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- W2102911895 abstract "Type 2 diabetes mellitus(DM2) and polypharmacy can affect the health related quality of life(HRQoL). A new 5-level version of EQ5D instrument is available; it is therefore interesting to evaluate its performance compared to previous EQ5D-3L. Cross-sectional study of baseline data from a cohort of DM2 patients taking 5 or more drugs (313 patients from a randomized clinical trial to prevent drug inadequacy in DM2 patients). HRQoL was measured using EQ5D-5L instrument and compared to previous EQ5D-3L data from a similar population. Patient socio-demographic data, number and nature of prescribed drugs and HbA1c serum levels were collected; their associations to variations in HRQoL were assessed. EQ5D-5L utilities were elicited thru 5L-3L EuroQoL crosswalking value set. Cronbach's alpha was used to evaluate reliability of EQ5D-5L in this sample, and Spearman's rho coefficient for correlations. Mean age at index date was 71 years, 57.2% were male and 75.7% were 65 years or older. Mean HbA1c was 7.2%[SD:1.3], 22.4% were taking insulin and 51.6% had a good control of their diabetes. On average patients were taking 9.4 drugs[SD:3.8; range:5-23]. Most affected EQ5D dimensions were mobility and pain/discomfort (more than half of respondents reporting problems). Mean EQ5D utility index was 0.786[SD:0.224; range:−0.224 to 1]. Bad glycemic control (HbA1c≥7%), use of insulin and a greater number of drugs were all associated to a poorer HRQoL. EQ5D index was negatively correlated with the number of prescribed drugs(r=−0.34; p<0.01), but no correlation was found with age or HbA1c. EQ5D-5L showed good reliability (α=0.77) and less ceiling (23.3%) and floor (0.3%) effects than 3L. There was a better discrimination capacity for punctuations in each of the 5 dimensions. DM2 patients with polypharmacy showed a diminished HRQoL, negatively correlated to the number of prescribed medicines; the new EQ5D-5L appears to exhibit better discriminatory properties than the traditional EQ5D-3L." @default.
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- W2102911895 date "2012-11-01" @default.
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- W2102911895 title "PRM103 Estimating Health Related Quality in Type 2 Diabetic Patients Receiving Polytherapy With EQ5D-5L Questionnaire" @default.
- W2102911895 doi "https://doi.org/10.1016/j.jval.2012.08.1566" @default.
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