FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102799478> ?p ?o ?g. }

• W2102799478 endingPage "839" @default.
• W2102799478 startingPage "835" @default.
• W2102799478 abstract "Imatinib at a daily dose of 400 mg is the standard treatment for chronic myelogenous leukemia in the chronic phase. However, the feasibility of this dose for small Japanese adults has not been clarified. We prospectively investigated the toxicity and efficacy of this dose in adult Japanese patients. Among the 89 evaluable patients with a median body weight of 62.8 kg, imatinib therapy was held in 40 subjects (45%), due to Grade 3-4 toxicities in 30 patients (75%) and Grade 2 toxicities at the discretion of the attending physician in 10 patients (25%). However, treatment was resumed and the dose was gradually increased until 62 of the 89 patients tolerated a maintenance dose of 400 mg. Older age and lower body weight were significant independent risk factors for discontinuation of imatinib. After a median follow-up period of 31 months, 84 patients were alive without progression. The complete cytogenetic response rate was 60 and 90% at 6 months and 1 year after starting imatinib, respectively. Older patients and those with a lower body weight were less likely to achieve a complete cytogenetic response. These findings suggest that the body weight has a significant influence on the toxicity and efficacy of imatinib in patients with a small body size, although dose reduction in proportion to weight may result in an inadequate response to imatinib." @default.
• W2102799478 created "2016-06-24" @default.
• W2102799478 creator A5004594681 @default.
• W2102799478 creator A5006261532 @default.
• W2102799478 creator A5009975594 @default.
• W2102799478 creator A5013090266 @default.
• W2102799478 creator A5013112899 @default.
• W2102799478 creator A5018814821 @default.
• W2102799478 creator A5035224776 @default.
• W2102799478 creator A5044647383 @default.
• W2102799478 creator A5045270299 @default.
• W2102799478 creator A5053689963 @default.
• W2102799478 creator A5056134258 @default.
• W2102799478 creator A5067804516 @default.
• W2102799478 creator A5074835045 @default.
• W2102799478 creator A5083522292 @default.
• W2102799478 creator A5085709435 @default.
• W2102799478 creator A5087601635 @default.
• W2102799478 creator A5087788162 @default.
• W2102799478 creator A5089743694 @default.
• W2102799478 date "2008-11-01" @default.
• W2102799478 modified "2023-09-22" @default.
• W2102799478 title "Multicenter prospective trial evaluating the tolerability of imatinib for Japanese patients with chronic myelogenous leukemia in the chronic phase: Does body weight matter?" @default.
• W2102799478 cites W1978821257 @default.
• W2102799478 cites W1992781063 @default.
• W2102799478 cites W2006917576 @default.
• W2102799478 cites W2011474502 @default.
• W2102799478 cites W2028959752 @default.
• W2102799478 cites W2055515709 @default.
• W2102799478 cites W2079517811 @default.
• W2102799478 cites W2084452268 @default.
• W2102799478 cites W2089483984 @default.
• W2102799478 cites W2107268345 @default.
• W2102799478 cites W2151486690 @default.
• W2102799478 cites W2587858544 @default.
• W2102799478 cites W2612051898 @default.
• W2102799478 doi "https://doi.org/10.1002/ajh.21274" @default.
• W2102799478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18785644" @default.
• W2102799478 hasPublicationYear "2008" @default.
• W2102799478 type Work @default.
• W2102799478 sameAs 2102799478 @default.
• W2102799478 citedByCount "17" @default.
• W2102799478 countsByYear W21027994782012 @default.
• W2102799478 countsByYear W21027994782015 @default.
• W2102799478 countsByYear W21027994782018 @default.
• W2102799478 countsByYear W21027994782021 @default.
• W2102799478 crossrefType "journal-article" @default.
• W2102799478 hasAuthorship W2102799478A5004594681 @default.
• W2102799478 hasAuthorship W2102799478A5006261532 @default.
• W2102799478 hasAuthorship W2102799478A5009975594 @default.
• W2102799478 hasAuthorship W2102799478A5013090266 @default.
• W2102799478 hasAuthorship W2102799478A5013112899 @default.
• W2102799478 hasAuthorship W2102799478A5018814821 @default.
• W2102799478 hasAuthorship W2102799478A5035224776 @default.
• W2102799478 hasAuthorship W2102799478A5044647383 @default.
• W2102799478 hasAuthorship W2102799478A5045270299 @default.
• W2102799478 hasAuthorship W2102799478A5053689963 @default.
• W2102799478 hasAuthorship W2102799478A5056134258 @default.
• W2102799478 hasAuthorship W2102799478A5067804516 @default.
• W2102799478 hasAuthorship W2102799478A5074835045 @default.
• W2102799478 hasAuthorship W2102799478A5083522292 @default.
• W2102799478 hasAuthorship W2102799478A5085709435 @default.
• W2102799478 hasAuthorship W2102799478A5087601635 @default.
• W2102799478 hasAuthorship W2102799478A5087788162 @default.
• W2102799478 hasAuthorship W2102799478A5089743694 @default.
• W2102799478 hasBestOaLocation W21027994781 @default.
• W2102799478 hasConcept C126322002 @default.
• W2102799478 hasConcept C141071460 @default.
• W2102799478 hasConcept C188816634 @default.
• W2102799478 hasConcept C197934379 @default.
• W2102799478 hasConcept C2776960273 @default.
• W2102799478 hasConcept C2777583451 @default.
• W2102799478 hasConcept C2778375690 @default.
• W2102799478 hasConcept C2778461978 @default.
• W2102799478 hasConcept C2778715236 @default.
• W2102799478 hasConcept C2778729363 @default.
• W2102799478 hasConcept C29730261 @default.
• W2102799478 hasConcept C3019892230 @default.
• W2102799478 hasConcept C71924100 @default.
• W2102799478 hasConcept C90924648 @default.
• W2102799478 hasConceptScore W2102799478C126322002 @default.
• W2102799478 hasConceptScore W2102799478C141071460 @default.
• W2102799478 hasConceptScore W2102799478C188816634 @default.
• W2102799478 hasConceptScore W2102799478C197934379 @default.
• W2102799478 hasConceptScore W2102799478C2776960273 @default.
• W2102799478 hasConceptScore W2102799478C2777583451 @default.
• W2102799478 hasConceptScore W2102799478C2778375690 @default.
• W2102799478 hasConceptScore W2102799478C2778461978 @default.
• W2102799478 hasConceptScore W2102799478C2778715236 @default.
• W2102799478 hasConceptScore W2102799478C2778729363 @default.
• W2102799478 hasConceptScore W2102799478C29730261 @default.
• W2102799478 hasConceptScore W2102799478C3019892230 @default.
• W2102799478 hasConceptScore W2102799478C71924100 @default.
• W2102799478 hasConceptScore W2102799478C90924648 @default.
• W2102799478 hasIssue "11" @default.
• W2102799478 hasLocation W21027994781 @default.
• W2102799478 hasLocation W21027994782 @default.
• W2102799478 hasOpenAccess W2102799478 @default.

• next