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- W2102820745 abstract "Functional imaging provides a valuable adjunct to clinical evaluation for assessing the efficacy of cell-based restorative therapies in Parkinson's disease (PD). In this article, we review the latest advances on the use of positron emission tomography (PET) imaging in evaluating the surgical outcome of embryonic dopamine (DA) cell transplantation in PD patients. These studies suggest long-term cell survival and clinical benefit following striatal transplantation of fetal nigral tissue in PD patients and in models of experimental parkinsonism. Adverse events subsequent to transplantation have also been noted and attributed to a variety of causes. Optimal outcomes of DA cell transplantation therapies are dependent on tissue composition and phenotype of DA neurons in the graft. Given continued progress in DA neuron production from stem cells in recent years, transplantation of neural stem cells may be the next to enter clinical trials in patients. The existing data from studies of embryonic DA transplantation for advanced PD have provided valuable insights for the design of new cell-based therapies for the treatment of this and related neurodegenerative disorders." @default.
- W2102820745 created "2016-06-24" @default.
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- W2102820745 date "2011-08-28" @default.
- W2102820745 modified "2023-10-16" @default.
- W2102820745 title "Dopamine cell transplantation in Parkinson's disease: challenge and perspective" @default.
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- W2102820745 doi "https://doi.org/10.1093/bmb/ldr040" @default.
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