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- W2102859097 abstract "Much of cancer genetics research has focused on the identification of the most-important somatic mutations ('major drivers') that cause tumour growth. However, many mutations found in cancer might not be major drivers or 'passenger' mutations, but instead might have relatively weak tumour-promoting effects. Our aim is to highlight the existence of these mutations (termed 'mini drivers' herein), as multiple mini-driver mutations might substitute for a major-driver change, especially in the presence of genomic instability or high mutagen exposure. The mini-driver model has clinical implications: for example, the effects of therapeutically targeting such genes may be limited. However, the main importance of the model lies in helping to provide a complete understanding of tumorigenesis, especially as we anticipate that an increasing number of mini-driver mutations will be found by cancer genome sequencing." @default.
- W2102859097 created "2016-06-24" @default.
- W2102859097 creator A5040598662 @default.
- W2102859097 creator A5064727417 @default.
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- W2102859097 date "2015-10-12" @default.
- W2102859097 modified "2023-10-17" @default.
- W2102859097 title "The mini-driver model of polygenic cancer evolution" @default.
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- W2102859097 doi "https://doi.org/10.1038/nrc3999" @default.
- W2102859097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26456849" @default.
- W2102859097 hasPublicationYear "2015" @default.
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