Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102770635> ?p ?o ?g. }
- W2102770635 endingPage "1195" @default.
- W2102770635 startingPage "1195" @default.
- W2102770635 abstract "The administration of nicotine transiently improves many neurobiological and cognitive functions in schizophrenia and schizoaffective disorder. It is not yet clear which nicotinic acetylcholine receptor (nAChR) subtype or subtypes are responsible for these seemingly pervasive nicotinic effects in schizophrenia and schizoaffective disorder.Because α4β2 is a key nAChR subtype for nicotinic actions, we investigated the effect of varenicline tartrate, a relatively specific α4β2 partial agonist and antagonist, on key biomarkers that are associated with schizophrenia and are previously shown to be responsive to nicotinic challenge in humans.A double-blind, parallel, randomized, placebo-controlled trial of patients with schizophrenia or schizoaffective disorder to examine the effects of varenicline on biomarkers at 2 weeks (short-term treatment) and 8 weeks (long-term treatment), using a slow titration and moderate dosing strategy for retaining α4β2-specific effects while minimizing adverse effects.Outpatient clinics.A total of 69 smoking and nonsmoking patients; 64 patients completed week 2, and 59 patients completed week 8. Intervention Varenicline.Prepulse inhibition, sensory gating, antisaccade, spatial working memory, eye tracking, processing speed, and sustained attention.A moderate dose of varenicline (1) significantly reduced the P50 sensory gating deficit in nonsmokers after long-term treatment (P = .006), (2) reduced startle reactivity (P = .02) regardless of baseline smoking status, and (3) improved executive function by reducing the antisaccadic error rate (P = .03) regardless of smoking status. A moderate dose of varenicline had no significant effect on spatial working memory, predictive and maintenance pursuit measures, processing speed, or sustained attention by Conners' Continuous Performance Test. Clinically, there was no evidence of exacerbation of psychiatric symptoms, psychosis, depression, or suicidality using a gradual titration (1-mg daily dose).Moderate-dose treatment with varenicline has a unique treatment profile on core schizophrenia-related biomarkers. Further development is warranted for specific nAChR compounds and dosing and duration strategies to target subgroups of schizophrenic patients with specific biological deficits." @default.
- W2102770635 created "2016-06-24" @default.
- W2102770635 creator A5002705173 @default.
- W2102770635 creator A5005835928 @default.
- W2102770635 creator A5035495097 @default.
- W2102770635 creator A5045314404 @default.
- W2102770635 creator A5049776657 @default.
- W2102770635 creator A5050105690 @default.
- W2102770635 creator A5070223359 @default.
- W2102770635 creator A5074412924 @default.
- W2102770635 creator A5076260458 @default.
- W2102770635 creator A5078186947 @default.
- W2102770635 creator A5085527407 @default.
- W2102770635 creator A5091344622 @default.
- W2102770635 date "2011-12-01" @default.
- W2102770635 modified "2023-09-22" @default.
- W2102770635 title "Effects of Moderate-Dose Treatment With Varenicline on Neurobiological and Cognitive Biomarkers in Smokers and Nonsmokers With Schizophrenia or Schizoaffective Disorder" @default.
- W2102770635 cites W1532317254 @default.
- W2102770635 cites W1939947624 @default.
- W2102770635 cites W1965198880 @default.
- W2102770635 cites W1966835820 @default.
- W2102770635 cites W1974820883 @default.
- W2102770635 cites W1980359335 @default.
- W2102770635 cites W1982619690 @default.
- W2102770635 cites W1983805722 @default.
- W2102770635 cites W1984425026 @default.
- W2102770635 cites W1985332823 @default.
- W2102770635 cites W1986462906 @default.
- W2102770635 cites W1989893823 @default.
- W2102770635 cites W1990031045 @default.
- W2102770635 cites W1990736520 @default.
- W2102770635 cites W1991697613 @default.
- W2102770635 cites W1993112595 @default.
- W2102770635 cites W1995343350 @default.
- W2102770635 cites W1996605747 @default.
- W2102770635 cites W1998455665 @default.
- W2102770635 cites W2003812062 @default.
- W2102770635 cites W2004618736 @default.
- W2102770635 cites W2004661453 @default.
- W2102770635 cites W2005000985 @default.
- W2102770635 cites W2005394806 @default.
- W2102770635 cites W2005756201 @default.
- W2102770635 cites W2012172073 @default.
- W2102770635 cites W2012786085 @default.
- W2102770635 cites W2015080802 @default.
- W2102770635 cites W2015145583 @default.
- W2102770635 cites W2015676687 @default.
- W2102770635 cites W2015775138 @default.
- W2102770635 cites W2018806863 @default.
- W2102770635 cites W2019990977 @default.
- W2102770635 cites W2023076733 @default.
- W2102770635 cites W2027176128 @default.
- W2102770635 cites W2027621491 @default.
- W2102770635 cites W2027977900 @default.
- W2102770635 cites W2028154685 @default.
- W2102770635 cites W2030085004 @default.
- W2102770635 cites W2030494905 @default.
- W2102770635 cites W2033626300 @default.
- W2102770635 cites W2033734081 @default.
- W2102770635 cites W2035146011 @default.
- W2102770635 cites W2036135297 @default.
- W2102770635 cites W2037807133 @default.
- W2102770635 cites W2043690241 @default.
- W2102770635 cites W2044831514 @default.
- W2102770635 cites W2046768361 @default.
- W2102770635 cites W2049324875 @default.
- W2102770635 cites W2052096985 @default.
- W2102770635 cites W2054023551 @default.
- W2102770635 cites W2055445378 @default.
- W2102770635 cites W2059495695 @default.
- W2102770635 cites W2060474957 @default.
- W2102770635 cites W2068571874 @default.
- W2102770635 cites W2070192651 @default.
- W2102770635 cites W2072150922 @default.
- W2102770635 cites W2072214759 @default.
- W2102770635 cites W2072300339 @default.
- W2102770635 cites W2074017648 @default.
- W2102770635 cites W2076167345 @default.
- W2102770635 cites W2082398071 @default.
- W2102770635 cites W2083876168 @default.
- W2102770635 cites W2084399151 @default.
- W2102770635 cites W2085383806 @default.
- W2102770635 cites W2090019512 @default.
- W2102770635 cites W2093053385 @default.
- W2102770635 cites W2101520329 @default.
- W2102770635 cites W2102366253 @default.
- W2102770635 cites W2105454368 @default.
- W2102770635 cites W2112589080 @default.
- W2102770635 cites W2113308458 @default.
- W2102770635 cites W2115872169 @default.
- W2102770635 cites W2119850780 @default.
- W2102770635 cites W2120431726 @default.
- W2102770635 cites W2121533083 @default.
- W2102770635 cites W2121948831 @default.
- W2102770635 cites W2124533302 @default.
- W2102770635 cites W2131257638 @default.
- W2102770635 cites W2138627575 @default.
- W2102770635 cites W2139385647 @default.