FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102814989> ?p ?o ?g. }

• W2102814989 abstract "Background: The need for repetition of liver biopsy, especially in assessing the degree of fibrosis and follow-up of treatment protocols, justifies an intensive search for non-invasive alternatives. We attempted to investigate the clinical usefulness of serum fibrogenesis markers in pediatric chronic liver diseases. Methods: We measured serum levels of TGF-beta1, collagen IV, laminin, MMP-2 and EGF-R, in 50 children with chronic liver disease (HBV, HCV and Bilharziasis) and 30 healthy controls, and determined their relationship to frequently used liver function tests and liver biopsy findings in patients. Results: TGF-beta1, collagen IV, laminin and MMP-2, but not EGF-R, were significantly higher in patients than in controls (P < 0.01). None of these markers correlated with the histological fibrosis stage, whereas laminin correlated with necroinflammatory activity (P < 0.01). TGF-beta1, collagen IV, laminin and MMP-2 had the ability to discriminate patients with significant fibrosis, while only collagen IV and laminin were able to discriminate those with cirrhosis. Among these markers, collagen IV had the best predictive accuracy for significant fibrosis (AUROC 0.94; PPV 91.5%) and cirrhosis (AUROC 0.85; PPV 80%). Conclusions: In conclusion, these markers may be useful in reducing but not replacing the need for liver biopsy in the monitoring of disease progression and treatment effectiveness and might be an inseparable part of assessment of chronic hepatopathies. Gastroenterol Res. 2010;3(6):262-271 doi: https://doi.org/10.4021/gr246w" @default.
• W2102814989 created "2016-06-24" @default.
• W2102814989 creator A5078583886 @default.
• W2102814989 date "2011-01-01" @default.
• W2102814989 modified "2023-10-18" @default.
• W2102814989 title "Clinical Benefits of Biochemical Markers of Fibrosis in Egyptian Children With Chronic Liver Diseases" @default.
• W2102814989 cites W117859416 @default.
• W2102814989 cites W1528276056 @default.
• W2102814989 cites W1548479200 @default.
• W2102814989 cites W163630733 @default.
• W2102814989 cites W164180253 @default.
• W2102814989 cites W1907047013 @default.
• W2102814989 cites W1937013768 @default.
• W2102814989 cites W1944256851 @default.
• W2102814989 cites W1963850184 @default.
• W2102814989 cites W1968806743 @default.
• W2102814989 cites W1980325398 @default.
• W2102814989 cites W1981900811 @default.
• W2102814989 cites W1982229847 @default.
• W2102814989 cites W2004679437 @default.
• W2102814989 cites W2011549038 @default.
• W2102814989 cites W2015381959 @default.
• W2102814989 cites W2018633516 @default.
• W2102814989 cites W2026216011 @default.
• W2102814989 cites W2028718846 @default.
• W2102814989 cites W2039606716 @default.
• W2102814989 cites W2049533426 @default.
• W2102814989 cites W2056259629 @default.
• W2102814989 cites W2062657580 @default.
• W2102814989 cites W2079105341 @default.
• W2102814989 cites W2079887343 @default.
• W2102814989 cites W2080325240 @default.
• W2102814989 cites W2084466277 @default.
• W2102814989 cites W2087290401 @default.
• W2102814989 cites W2088088552 @default.
• W2102814989 cites W2091332120 @default.
• W2102814989 cites W2091386218 @default.
• W2102814989 cites W2093514870 @default.
• W2102814989 cites W2130445180 @default.
• W2102814989 cites W2149072614 @default.
• W2102814989 cites W2149489859 @default.
• W2102814989 cites W2152319801 @default.
• W2102814989 cites W2366456785 @default.
• W2102814989 cites W2390642446 @default.
• W2102814989 cites W2417211017 @default.
• W2102814989 cites W2464174823 @default.
• W2102814989 cites W338906618 @default.
• W2102814989 cites W2068377410 @default.
• W2102814989 doi "https://doi.org/10.4021/gr246w" @default.
• W2102814989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5139854" @default.
• W2102814989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27942306" @default.
• W2102814989 hasPublicationYear "2011" @default.
• W2102814989 type Work @default.
• W2102814989 sameAs 2102814989 @default.
• W2102814989 citedByCount "5" @default.
• W2102814989 countsByYear W21028149892012 @default.
• W2102814989 countsByYear W21028149892015 @default.
• W2102814989 countsByYear W21028149892016 @default.
• W2102814989 countsByYear W21028149892019 @default.
• W2102814989 crossrefType "journal-article" @default.
• W2102814989 hasAuthorship W2102814989A5078583886 @default.
• W2102814989 hasBestOaLocation W21028149891 @default.
• W2102814989 hasConcept C126322002 @default.
• W2102814989 hasConcept C142724271 @default.
• W2102814989 hasConcept C189165786 @default.
• W2102814989 hasConcept C2775934546 @default.
• W2102814989 hasConcept C2777075537 @default.
• W2102814989 hasConcept C2777107211 @default.
• W2102814989 hasConcept C2777214474 @default.
• W2102814989 hasConcept C2777766500 @default.
• W2102814989 hasConcept C2779102576 @default.
• W2102814989 hasConcept C2779814568 @default.
• W2102814989 hasConcept C2780559512 @default.
• W2102814989 hasConcept C2993667909 @default.
• W2102814989 hasConcept C71924100 @default.
• W2102814989 hasConcept C86803240 @default.
• W2102814989 hasConcept C90924648 @default.
• W2102814989 hasConcept C95444343 @default.
• W2102814989 hasConceptScore W2102814989C126322002 @default.
• W2102814989 hasConceptScore W2102814989C142724271 @default.
• W2102814989 hasConceptScore W2102814989C189165786 @default.
• W2102814989 hasConceptScore W2102814989C2775934546 @default.
• W2102814989 hasConceptScore W2102814989C2777075537 @default.
• W2102814989 hasConceptScore W2102814989C2777107211 @default.
• W2102814989 hasConceptScore W2102814989C2777214474 @default.
• W2102814989 hasConceptScore W2102814989C2777766500 @default.
• W2102814989 hasConceptScore W2102814989C2779102576 @default.
• W2102814989 hasConceptScore W2102814989C2779814568 @default.
• W2102814989 hasConceptScore W2102814989C2780559512 @default.
• W2102814989 hasConceptScore W2102814989C2993667909 @default.
• W2102814989 hasConceptScore W2102814989C71924100 @default.
• W2102814989 hasConceptScore W2102814989C86803240 @default.
• W2102814989 hasConceptScore W2102814989C90924648 @default.
• W2102814989 hasConceptScore W2102814989C95444343 @default.
• W2102814989 hasLocation W21028149891 @default.
• W2102814989 hasLocation W21028149892 @default.
• W2102814989 hasLocation W21028149893 @default.
• W2102814989 hasLocation W21028149894 @default.
• W2102814989 hasOpenAccess W2102814989 @default.
• W2102814989 hasPrimaryLocation W21028149891 @default.

• next