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• W2102844953 abstract "<h3>Background</h3> Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammation. <h3>Objective</h3> To demonstrate, by a multicentre prospective cohort study, that the risk of metachronous gastric cancer after endoscopic resection (ER) can be predicted by assessment of the epigenetic field defect using methylation levels. <h3>Design</h3> Patients with early gastric cancer, aged 40–80 years, who planned to have, or had undergone, ER, were enrolled at least 6 months after <i>Helicobacter pylori</i> infection discontinued. Methylation levels of three preselected genes (<i>miR-124a-3</i>, <i>EMX1</i> and <i>NKX6-1</i>) were measured by quantitative methylation-specific PCR. Patients were followed up annually by endoscopy, and the primary endpoint was defined as detection of a metachronous gastric cancer. Authentic metachronous gastric cancers were defined as cancers excluding those detected within 1 year after the enrolment. <h3>Results</h3> Among 826 patients enrolled, 782 patients had at least one follow-up, with a median follow-up of 2.97 years. Authentic metachronous gastric cancers developed in 66 patients: 29, 16 and 21 patients at 1–2, 2–3 and ≥3 years after the enrolment, respectively. The highest quartile of the <i>miR-124a-3</i> methylation level had a significant univariate HR (95% CI) (2.17 (1.07 to 4.41); p=0.032) and a multivariate-adjusted HR (2.30 (1.03 to 5.10); p=0.042) of developing authentic metachronous gastric cancers. Similar trends were seen for <i>EMX1</i> and <i>NKX6-1</i>. <h3>Conclusions</h3> Assessment of the degree of an epigenetic field defect is a promising cancer risk marker that takes account of life history." @default.
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• W2102844953 date "2014-06-02" @default.
• W2102844953 modified "2023-10-03" @default.
• W2102844953 title "Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study" @default.
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• W2102844953 doi "https://doi.org/10.1136/gutjnl-2014-307094" @default.
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