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• W2102912402 abstract "Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease. In this study we investigated effects of activin A binding to receptors that are shared with BMPs using myeloma cell lines with well-characterized BMP-receptor expression and responses. Activin A antagonized BMP-6 and BMP-9, but not BMP-2 and BMP-4. Activin A was able to counteract BMPs that signal through the type 2 receptors ACVR2A and ACVR2B in combination with ALK2, but not BMPs that signal through BMPR2 in combination with ALK3 and ALK6. We propose that one important way that activin A regulates cell behavior is by antagonizing BMP-ACVR2A/ACVR2B/ALK2 signaling." @default.
• W2102912402 created "2016-06-24" @default.
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• W2102912402 date "2015-06-06" @default.
• W2102912402 modified "2023-10-01" @default.
• W2102912402 title "Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B" @default.
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• W2102912402 doi "https://doi.org/10.1186/s12964-015-0104-z" @default.
• W2102912402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4467681" @default.
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