FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102758774> ?p ?o ?g. }

• W2102758774 endingPage "111" @default.
• W2102758774 startingPage "108" @default.
• W2102758774 abstract "Schnitzler syndrome is a rare disease characterised by chronic urticaria and arthralgia. The recent evidence that the IL-1 receptor antagonist IL-1Ra could induce rapid and complete remission of Schnitzler symptoms has pointed to IL-1 as a major pathological factor in this disease. To examine the possibility that Schnitzler syndrome may be considered to be an autoinflammatory disease, in this study we measured the serum levels of IL-18, another cytokine of the IL-1 family that is cleaved by caspase-1, in two recently diagnosed Schnitzler patients before and after treatment with IL-1Ra. In parallel, mRNA expression of IL-1 family cytokines and caspase-1 were assessed in isolated blood monocytes. Treatment with IL-1Ra significantly inhibited IL-1beta gene expression, indicating that IL-1beta activity in Schnitzler syndrome is central to IL-1beta gene upregulation in a type of auto-amplification loop. While no IL-1beta was detected in serum, free circulating IL-18 was increased in patients with Schnitzler syndrome, despite low IL-18 gene expression in monocytes. This suggests constitutive activation of the IL-1beta/IL-18-producing inflammasome, and supports the hypothesis that Schnitzler's syndrome is a new autoinflammatory disease." @default.
• W2102758774 created "2016-06-24" @default.
• W2102758774 creator A5021256359 @default.
• W2102758774 creator A5024513740 @default.
• W2102758774 creator A5057246307 @default.
• W2102758774 creator A5075633014 @default.
• W2102758774 date "2009-09-01" @default.
• W2102758774 modified "2023-10-12" @default.
• W2102758774 title "Free circulating interleukin-18 is increased in Schnitzler syndrome: a new autoinflammatory disease?" @default.
• W2102758774 cites W1977135749 @default.
• W2102758774 cites W1997720968 @default.
• W2102758774 cites W2032147410 @default.
• W2102758774 cites W2062542142 @default.
• W2102758774 cites W2071935495 @default.
• W2102758774 cites W2086008977 @default.
• W2102758774 cites W2096736571 @default.
• W2102758774 cites W2114769428 @default.
• W2102758774 cites W2135745523 @default.
• W2102758774 cites W2150551517 @default.
• W2102758774 cites W2157675757 @default.
• W2102758774 cites W2171831396 @default.
• W2102758774 doi "https://doi.org/10.1684/ecn.2009.0164" @default.
• W2102758774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19825519" @default.
• W2102758774 hasPublicationYear "2009" @default.
• W2102758774 type Work @default.
• W2102758774 sameAs 2102758774 @default.
• W2102758774 citedByCount "36" @default.
• W2102758774 countsByYear W21027587742012 @default.
• W2102758774 countsByYear W21027587742013 @default.
• W2102758774 countsByYear W21027587742014 @default.
• W2102758774 countsByYear W21027587742015 @default.
• W2102758774 countsByYear W21027587742017 @default.
• W2102758774 countsByYear W21027587742018 @default.
• W2102758774 countsByYear W21027587742019 @default.
• W2102758774 countsByYear W21027587742020 @default.
• W2102758774 countsByYear W21027587742022 @default.
• W2102758774 countsByYear W21027587742023 @default.
• W2102758774 crossrefType "journal-article" @default.
• W2102758774 hasAuthorship W2102758774A5021256359 @default.
• W2102758774 hasAuthorship W2102758774A5024513740 @default.
• W2102758774 hasAuthorship W2102758774A5057246307 @default.
• W2102758774 hasAuthorship W2102758774A5075633014 @default.
• W2102758774 hasConcept C104317684 @default.
• W2102758774 hasConcept C126322002 @default.
• W2102758774 hasConcept C127561419 @default.
• W2102758774 hasConcept C139174496 @default.
• W2102758774 hasConcept C139964883 @default.
• W2102758774 hasConcept C142724271 @default.
• W2102758774 hasConcept C149892131 @default.
• W2102758774 hasConcept C162157009 @default.
• W2102758774 hasConcept C170493617 @default.
• W2102758774 hasConcept C203014093 @default.
• W2102758774 hasConcept C207886595 @default.
• W2102758774 hasConcept C2776885963 @default.
• W2102758774 hasConcept C2776914184 @default.
• W2102758774 hasConcept C2777209026 @default.
• W2102758774 hasConcept C2778122271 @default.
• W2102758774 hasConcept C2778690821 @default.
• W2102758774 hasConcept C2779134260 @default.
• W2102758774 hasConcept C2781228260 @default.
• W2102758774 hasConcept C54355233 @default.
• W2102758774 hasConcept C71924100 @default.
• W2102758774 hasConcept C74172505 @default.
• W2102758774 hasConcept C86803240 @default.
• W2102758774 hasConceptScore W2102758774C104317684 @default.
• W2102758774 hasConceptScore W2102758774C126322002 @default.
• W2102758774 hasConceptScore W2102758774C127561419 @default.
• W2102758774 hasConceptScore W2102758774C139174496 @default.
• W2102758774 hasConceptScore W2102758774C139964883 @default.
• W2102758774 hasConceptScore W2102758774C142724271 @default.
• W2102758774 hasConceptScore W2102758774C149892131 @default.
• W2102758774 hasConceptScore W2102758774C162157009 @default.
• W2102758774 hasConceptScore W2102758774C170493617 @default.
• W2102758774 hasConceptScore W2102758774C203014093 @default.
• W2102758774 hasConceptScore W2102758774C207886595 @default.
• W2102758774 hasConceptScore W2102758774C2776885963 @default.
• W2102758774 hasConceptScore W2102758774C2776914184 @default.
• W2102758774 hasConceptScore W2102758774C2777209026 @default.
• W2102758774 hasConceptScore W2102758774C2778122271 @default.
• W2102758774 hasConceptScore W2102758774C2778690821 @default.
• W2102758774 hasConceptScore W2102758774C2779134260 @default.
• W2102758774 hasConceptScore W2102758774C2781228260 @default.
• W2102758774 hasConceptScore W2102758774C54355233 @default.
• W2102758774 hasConceptScore W2102758774C71924100 @default.
• W2102758774 hasConceptScore W2102758774C74172505 @default.
• W2102758774 hasConceptScore W2102758774C86803240 @default.
• W2102758774 hasIssue "3" @default.
• W2102758774 hasLocation W21027587741 @default.
• W2102758774 hasLocation W21027587742 @default.
• W2102758774 hasOpenAccess W2102758774 @default.
• W2102758774 hasPrimaryLocation W21027587741 @default.
• W2102758774 hasRelatedWork W1998514739 @default.
• W2102758774 hasRelatedWork W2039834735 @default.
• W2102758774 hasRelatedWork W2044459369 @default.
• W2102758774 hasRelatedWork W2052571878 @default.
• W2102758774 hasRelatedWork W2102758774 @default.
• W2102758774 hasRelatedWork W2115867185 @default.
• W2102758774 hasRelatedWork W2143584590 @default.

• next