FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102922010> ?p ?o ?g. }

• W2102922010 endingPage "34" @default.
• W2102922010 startingPage "27" @default.
• W2102922010 abstract "Type IIa sodium-dependent phosphate transporter (NaPi-IIa) is responsible for renal phosphate reabsorption and maintenance of systemic phosphate homeostasis in mammals. Macromolecular complex formation of NaPi-IIa with sodium-proton exchanger related factor-1 (NHERF-1) and ezrin is important for apical membrane localization in the proximal tubular cells. Here, we investigated the interactions of the ezrin phosphomimetic mutation of serine to aspartic acid at 249 with NHERF-1 and the inhibition of apical membrane localization of NaPi-IIa. In vitro phosphorylation analysis revealed that serine 249 of human ezrin serves as a phosphorylation site for protein kinase A. The N-terminal half of ezrin had a dominant negative effect on the phosphate transport activity and inhibited the apical localization of NaPi-IIa in renal proximal tubular cells. We found that the phosphomimetic S249D mutant interfered with the inhibitory effects of the dominant negative mutant on the transport and localization of NaPi-IIa. The S249D mutant also inhibited the interaction with NHERF-1. Therefore, serine 249 of ezrin can play important roles in the regulation of the complex formation and membrane localization of NaPi-IIa." @default.
• W2102922010 created "2016-06-24" @default.
• W2102922010 creator A5001620097 @default.
• W2102922010 creator A5047877300 @default.
• W2102922010 creator A5055461853 @default.
• W2102922010 creator A5061645253 @default.
• W2102922010 creator A5064890597 @default.
• W2102922010 creator A5069476050 @default.
• W2102922010 creator A5071110101 @default.
• W2102922010 creator A5072852260 @default.
• W2102922010 creator A5073465990 @default.
• W2102922010 creator A5089275347 @default.
• W2102922010 date "2013-01-01" @default.
• W2102922010 modified "2023-10-18" @default.
• W2102922010 title "Role of serine 249 of ezrin in the regulation of sodium-dependent phosphate transporter NaPi-IIa activity in renal proximal tubular cells" @default.
• W2102922010 cites W1974327314 @default.
• W2102922010 cites W1986531677 @default.
• W2102922010 cites W1999996046 @default.
• W2102922010 cites W2015599341 @default.
• W2102922010 cites W2021539438 @default.
• W2102922010 cites W2054007424 @default.
• W2102922010 cites W2068208625 @default.
• W2102922010 cites W2072128091 @default.
• W2102922010 cites W2091559752 @default.
• W2102922010 cites W2106851548 @default.
• W2102922010 cites W2107878287 @default.
• W2102922010 cites W2109466583 @default.
• W2102922010 cites W2112981236 @default.
• W2102922010 cites W2113737776 @default.
• W2102922010 cites W2156592613 @default.
• W2102922010 cites W2161630557 @default.
• W2102922010 cites W2183657089 @default.
• W2102922010 cites W2185738569 @default.
• W2102922010 doi "https://doi.org/10.2152/jmi.60.27" @default.
• W2102922010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23614908" @default.
• W2102922010 hasPublicationYear "2013" @default.
• W2102922010 type Work @default.
• W2102922010 sameAs 2102922010 @default.
• W2102922010 citedByCount "5" @default.
• W2102922010 countsByYear W21029220102013 @default.
• W2102922010 countsByYear W21029220102019 @default.
• W2102922010 countsByYear W21029220102021 @default.
• W2102922010 countsByYear W21029220102022 @default.
• W2102922010 crossrefType "journal-article" @default.
• W2102922010 hasAuthorship W2102922010A5001620097 @default.
• W2102922010 hasAuthorship W2102922010A5047877300 @default.
• W2102922010 hasAuthorship W2102922010A5055461853 @default.
• W2102922010 hasAuthorship W2102922010A5061645253 @default.
• W2102922010 hasAuthorship W2102922010A5064890597 @default.
• W2102922010 hasAuthorship W2102922010A5069476050 @default.
• W2102922010 hasAuthorship W2102922010A5071110101 @default.
• W2102922010 hasAuthorship W2102922010A5072852260 @default.
• W2102922010 hasAuthorship W2102922010A5073465990 @default.
• W2102922010 hasAuthorship W2102922010A5089275347 @default.
• W2102922010 hasBestOaLocation W21029220101 @default.
• W2102922010 hasConcept C104317684 @default.
• W2102922010 hasConcept C11960822 @default.
• W2102922010 hasConcept C120405084 @default.
• W2102922010 hasConcept C142669718 @default.
• W2102922010 hasConcept C143065580 @default.
• W2102922010 hasConcept C149011108 @default.
• W2102922010 hasConcept C1491633281 @default.
• W2102922010 hasConcept C178790620 @default.
• W2102922010 hasConcept C184235292 @default.
• W2102922010 hasConcept C185592680 @default.
• W2102922010 hasConcept C188053792 @default.
• W2102922010 hasConcept C2776414213 @default.
• W2102922010 hasConcept C2780246058 @default.
• W2102922010 hasConcept C537181965 @default.
• W2102922010 hasConcept C55493867 @default.
• W2102922010 hasConcept C56906281 @default.
• W2102922010 hasConcept C63645605 @default.
• W2102922010 hasConcept C86803240 @default.
• W2102922010 hasConcept C95444343 @default.
• W2102922010 hasConceptScore W2102922010C104317684 @default.
• W2102922010 hasConceptScore W2102922010C11960822 @default.
• W2102922010 hasConceptScore W2102922010C120405084 @default.
• W2102922010 hasConceptScore W2102922010C142669718 @default.
• W2102922010 hasConceptScore W2102922010C143065580 @default.
• W2102922010 hasConceptScore W2102922010C149011108 @default.
• W2102922010 hasConceptScore W2102922010C1491633281 @default.
• W2102922010 hasConceptScore W2102922010C178790620 @default.
• W2102922010 hasConceptScore W2102922010C184235292 @default.
• W2102922010 hasConceptScore W2102922010C185592680 @default.
• W2102922010 hasConceptScore W2102922010C188053792 @default.
• W2102922010 hasConceptScore W2102922010C2776414213 @default.
• W2102922010 hasConceptScore W2102922010C2780246058 @default.
• W2102922010 hasConceptScore W2102922010C537181965 @default.
• W2102922010 hasConceptScore W2102922010C55493867 @default.
• W2102922010 hasConceptScore W2102922010C56906281 @default.
• W2102922010 hasConceptScore W2102922010C63645605 @default.
• W2102922010 hasConceptScore W2102922010C86803240 @default.
• W2102922010 hasConceptScore W2102922010C95444343 @default.
• W2102922010 hasIssue "1.2" @default.
• W2102922010 hasLocation W21029220101 @default.
• W2102922010 hasLocation W21029220102 @default.
• W2102922010 hasOpenAccess W2102922010 @default.
• W2102922010 hasPrimaryLocation W21029220101 @default.

• next