FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102772706> ?p ?o ?g. }

• W2102772706 endingPage "G258" @default.
• W2102772706 startingPage "G251" @default.
• W2102772706 abstract "Human gallbladders with cholesterol stones (ChS) exhibit an impaired muscle contraction and relaxation and a lower CCK receptor-binding capacity compared with those with pigment stones (PS). This study was designed to determine whether there is an abnormal receptor-G protein coupling in human gallbladders with ChS using (35)S-labeled guanosine 5'-O-(3-thiotriphosphate) ([(35)S]GTPgammaS) binding, (125)I-labeled CCK-8 autoradiography, immunoblotting, and G protein quantitation. CCK and vasoactive intestinal peptide caused significant increases in [(35)S]GTPgammaS binding to Galpha(i-3) and G(s)alpha, respectively. The binding was lower in ChS than in PS (P < 0.01). The reduced [(35)S]GTPgammaS binding in ChS was normalized after the muscles were treated with cholesterol-free liposomes (P < 0.01). Autoradiography and immunoblots showed a decreased optical density (OD) for CCK receptors, an even lower OD value for receptor-G protein coupling, and a higher OD for uncoupled receptors or Galpha(i-3) protein in ChS compared with PS (P < 0.001). G protein quantitation also showed that there were no significant differences in the Galpha(i-3) and G(s)alpha content in ChS and PS. We conclude that, in addition to an impaired CCK receptor-binding capacity, there is a defect in receptor-G protein coupling in muscle cells from gallbladder with ChS. These changes may be normalized after removal of excess cholesterol from the plasma membrane." @default.
• W2102772706 created "2016-06-24" @default.
• W2102772706 creator A5000743679 @default.
• W2102772706 creator A5027050509 @default.
• W2102772706 creator A5043448540 @default.
• W2102772706 creator A5068267706 @default.
• W2102772706 creator A5068290128 @default.
• W2102772706 date "2000-02-01" @default.
• W2102772706 modified "2023-09-24" @default.
• W2102772706 title "Defect of receptor-G protein coupling in human gallbladder with cholesterol stones" @default.
• W2102772706 cites W126516170 @default.
• W2102772706 cites W1520161056 @default.
• W2102772706 cites W1565645558 @default.
• W2102772706 cites W1566714709 @default.
• W2102772706 cites W1607371545 @default.
• W2102772706 cites W1645539664 @default.
• W2102772706 cites W1965760487 @default.
• W2102772706 cites W1978053328 @default.
• W2102772706 cites W1983087241 @default.
• W2102772706 cites W1999101834 @default.
• W2102772706 cites W2013613294 @default.
• W2102772706 cites W2015559599 @default.
• W2102772706 cites W2021976124 @default.
• W2102772706 cites W2023286308 @default.
• W2102772706 cites W2044788894 @default.
• W2102772706 cites W2054728789 @default.
• W2102772706 cites W2065031942 @default.
• W2102772706 cites W2083463676 @default.
• W2102772706 cites W2083802495 @default.
• W2102772706 cites W2107552651 @default.
• W2102772706 cites W2112795151 @default.
• W2102772706 cites W2125060118 @default.
• W2102772706 cites W2137776801 @default.
• W2102772706 cites W2154788323 @default.
• W2102772706 cites W2182793460 @default.
• W2102772706 cites W2245119152 @default.
• W2102772706 cites W2280592644 @default.
• W2102772706 cites W2284820033 @default.
• W2102772706 cites W2286785377 @default.
• W2102772706 cites W2319646432 @default.
• W2102772706 cites W2322069423 @default.
• W2102772706 cites W2469130059 @default.
• W2102772706 cites W2472201763 @default.
• W2102772706 cites W26771115 @default.
• W2102772706 cites W348288687 @default.
• W2102772706 cites W4238324979 @default.
• W2102772706 doi "https://doi.org/10.1152/ajpgi.2000.278.2.g251" @default.
• W2102772706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10666049" @default.
• W2102772706 hasPublicationYear "2000" @default.
• W2102772706 type Work @default.
• W2102772706 sameAs 2102772706 @default.
• W2102772706 citedByCount "38" @default.
• W2102772706 countsByYear W21027727062012 @default.
• W2102772706 countsByYear W21027727062013 @default.
• W2102772706 countsByYear W21027727062014 @default.
• W2102772706 countsByYear W21027727062015 @default.
• W2102772706 countsByYear W21027727062016 @default.
• W2102772706 countsByYear W21027727062017 @default.
• W2102772706 countsByYear W21027727062019 @default.
• W2102772706 countsByYear W21027727062020 @default.
• W2102772706 countsByYear W21027727062021 @default.
• W2102772706 countsByYear W21027727062022 @default.
• W2102772706 countsByYear W21027727062023 @default.
• W2102772706 crossrefType "journal-article" @default.
• W2102772706 hasAuthorship W2102772706A5000743679 @default.
• W2102772706 hasAuthorship W2102772706A5027050509 @default.
• W2102772706 hasAuthorship W2102772706A5043448540 @default.
• W2102772706 hasAuthorship W2102772706A5068267706 @default.
• W2102772706 hasAuthorship W2102772706A5068290128 @default.
• W2102772706 hasConcept C118716 @default.
• W2102772706 hasConcept C126322002 @default.
• W2102772706 hasConcept C134018914 @default.
• W2102772706 hasConcept C170493617 @default.
• W2102772706 hasConcept C181199279 @default.
• W2102772706 hasConcept C185592680 @default.
• W2102772706 hasConcept C2777995097 @default.
• W2102772706 hasConcept C2778163477 @default.
• W2102772706 hasConcept C55493867 @default.
• W2102772706 hasConcept C71924100 @default.
• W2102772706 hasConcept C80631254 @default.
• W2102772706 hasConcept C86803240 @default.
• W2102772706 hasConceptScore W2102772706C118716 @default.
• W2102772706 hasConceptScore W2102772706C126322002 @default.
• W2102772706 hasConceptScore W2102772706C134018914 @default.
• W2102772706 hasConceptScore W2102772706C170493617 @default.
• W2102772706 hasConceptScore W2102772706C181199279 @default.
• W2102772706 hasConceptScore W2102772706C185592680 @default.
• W2102772706 hasConceptScore W2102772706C2777995097 @default.
• W2102772706 hasConceptScore W2102772706C2778163477 @default.
• W2102772706 hasConceptScore W2102772706C55493867 @default.
• W2102772706 hasConceptScore W2102772706C71924100 @default.
• W2102772706 hasConceptScore W2102772706C80631254 @default.
• W2102772706 hasConceptScore W2102772706C86803240 @default.
• W2102772706 hasIssue "2" @default.
• W2102772706 hasLocation W21027727061 @default.
• W2102772706 hasLocation W21027727062 @default.
• W2102772706 hasOpenAccess W2102772706 @default.
• W2102772706 hasPrimaryLocation W21027727061 @default.

• next