Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102879679> ?p ?o ?g. }
- W2102879679 endingPage "1156" @default.
- W2102879679 startingPage "1147" @default.
- W2102879679 abstract "Various cancers including skin cancer are increasing in 45 million people exposed to arsenic above the World Health Organization's guideline value of 10 μg l(-1). However, there is limited information on key molecules regulating arsenic-mediated carcinogenesis. Our fieldwork in Bangladesh demonstrated that levels of placental growth factor (PlGF) in urine samples from residents of cancer-prone areas with arsenic-polluted drinking water were higher than those in urine samples from residents of an area that was not polluted with arsenic. Our experimental study in human nontumorigenic HaCaT skin keratinocytes showed that arsenite promoted anchorage-independent growth with increased expression and secretion of PlGF, a ligand of vascular endothelial growth factor receptor1 (VEGFR1), and increased VEGFR1/mitogen-activated protein kinase/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) activities. The arsenite-mediated promotion of anchorage-independent growth was strongly inhibited by PlGF depletion with decreased activities of the PlGF/VEGFR1/MEK/ERK pathway. Moreover, arsenite proteasome-dependently degrades metal-regulatory transcription factor-1 (MTF-1) protein, resulting in a decreased amount of MTF-1 protein binding to the PlGF promoter. MTF-1 negatively controlled PlGF transcription in HaCaT cells, resulting in increased PlGF transcription. These results suggest that arsenite-mediated MTF-1 degradation enhances the activity of PlGF/VEGFR1/MEK/ERK signaling, resulting in promotion of the malignant transformation of keratinocytes. Thus, this study proposed a molecular mechanism for arsenite-mediated development of skin cancer." @default.
- W2102879679 created "2016-06-24" @default.
- W2102879679 creator A5002672324 @default.
- W2102879679 creator A5010122783 @default.
- W2102879679 creator A5028793080 @default.
- W2102879679 creator A5048991469 @default.
- W2102879679 creator A5070163946 @default.
- W2102879679 creator A5072269058 @default.
- W2102879679 creator A5089659648 @default.
- W2102879679 creator A5089988781 @default.
- W2102879679 date "2015-04-01" @default.
- W2102879679 modified "2023-10-13" @default.
- W2102879679 title "Arsenite-Mediated Promotion of Anchorage-Independent Growth of HaCaT Cells through Placental Growth Factor" @default.
- W2102879679 cites W1551640058 @default.
- W2102879679 cites W1599690431 @default.
- W2102879679 cites W1644156898 @default.
- W2102879679 cites W1875554126 @default.
- W2102879679 cites W1927414006 @default.
- W2102879679 cites W1966676932 @default.
- W2102879679 cites W1968074857 @default.
- W2102879679 cites W1972305678 @default.
- W2102879679 cites W1974588461 @default.
- W2102879679 cites W1975169642 @default.
- W2102879679 cites W1980033442 @default.
- W2102879679 cites W1992444784 @default.
- W2102879679 cites W1993168796 @default.
- W2102879679 cites W1993356092 @default.
- W2102879679 cites W1995599327 @default.
- W2102879679 cites W1995726629 @default.
- W2102879679 cites W2003801328 @default.
- W2102879679 cites W2009514486 @default.
- W2102879679 cites W2014148719 @default.
- W2102879679 cites W2017133886 @default.
- W2102879679 cites W2035855654 @default.
- W2102879679 cites W2036009794 @default.
- W2102879679 cites W2049320716 @default.
- W2102879679 cites W2051268134 @default.
- W2102879679 cites W2053026927 @default.
- W2102879679 cites W2054963404 @default.
- W2102879679 cites W2055177952 @default.
- W2102879679 cites W2057379707 @default.
- W2102879679 cites W2063972093 @default.
- W2102879679 cites W2066345054 @default.
- W2102879679 cites W2068334012 @default.
- W2102879679 cites W2068494549 @default.
- W2102879679 cites W2088796595 @default.
- W2102879679 cites W2091440687 @default.
- W2102879679 cites W2104009634 @default.
- W2102879679 cites W2119281341 @default.
- W2102879679 cites W2143464311 @default.
- W2102879679 cites W2146328465 @default.
- W2102879679 cites W2150365605 @default.
- W2102879679 cites W2162262059 @default.
- W2102879679 cites W2163921882 @default.
- W2102879679 cites W2168613545 @default.
- W2102879679 cites W4291980969 @default.
- W2102879679 cites W4301522780 @default.
- W2102879679 cites W1589935525 @default.
- W2102879679 doi "https://doi.org/10.1038/jid.2014.514" @default.
- W2102879679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25493652" @default.
- W2102879679 hasPublicationYear "2015" @default.
- W2102879679 type Work @default.
- W2102879679 sameAs 2102879679 @default.
- W2102879679 citedByCount "21" @default.
- W2102879679 countsByYear W21028796792015 @default.
- W2102879679 countsByYear W21028796792016 @default.
- W2102879679 countsByYear W21028796792017 @default.
- W2102879679 countsByYear W21028796792018 @default.
- W2102879679 countsByYear W21028796792019 @default.
- W2102879679 countsByYear W21028796792020 @default.
- W2102879679 countsByYear W21028796792021 @default.
- W2102879679 countsByYear W21028796792022 @default.
- W2102879679 countsByYear W21028796792023 @default.
- W2102879679 crossrefType "journal-article" @default.
- W2102879679 hasAuthorship W2102879679A5002672324 @default.
- W2102879679 hasAuthorship W2102879679A5010122783 @default.
- W2102879679 hasAuthorship W2102879679A5028793080 @default.
- W2102879679 hasAuthorship W2102879679A5048991469 @default.
- W2102879679 hasAuthorship W2102879679A5070163946 @default.
- W2102879679 hasAuthorship W2102879679A5072269058 @default.
- W2102879679 hasAuthorship W2102879679A5089659648 @default.
- W2102879679 hasAuthorship W2102879679A5089988781 @default.
- W2102879679 hasBestOaLocation W21028796791 @default.
- W2102879679 hasConcept C104317684 @default.
- W2102879679 hasConcept C118995209 @default.
- W2102879679 hasConcept C121608353 @default.
- W2102879679 hasConcept C126322002 @default.
- W2102879679 hasConcept C167734588 @default.
- W2102879679 hasConcept C178790620 @default.
- W2102879679 hasConcept C184235292 @default.
- W2102879679 hasConcept C185592680 @default.
- W2102879679 hasConcept C2776305511 @default.
- W2102879679 hasConcept C2776871010 @default.
- W2102879679 hasConcept C2777025900 @default.
- W2102879679 hasConcept C2780122803 @default.
- W2102879679 hasConcept C502230775 @default.
- W2102879679 hasConcept C502942594 @default.
- W2102879679 hasConcept C54355233 @default.