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- W2102818251 endingPage "857" @default.
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- W2102818251 abstract "Despite encouraging scientific and therapeutic advances, chronic lymphocytic leukemia (CLL) principally remains an incurable disease. Allogeneic transplantation represents the only curative approach, but is marked by high mortality. Novel and less toxic treatment modalities are needed. Immunotherapeutic approaches have clearly demonstrated potential effectiveness in CLL and other B-cell malignancies. To successfully direct immunity against CLL, highly immunogenic tumor cells or tumor-antigen-loaded antigen-presenting cells are necessary. The CD40–CD40L interaction has been shown to significantly increase antigen presentation in normal and malignant B-cells. Here we discuss biology and potential therapeutic applications of the CD40-system in CLL." @default.
- W2102818251 created "2016-06-24" @default.
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- W2102818251 creator A5059931392 @default.
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- W2102818251 date "2004-06-01" @default.
- W2102818251 modified "2023-09-23" @default.
- W2102818251 title "CD40 activation: potential for specific immunotherapy in B-CLL" @default.
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- W2102818251 doi "https://doi.org/10.1093/annonc/mdh213" @default.
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