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- W2102912697 abstract "The number of cells in the G1, S, G2, or M phase of the cell cycle varies with the stage of tumor growth. During exponential growth, many of the cells take up and are labeled by tritiated thymidine and therefore are in S phase. During the middle stages of tumor growth, the DNA per cell rose and fell coincident with the amount of label uptake. This is consistent with an age cohort composition favoring S, G2, and M phase cells. In the advanced tumor, or terminal animal, cell proliferation was greatly reduced and most of the cells appeared to collect in the G1 phase. Antimetabolite therapy with hydroxyurea and 5-fluoro-uricil was most effective when DNA synthetic activity was greatest." @default.
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- W2102912697 date "1973-10-01" @default.
- W2102912697 modified "2023-09-23" @default.
- W2102912697 title "Age Cohort Variation of Tumor Cells" @default.
- W2102912697 doi "https://doi.org/10.1148/109.1.213" @default.
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