FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102775501> ?p ?o ?g. }

• W2102775501 endingPage "23023" @default.
• W2102775501 startingPage "23011" @default.
• W2102775501 abstract "Glutamyl-tRNA (Glu-tRNAGlu) is the common substrate for both protein translation and heme biosynthesis via the C5 pathway. Under normal conditions, an adequate supply of this aminoacyl-tRNA is available to both pathways. However, under certain circumstances, Glu-tRNAGlu can become scarce, resulting in competition between the two pathways for this aminoacyl-tRNA. In Acidithiobacillus ferrooxidans, glutamyl-tRNA synthetase 1 (GluRS1) is the main enzyme that synthesizes Glu-tRNAGlu. Previous studies have shown that GluRS1 is inactivated in vitro by hydrogen peroxide (H2O2). This raises the question as to whether H2O2 negatively affects in vivo GluRS1 activity in A. ferrooxidans and whether Glu-tRNAGlu distribution between the heme and protein biosynthesis processes may be affected by these conditions. To address this issue, we measured GluRS1 activity. We determined that GluRS1 is inactivated when cells are exposed to H2O2, with a concomitant reduction in intracellular heme level. The effects of H2O2 on the activity of purified glutamyl-tRNA reductase (GluTR), the key enzyme for heme biosynthesis, and on the elongation factor Tu (EF-Tu) were also measured. While exposing purified GluTR, the first enzyme of heme biosynthesis, to H2O2 resulted in its inactivation, the binding of glutamyl-tRNA to EF-Tu was not affected. Taken together, these data suggest that in A. ferrooxidans, the flow of glutamyl-tRNA is diverted from heme biosynthesis towards protein synthesis under oxidative stress conditions." @default.
• W2102775501 created "2016-06-24" @default.
• W2102775501 creator A5024244207 @default.
• W2102775501 creator A5025010731 @default.
• W2102775501 creator A5035075327 @default.
• W2102775501 creator A5068381506 @default.
• W2102775501 date "2014-12-11" @default.
• W2102775501 modified "2023-10-03" @default.
• W2102775501 title "Effect of Hydrogen Peroxide on the Biosynthesis of Heme and Proteins: Potential Implications for the Partitioning of Glu-tRNAGlu between These Pathways" @default.
• W2102775501 cites W1547007984 @default.
• W2102775501 cites W1605002548 @default.
• W2102775501 cites W171117290 @default.
• W2102775501 cites W1762630411 @default.
• W2102775501 cites W1967448903 @default.
• W2102775501 cites W1968395453 @default.
• W2102775501 cites W1986748372 @default.
• W2102775501 cites W1987489694 @default.
• W2102775501 cites W1988027333 @default.
• W2102775501 cites W1989376033 @default.
• W2102775501 cites W1996227484 @default.
• W2102775501 cites W2015936047 @default.
• W2102775501 cites W2016750393 @default.
• W2102775501 cites W2017215072 @default.
• W2102775501 cites W2032451049 @default.
• W2102775501 cites W2051780892 @default.
• W2102775501 cites W2053994975 @default.
• W2102775501 cites W2078752925 @default.
• W2102775501 cites W2081351825 @default.
• W2102775501 cites W2081745487 @default.
• W2102775501 cites W2106687404 @default.
• W2102775501 cites W2113876632 @default.
• W2102775501 cites W2122340589 @default.
• W2102775501 cites W2127264080 @default.
• W2102775501 cites W2127749120 @default.
• W2102775501 cites W2137024316 @default.
• W2102775501 cites W2139653523 @default.
• W2102775501 cites W2140020971 @default.
• W2102775501 cites W2163116972 @default.
• W2102775501 cites W2169564814 @default.
• W2102775501 cites W282816496 @default.
• W2102775501 cites W4237088334 @default.
• W2102775501 cites W4243846682 @default.
• W2102775501 cites W51145013 @default.
• W2102775501 doi "https://doi.org/10.3390/ijms151223011" @default.
• W2102775501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4284751" @default.
• W2102775501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25514408" @default.
• W2102775501 hasPublicationYear "2014" @default.
• W2102775501 type Work @default.
• W2102775501 sameAs 2102775501 @default.
• W2102775501 citedByCount "4" @default.
• W2102775501 countsByYear W21027755012016 @default.
• W2102775501 countsByYear W21027755012018 @default.
• W2102775501 countsByYear W21027755012019 @default.
• W2102775501 crossrefType "journal-article" @default.
• W2102775501 hasAuthorship W2102775501A5024244207 @default.
• W2102775501 hasAuthorship W2102775501A5025010731 @default.
• W2102775501 hasAuthorship W2102775501A5035075327 @default.
• W2102775501 hasAuthorship W2102775501A5068381506 @default.
• W2102775501 hasBestOaLocation W21027755011 @default.
• W2102775501 hasConcept C104317684 @default.
• W2102775501 hasConcept C153957851 @default.
• W2102775501 hasConcept C181199279 @default.
• W2102775501 hasConcept C185592680 @default.
• W2102775501 hasConcept C2776217839 @default.
• W2102775501 hasConcept C2780658535 @default.
• W2102775501 hasConcept C3675279 @default.
• W2102775501 hasConcept C533411734 @default.
• W2102775501 hasConcept C553450214 @default.
• W2102775501 hasConcept C55493867 @default.
• W2102775501 hasConcept C67705224 @default.
• W2102775501 hasConcept C86803240 @default.
• W2102775501 hasConceptScore W2102775501C104317684 @default.
• W2102775501 hasConceptScore W2102775501C153957851 @default.
• W2102775501 hasConceptScore W2102775501C181199279 @default.
• W2102775501 hasConceptScore W2102775501C185592680 @default.
• W2102775501 hasConceptScore W2102775501C2776217839 @default.
• W2102775501 hasConceptScore W2102775501C2780658535 @default.
• W2102775501 hasConceptScore W2102775501C3675279 @default.
• W2102775501 hasConceptScore W2102775501C533411734 @default.
• W2102775501 hasConceptScore W2102775501C553450214 @default.
• W2102775501 hasConceptScore W2102775501C55493867 @default.
• W2102775501 hasConceptScore W2102775501C67705224 @default.
• W2102775501 hasConceptScore W2102775501C86803240 @default.
• W2102775501 hasIssue "12" @default.
• W2102775501 hasLocation W21027755011 @default.
• W2102775501 hasLocation W21027755012 @default.
• W2102775501 hasLocation W21027755013 @default.
• W2102775501 hasLocation W21027755014 @default.
• W2102775501 hasLocation W21027755015 @default.
• W2102775501 hasOpenAccess W2102775501 @default.
• W2102775501 hasPrimaryLocation W21027755011 @default.
• W2102775501 hasRelatedWork W1578843924 @default.
• W2102775501 hasRelatedWork W2004364835 @default.
• W2102775501 hasRelatedWork W2050491613 @default.
• W2102775501 hasRelatedWork W2060302853 @default.
• W2102775501 hasRelatedWork W2093534288 @default.
• W2102775501 hasRelatedWork W2095940932 @default.
• W2102775501 hasRelatedWork W2102775501 @default.

• next