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• W2102752783 abstract "Prion diseases are a group of neurodegenerative conditions of humans and animals that include sporadic, inherited, and transmitted forms. They are best characterized by their distinctive pathogenic mechanism, which is shared by all three forms. The central event in the pathogenesis of these diseases is thought to be a change in protein conformation that results in the conversion of a normal protein, identified as cellular prion protein (PrPC), into an isoform that is partially resistant to proteases (PrPres) (1). The molecular events leading to this conformational change, however, remain largely unknown." @default.
• W2102752783 created "2016-06-24" @default.
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• W2102752783 date "1997-01-01" @default.
• W2102752783 modified "2023-10-17" @default.
• W2102752783 title "Prion Diseases and Dementia" @default.
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• W2102752783 doi "https://doi.org/10.1007/978-1-59259-471-9_18" @default.
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