FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102871449> ?p ?o ?g. }

• W2102871449 endingPage "2617" @default.
• W2102871449 startingPage "2613" @default.
• W2102871449 abstract "Proliferative diabetic retinopathy (PDR) is the most severe vision-threatening complication of diabetes. For investigation of genetic association between TCF7L2 and PDR in Caucasian type 2 diabetes mellitus (T2DM) and its functional consequences, 383 T2DM patients with PDR (T2DM-PDR) and 756 T2DM patients without diabetic retinopathy (T2DM–no DR) were genotyped with rs7903146 in TCF7L2. We found that risk allele (T) frequency of rs7903146 was significantly higher in T2DM-PDR patients (allelic P = 2.52E-04). In lymphoblastoid cells induced to undergo endoplasmic reticulum (ER) stress by treatment of tunicamycin, higher fold change of TCF7L2 and VEGFA mRNA levels were observed in rs7903146-TT cells than in rs7903146-CC cells (P = 0.02 for TCF7L2; P = 0.004 for VEGFA), suggesting that ER stress plays a role in PDR pathogenesis. Silencing TCF7L2 resulted in decreased mRNA levels of both TCF7L2 and VEGFA (P &lt; 0.001). Retinas of oxygen-induced retinopathy mice (a model for PDR) had higher TCF7L2 and VEGFA mRNA levels than those of controls (P = 2.9E-04 for TCF7L2; P = 1.9E-07 for VEGFA). Together, data from our study show that TCF7L2-rs7903146 is associated with PDR in Caucasian T2DM and suggest that TCF7L2 promotes pathological retinal neovascularization via ER stress–dependent upregulation of VEGFA." @default.
• W2102871449 created "2016-06-24" @default.
• W2102871449 creator A5000068004 @default.
• W2102871449 creator A5020628503 @default.
• W2102871449 creator A5022962900 @default.
• W2102871449 creator A5024498267 @default.
• W2102871449 creator A5028289735 @default.
• W2102871449 creator A5029215938 @default.
• W2102871449 creator A5031543598 @default.
• W2102871449 creator A5044965320 @default.
• W2102871449 creator A5053139475 @default.
• W2102871449 creator A5067541352 @default.
• W2102871449 creator A5068312783 @default.
• W2102871449 creator A5071460109 @default.
• W2102871449 creator A5078009705 @default.
• W2102871449 creator A5079729144 @default.
• W2102871449 creator A5080616533 @default.
• W2102871449 creator A5087391390 @default.
• W2102871449 date "2013-06-14" @default.
• W2102871449 modified "2023-09-28" @default.
• W2102871449 title "<i>TCF7L2</i> Variation and Proliferative Diabetic Retinopathy" @default.
• W2102871449 cites W1965141016 @default.
• W2102871449 cites W1965929705 @default.
• W2102871449 cites W1973197740 @default.
• W2102871449 cites W1982966896 @default.
• W2102871449 cites W1984461274 @default.
• W2102871449 cites W2002025697 @default.
• W2102871449 cites W2004402671 @default.
• W2102871449 cites W2007078899 @default.
• W2102871449 cites W2016878020 @default.
• W2102871449 cites W2025010711 @default.
• W2102871449 cites W2066371063 @default.
• W2102871449 cites W2100741672 @default.
• W2102871449 cites W2106901733 @default.
• W2102871449 cites W2107222217 @default.
• W2102871449 cites W2116255975 @default.
• W2102871449 cites W2128403978 @default.
• W2102871449 cites W2140731000 @default.
• W2102871449 cites W2151014055 @default.
• W2102871449 cites W2162669241 @default.
• W2102871449 cites W2164194503 @default.
• W2102871449 cites W2164619163 @default.
• W2102871449 cites W2324588265 @default.
• W2102871449 cites W4235340502 @default.
• W2102871449 cites W4240633495 @default.
• W2102871449 doi "https://doi.org/10.2337/db12-1093" @default.
• W2102871449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3712060" @default.
• W2102871449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23434931" @default.
• W2102871449 hasPublicationYear "2013" @default.
• W2102871449 type Work @default.
• W2102871449 sameAs 2102871449 @default.
• W2102871449 citedByCount "36" @default.
• W2102871449 countsByYear W21028714492013 @default.
• W2102871449 countsByYear W21028714492014 @default.
• W2102871449 countsByYear W21028714492015 @default.
• W2102871449 countsByYear W21028714492016 @default.
• W2102871449 countsByYear W21028714492017 @default.
• W2102871449 countsByYear W21028714492018 @default.
• W2102871449 countsByYear W21028714492019 @default.
• W2102871449 countsByYear W21028714492020 @default.
• W2102871449 countsByYear W21028714492021 @default.
• W2102871449 countsByYear W21028714492022 @default.
• W2102871449 countsByYear W21028714492023 @default.
• W2102871449 crossrefType "journal-article" @default.
• W2102871449 hasAuthorship W2102871449A5000068004 @default.
• W2102871449 hasAuthorship W2102871449A5020628503 @default.
• W2102871449 hasAuthorship W2102871449A5022962900 @default.
• W2102871449 hasAuthorship W2102871449A5024498267 @default.
• W2102871449 hasAuthorship W2102871449A5028289735 @default.
• W2102871449 hasAuthorship W2102871449A5029215938 @default.
• W2102871449 hasAuthorship W2102871449A5031543598 @default.
• W2102871449 hasAuthorship W2102871449A5044965320 @default.
• W2102871449 hasAuthorship W2102871449A5053139475 @default.
• W2102871449 hasAuthorship W2102871449A5067541352 @default.
• W2102871449 hasAuthorship W2102871449A5068312783 @default.
• W2102871449 hasAuthorship W2102871449A5071460109 @default.
• W2102871449 hasAuthorship W2102871449A5078009705 @default.
• W2102871449 hasAuthorship W2102871449A5079729144 @default.
• W2102871449 hasAuthorship W2102871449A5080616533 @default.
• W2102871449 hasAuthorship W2102871449A5087391390 @default.
• W2102871449 hasBestOaLocation W21028714491 @default.
• W2102871449 hasConcept C104317684 @default.
• W2102871449 hasConcept C126322002 @default.
• W2102871449 hasConcept C127561419 @default.
• W2102871449 hasConcept C134018914 @default.
• W2102871449 hasConcept C135763542 @default.
• W2102871449 hasConcept C153209595 @default.
• W2102871449 hasConcept C2778313320 @default.
• W2102871449 hasConcept C2779829184 @default.
• W2102871449 hasConcept C39263347 @default.
• W2102871449 hasConcept C54355233 @default.
• W2102871449 hasConcept C555293320 @default.
• W2102871449 hasConcept C71924100 @default.
• W2102871449 hasConcept C86803240 @default.
• W2102871449 hasConceptScore W2102871449C104317684 @default.
• W2102871449 hasConceptScore W2102871449C126322002 @default.
• W2102871449 hasConceptScore W2102871449C127561419 @default.
• W2102871449 hasConceptScore W2102871449C134018914 @default.

• next