.0-323.0] minutes; 20 (25 %) of patients received their antibiotics in the first hour from presentation. Independent predictors of PICU LOS were PRISM-III, and severe underlying co-morbidity, but not time to antibiotics. In the septic shock subgroup, the volume of fluid boluses given in the first 2 hours was independently associated with longer PICU LOS (effect size 0.22 days; 95 % CI 0.5, 0.38; per ml/kg). Independent predictors of ventilator days were PRISM-III score and severe underlying co-morbidity. In the septic shock subgroup, volume of fluid boluses in the first 2 hours was independently associated with more ventilator days (effect size 0.09 days; 95 % CI 0.02, 0.15; per ml/kg). Conclusion Higher volume of early fluid boluses in children with sepsis and septic shock was independently associated with longer PICU LOS and ventilator days. More study on the benefits and harms of fluid bolus therapy in children are needed." @default.
• W2102747423 created "2016-06-24" @default.
• W2102747423 creator A5017605047 @default.
• W2102747423 creator A5019534133 @default.
• W2102747423 creator A5024858579 @default.
• W2102747423 creator A5076427984 @default.
• W2102747423 date "2015-12-01" @default.
• W2102747423 modified "2023-09-23" @default.
• W2102747423 title "Timing of antibiotics, volume, and vasoactive infusions in children with sepsis admitted to intensive care" @default.
• W2102747423 cites W106084640 @default.
• W2102747423 cites W1587114759 @default.
• W2102747423 cites W1839294787 @default.
• W2102747423 cites W192011221 @default.
• W2102747423 cites W1993397663 @default.
• W2102747423 cites W1995887867 @default.
• W2102747423 cites W2006558163 @default.
• W2102747423 cites W2006559509 @default.
• W2102747423 cites W2025430639 @default.
• W2102747423 cites W2035705349 @default.
• W2102747423 cites W2043590195 @default.
• W2102747423 cites W2050260673 @default.
• W2102747423 cites W2066025123 @default.
• W2102747423 cites W2068021013 @default.
• W2102747423 cites W2073316020 @default.
• W2102747423 cites W2076590961 @default.
• W2102747423 cites W2077133466 @default.
• W2102747423 cites W2084445380 @default.
• W2102747423 cites W2090078405 @default.
• W2102747423 cites W2095944485 @default.
• W2102747423 cites W2096350581 @default.
• W2102747423 cites W2096883458 @default.
• W2102747423 cites W2098019283 @default.
• W2102747423 cites W2101612991 @default.
• W2102747423 cites W2104415072 @default.
• W2102747423 cites W2108985682 @default.
• W2102747423 cites W2110387026 @default.
• W2102747423 cites W2117870357 @default.
• W2102747423 cites W2123095004 @default.
• W2102747423 cites W2138697408 @default.
• W2102747423 cites W2147840577 @default.
• W2102747423 cites W2154696953 @default.
• W2102747423 cites W2156065328 @default.
• W2102747423 cites W2156828749 @default.
• W2102747423 cites W2158448358 @default.
• W2102747423 cites W2159933802 @default.
• W2102747423 cites W2160691650 @default.
• W2102747423 cites W2165721969 @default.
• W2102747423 cites W2165760729 @default.
• W2102747423 cites W2168000218 @default.
• W2102747423 cites W2327630244 @default.
• W2102747423 cites W2330497066 @default.
• W2102747423 cites W2581605534 @default.
• W2102747423 cites W3023757607 @default.
• W2102747423 cites W579243759 @default.
• W2102747423 doi "https://doi.org/10.1186/s13054-015-1010-x" @default.
• W2102747423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4539944" @default.
• W2102747423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26283545" @default.
• W2102747423 hasPublicationYear "2015" @default.
• W2102747423 type Work @default.
• W2102747423 sameAs 2102747423 @default.
• W2102747423 citedByCount "58" @default.
• W2102747423 countsByYear W21027474232015 @default.
• W2102747423 countsByYear W21027474232016 @default.
• W2102747423 countsByYear W21027474232017 @default.
• W2102747423 countsByYear W21027474232018 @default.
• W2102747423 countsByYear W21027474232019 @default.
• W2102747423 countsByYear W21027474232020 @default.
• W2102747423 countsByYear W21027474232021 @default.
• W2102747423 countsByYear W21027474232022 @default.
• W2102747423 countsByYear W21027474232023 @default.
• W2102747423 crossrefType "journal-article" @default.
• W2102747423 hasAuthorship W2102747423A5017605047 @default.
• W2102747423 hasAuthorship W2102747423A5019534133 @default.
• W2102747423 hasAuthorship W2102747423A5024858579 @default.
• W2102747423 hasAuthorship W2102747423A5076427984 @default.
• W2102747423 hasBestOaLocation W21027474231 @default.
• W2102747423 hasConcept C126322002 @default.
• W2102747423 hasConcept C144301174 @default.
• W2102747423 hasConcept C177713679 @default.
• W2102747423 hasConcept C187212893 @default.
• W2102747423 hasConcept C194828623 @default.
• W2102747423 hasConcept C2776376669 @default.
• W2102747423 hasConcept C2777628635 @default.
• W2102747423 hasConcept C2777914695 @default.
• W2102747423 hasConcept C2778384902 @default.
• W2102747423 hasConcept C2778939556 @default.
• W2102747423 hasConcept C2779443120 @default.
• W2102747423 hasConcept C38180746 @default.
• W2102747423 hasConcept C501593827 @default.
• W2102747423 hasConcept C71924100 @default.
• W2102747423 hasConcept C86803240 @default.
• W2102747423 hasConcept C89423630 @default.
• W2102747423 hasConceptScore W2102747423C126322002 @default.
• W2102747423 hasConceptScore W2102747423C144301174 @default.
• W2102747423 hasConceptScore W2102747423C177713679 @default.
• W2102747423 hasConceptScore W2102747423C187212893 @default.
• W2102747423 hasConceptScore W2102747423C194828623 @default.
• W2102747423 hasConceptScore W2102747423C2776376669 @default.
• W2102747423 hasConceptScore W2102747423C2777628635 @default.
• W2102747423 hasConceptScore W2102747423C2777914695 @default.

• next