FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102907110> ?p ?o ?g. }

• W2102907110 endingPage "302" @default.
• W2102907110 startingPage "291" @default.
• W2102907110 abstract "ABSTRACT Cultured cells of Eschscholzia californica respond to a yeast glycoprotein elicitor by producing benzophenanthridine alkaloids, which are excreted into the cell wall and the outer medium. These compounds, preferentially sanguinarine, are efficient phytoalexins because of their ability to intercalate double‐stranded DNA (dsDNA), penetrate membranes and inhibit various enzymes containing SH‐groups. Externally added sanguinarine is rapidly taken up by intact cells and converted to dihydrosanguinarine, which is substituted intracellularly according to the biosynthetic route. A 29.5 kDa soluble enzyme that catalyses the reduction of sanguinarine and chelerythrine by either NADPH or NADH has been isolated and purified to homogeneity. Benzophenanthridines that accumulate in the outer medium, mainly 10‐OH‐chelerythrine, chelirubine and macarpine, are converted by the isolated enzyme and by intact cells at much slower rates than sanguinarine. The cellular capacity of uptake and conversion of sanguinarine largely surpasses the rate of alkaloid production. We conclude that the sanguinarine produced by intact cells, after excretion and binding to cell wall elements, is rapidly reabsorbed and reduced to the less toxic dihydrosanguinarine, which then undergoes further biosynthetic reactions. This recycling process would allow the presence of the toxic phytoalexin at the cellular surface without taking the risk of injuring the producing cell." @default.
• W2102907110 created "2016-06-24" @default.
• W2102907110 creator A5019686494 @default.
• W2102907110 creator A5033886882 @default.
• W2102907110 creator A5050626074 @default.
• W2102907110 creator A5074017625 @default.
• W2102907110 date "2005-10-25" @default.
• W2102907110 modified "2023-10-10" @default.
• W2102907110 title "Sanguinarine reductase, a key enzyme of benzophenanthridine detoxification" @default.
• W2102907110 cites W120489749 @default.
• W2102907110 cites W1549234286 @default.
• W2102907110 cites W1591448766 @default.
• W2102907110 cites W1963917720 @default.
• W2102907110 cites W1967118561 @default.
• W2102907110 cites W1969586730 @default.
• W2102907110 cites W1969669735 @default.
• W2102907110 cites W1978104741 @default.
• W2102907110 cites W1981971885 @default.
• W2102907110 cites W1983065030 @default.
• W2102907110 cites W1985325949 @default.
• W2102907110 cites W1986235720 @default.
• W2102907110 cites W1986963239 @default.
• W2102907110 cites W1989783281 @default.
• W2102907110 cites W1994087266 @default.
• W2102907110 cites W2005038450 @default.
• W2102907110 cites W2008988821 @default.
• W2102907110 cites W2011262783 @default.
• W2102907110 cites W2011465357 @default.
• W2102907110 cites W2012401191 @default.
• W2102907110 cites W2014590642 @default.
• W2102907110 cites W2020449416 @default.
• W2102907110 cites W2024597420 @default.
• W2102907110 cites W2034541138 @default.
• W2102907110 cites W2036846777 @default.
• W2102907110 cites W2041175802 @default.
• W2102907110 cites W2050615514 @default.
• W2102907110 cites W2050709067 @default.
• W2102907110 cites W2054101398 @default.
• W2102907110 cites W2055608658 @default.
• W2102907110 cites W2089296290 @default.
• W2102907110 cites W2091465863 @default.
• W2102907110 cites W2093863629 @default.
• W2102907110 cites W2109324504 @default.
• W2102907110 cites W2119246940 @default.
• W2102907110 cites W2159261059 @default.
• W2102907110 cites W2170844079 @default.
• W2102907110 cites W2196878903 @default.
• W2102907110 doi "https://doi.org/10.1111/j.1365-3040.2005.01421.x" @default.
• W2102907110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17080644" @default.
• W2102907110 hasPublicationYear "2005" @default.
• W2102907110 type Work @default.
• W2102907110 sameAs 2102907110 @default.
• W2102907110 citedByCount "59" @default.
• W2102907110 countsByYear W21029071102012 @default.
• W2102907110 countsByYear W21029071102013 @default.
• W2102907110 countsByYear W21029071102014 @default.
• W2102907110 countsByYear W21029071102015 @default.
• W2102907110 countsByYear W21029071102016 @default.
• W2102907110 countsByYear W21029071102017 @default.
• W2102907110 countsByYear W21029071102018 @default.
• W2102907110 countsByYear W21029071102019 @default.
• W2102907110 countsByYear W21029071102020 @default.
• W2102907110 countsByYear W21029071102021 @default.
• W2102907110 countsByYear W21029071102022 @default.
• W2102907110 crossrefType "journal-article" @default.
• W2102907110 hasAuthorship W2102907110A5019686494 @default.
• W2102907110 hasAuthorship W2102907110A5033886882 @default.
• W2102907110 hasAuthorship W2102907110A5050626074 @default.
• W2102907110 hasAuthorship W2102907110A5074017625 @default.
• W2102907110 hasBestOaLocation W21029071101 @default.
• W2102907110 hasConcept C181199279 @default.
• W2102907110 hasConcept C185592680 @default.
• W2102907110 hasConcept C195794163 @default.
• W2102907110 hasConcept C2776108454 @default.
• W2102907110 hasConcept C2776816829 @default.
• W2102907110 hasConcept C2777667214 @default.
• W2102907110 hasConcept C2778046504 @default.
• W2102907110 hasConcept C2778751241 @default.
• W2102907110 hasConcept C2778920010 @default.
• W2102907110 hasConcept C2779012821 @default.
• W2102907110 hasConcept C55493867 @default.
• W2102907110 hasConcept C59822182 @default.
• W2102907110 hasConcept C86803240 @default.
• W2102907110 hasConceptScore W2102907110C181199279 @default.
• W2102907110 hasConceptScore W2102907110C185592680 @default.
• W2102907110 hasConceptScore W2102907110C195794163 @default.
• W2102907110 hasConceptScore W2102907110C2776108454 @default.
• W2102907110 hasConceptScore W2102907110C2776816829 @default.
• W2102907110 hasConceptScore W2102907110C2777667214 @default.
• W2102907110 hasConceptScore W2102907110C2778046504 @default.
• W2102907110 hasConceptScore W2102907110C2778751241 @default.
• W2102907110 hasConceptScore W2102907110C2778920010 @default.
• W2102907110 hasConceptScore W2102907110C2779012821 @default.
• W2102907110 hasConceptScore W2102907110C55493867 @default.
• W2102907110 hasConceptScore W2102907110C59822182 @default.
• W2102907110 hasConceptScore W2102907110C86803240 @default.
• W2102907110 hasIssue "2" @default.
• W2102907110 hasLocation W21029071101 @default.

• next