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- W2102906849 abstract "Introduction: It is known that both normoxic heliox and pure oxygen breathing significantly increase locomotor O 2 delivery during exercise in COPD. However, it remains unknown which of the two gases is the most beneficial in terms of enhancing exercise tolerance and locomotor muscle O 2 availability. Methods: 12 COPD patients [FEV 1 =42±12%pred] performed 3 constant-load exercise tests at 75% of maximum work rate while breathing air, normoxic heliox or pure O 2 . We measured cardiac output (Fick method), haemodynamic responses, quadriceps muscle blood flow by near infrared spectroscopy with ICG dye and changes in quadriceps muscle deoxygenation ([HHb], an index of fractional O 2 extraction) at the transition from rest to exercise (on-kinetics). Results: Exercise endurance time was not significantly different between heliox and O 2 [ ( mean±SEM ) He: 637±46 vs O 2 : 670±43 vs Air: 394±35 s] . Peak cardiac output was significantly greater on heliox (He: 9.3±0.5 vs O 2 : 8.2±0.6 vs air: 8.9 l/min) but O 2 caused a significant greater elevation of arterial oxygen content (He: 183±6 vs O 2 : 213±7 vs air: 180±5 ml/min). However, neither quadriceps muscle blood flow (He: 32±5 vs O 2 : 31±6 vs Air: 22±5 ml/min/100gr) nor quadriceps O 2 delivery (He: 5.8±0.9 vs O 2 : 6.3±1.1 vs Air: 3.9±0.8 ml O 2 /min/100gr) were significantly different between heliox and O 2 . Mean response time of deoxygenated HHb on heliox (MRT=18.1±1.7s) and O 2 (MRT=17.4 ± 1.4s ) were not significantly different but were both greater compared to air (MRT=13.8±1.3s) (P Conclusion: Supplementation of heliox or O 2 is equally beneficial in terms of enhancing exercise tolerance and locomotor muscle O 2 availability during exercise in COPD." @default.
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- W2102906849 date "2011-09-01" @default.
- W2102906849 modified "2023-10-02" @default.
- W2102906849 title "Evaluation of heliox or oxygen breathing on improved quadriceps muscle oxygen delivery during exercise in COPD" @default.
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