FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102827895> ?p ?o ?g. }

• W2102827895 endingPage "126" @default.
• W2102827895 startingPage "120" @default.
• W2102827895 abstract "The mitotic spindle assembly checkpoint (SAC) ensures faithful chromosome segregation during mitosis by censoring kinetochore–microtubule interactions. It is frequently rendered dysfunctional during carcinogenesis causing chromosome missegregation and genomic instability. There are conflicting reports whether the HPV16 E7 oncoprotein drives chromosomal instability by abolishing the SAC. Here we report that degradation of mitotic cyclins is impaired in cells with HPV16 E7 expression. RNAi-mediated depletion of Mad2 or BubR1 indicated the involvement of the SAC, suggesting that HPV16 E7 expression causes sustained SAC engagement. Mutational analyses revealed that HPV16 E7 sequences that are necessary for retinoblastoma tumor suppressor protein binding as well as sequences previously implicated in binding the nuclear and mitotic apparatus (NuMA) protein and in delocalizing dynein from the mitotic spindle contribute to SAC engagement. Importantly, however, HPV16 E7 does not markedly compromise the SAC response to microtubule poisons." @default.
• W2102827895 created "2016-06-24" @default.
• W2102827895 creator A5001039737 @default.
• W2102827895 creator A5067888149 @default.
• W2102827895 date "2012-10-01" @default.
• W2102827895 modified "2023-10-16" @default.
• W2102827895 title "Human papillomavirus type 16 E7 oncoprotein engages but does not abrogate the mitotic spindle assembly checkpoint" @default.
• W2102827895 cites W1963750681 @default.
• W2102827895 cites W1969236463 @default.
• W2102827895 cites W1973916918 @default.
• W2102827895 cites W1974225684 @default.
• W2102827895 cites W1984328656 @default.
• W2102827895 cites W2000991672 @default.
• W2102827895 cites W2029875848 @default.
• W2102827895 cites W2039426604 @default.
• W2102827895 cites W2040115433 @default.
• W2102827895 cites W2041206676 @default.
• W2102827895 cites W2048938594 @default.
• W2102827895 cites W2053146635 @default.
• W2102827895 cites W2061862766 @default.
• W2102827895 cites W2062117947 @default.
• W2102827895 cites W2067290862 @default.
• W2102827895 cites W2076212147 @default.
• W2102827895 cites W2077155376 @default.
• W2102827895 cites W2081784458 @default.
• W2102827895 cites W2086453272 @default.
• W2102827895 cites W2104458086 @default.
• W2102827895 cites W2110224208 @default.
• W2102827895 cites W2123820544 @default.
• W2102827895 cites W2129153399 @default.
• W2102827895 cites W2130335557 @default.
• W2102827895 cites W2131048186 @default.
• W2102827895 cites W2134734479 @default.
• W2102827895 cites W2147762577 @default.
• W2102827895 cites W2150668123 @default.
• W2102827895 cites W2164613622 @default.
• W2102827895 doi "https://doi.org/10.1016/j.virol.2012.06.006" @default.
• W2102827895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3402702" @default.
• W2102827895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22748180" @default.
• W2102827895 hasPublicationYear "2012" @default.
• W2102827895 type Work @default.
• W2102827895 sameAs 2102827895 @default.
• W2102827895 citedByCount "11" @default.
• W2102827895 countsByYear W21028278952013 @default.
• W2102827895 countsByYear W21028278952014 @default.
• W2102827895 countsByYear W21028278952015 @default.
• W2102827895 countsByYear W21028278952018 @default.
• W2102827895 countsByYear W21028278952019 @default.
• W2102827895 countsByYear W21028278952020 @default.
• W2102827895 countsByYear W21028278952021 @default.
• W2102827895 countsByYear W21028278952023 @default.
• W2102827895 crossrefType "journal-article" @default.
• W2102827895 hasAuthorship W2102827895A5001039737 @default.
• W2102827895 hasAuthorship W2102827895A5067888149 @default.
• W2102827895 hasBestOaLocation W21028278951 @default.
• W2102827895 hasConcept C104317684 @default.
• W2102827895 hasConcept C140752955 @default.
• W2102827895 hasConcept C142669718 @default.
• W2102827895 hasConcept C143425029 @default.
• W2102827895 hasConcept C1491633281 @default.
• W2102827895 hasConcept C175732170 @default.
• W2102827895 hasConcept C178169997 @default.
• W2102827895 hasConcept C192838845 @default.
• W2102827895 hasConcept C20418707 @default.
• W2102827895 hasConcept C2777563682 @default.
• W2102827895 hasConcept C2778354886 @default.
• W2102827895 hasConcept C2779363559 @default.
• W2102827895 hasConcept C2780391303 @default.
• W2102827895 hasConcept C30481170 @default.
• W2102827895 hasConcept C47432576 @default.
• W2102827895 hasConcept C54355233 @default.
• W2102827895 hasConcept C552990157 @default.
• W2102827895 hasConcept C6391034 @default.
• W2102827895 hasConcept C85813293 @default.
• W2102827895 hasConcept C86803240 @default.
• W2102827895 hasConcept C93304396 @default.
• W2102827895 hasConcept C95444343 @default.
• W2102827895 hasConceptScore W2102827895C104317684 @default.
• W2102827895 hasConceptScore W2102827895C140752955 @default.
• W2102827895 hasConceptScore W2102827895C142669718 @default.
• W2102827895 hasConceptScore W2102827895C143425029 @default.
• W2102827895 hasConceptScore W2102827895C1491633281 @default.
• W2102827895 hasConceptScore W2102827895C175732170 @default.
• W2102827895 hasConceptScore W2102827895C178169997 @default.
• W2102827895 hasConceptScore W2102827895C192838845 @default.
• W2102827895 hasConceptScore W2102827895C20418707 @default.
• W2102827895 hasConceptScore W2102827895C2777563682 @default.
• W2102827895 hasConceptScore W2102827895C2778354886 @default.
• W2102827895 hasConceptScore W2102827895C2779363559 @default.
• W2102827895 hasConceptScore W2102827895C2780391303 @default.
• W2102827895 hasConceptScore W2102827895C30481170 @default.
• W2102827895 hasConceptScore W2102827895C47432576 @default.
• W2102827895 hasConceptScore W2102827895C54355233 @default.
• W2102827895 hasConceptScore W2102827895C552990157 @default.
• W2102827895 hasConceptScore W2102827895C6391034 @default.
• W2102827895 hasConceptScore W2102827895C85813293 @default.
• W2102827895 hasConceptScore W2102827895C86803240 @default.
• W2102827895 hasConceptScore W2102827895C93304396 @default.

• next