Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102923902> ?p ?o ?g. }
- W2102923902 abstract "African trypanosomes are sustained in the bloodstream of their mammalian hosts by their extreme capacity for antigenic variation. However, for life cycle progression, trypanosomes also must generate transmission stages called stumpy forms that are pre-adapted to survive when taken up during the bloodmeal of the disease vector, tsetse flies. These stumpy forms are rather different to the proliferative slender forms that maintain the bloodstream parasitaemia. Firstly, they are non proliferative and morphologically distinct, secondly, they show particular sensitivity to environmental cues that signal entry to the tsetse fly and, thirdly, they are relatively robust such that they survive the changes in temperature, pH and proteolytic environment encountered within the tsetse midgut. These characteristics require regulated changes in gene expression to pre-adapt the parasite and the use of environmental sensing mechanisms, both of which allow the rapid initiation of differentiation to tsetse midgut procyclic forms upon transmission. Interestingly, the generation of stumpy forms is also regulated and periodic in the mammalian blood, this being governed by a density-sensing mechanism whereby a parasite-derived signal drives cell cycle arrest and cellular development both to optimise transmission and to prevent uncontrolled parasite multiplication overwhelming the host. In this review we detail recent developments in our understanding of the molecular mechanisms that underpin the production of stumpy forms in the mammalian bloodstream and their signal perception pathways both in the mammalian bloodstream and upon entry into the tsetse fly. These discoveries are discussed in the context of conserved eukaryotic signalling and differentiation mechanisms. Further, their potential to act as targets for therapeutic strategies that disrupt parasite development either in the mammalian bloodstream or upon their transmission to tsetse flies is also discussed." @default.
- W2102923902 created "2016-06-24" @default.
- W2102923902 creator A5005777264 @default.
- W2102923902 creator A5028531312 @default.
- W2102923902 creator A5032603326 @default.
- W2102923902 creator A5043187706 @default.
- W2102923902 creator A5063062799 @default.
- W2102923902 creator A5063241264 @default.
- W2102923902 date "2013-01-01" @default.
- W2102923902 modified "2023-10-14" @default.
- W2102923902 title "Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei" @default.
- W2102923902 cites W1506602661 @default.
- W2102923902 cites W1522148501 @default.
- W2102923902 cites W1533788692 @default.
- W2102923902 cites W1560190501 @default.
- W2102923902 cites W1639836439 @default.
- W2102923902 cites W1732368748 @default.
- W2102923902 cites W1902677919 @default.
- W2102923902 cites W1919951605 @default.
- W2102923902 cites W1964702011 @default.
- W2102923902 cites W1966014320 @default.
- W2102923902 cites W1966055091 @default.
- W2102923902 cites W1966116745 @default.
- W2102923902 cites W1967775530 @default.
- W2102923902 cites W1967798372 @default.
- W2102923902 cites W1968516856 @default.
- W2102923902 cites W1970341475 @default.
- W2102923902 cites W1971581505 @default.
- W2102923902 cites W1973258411 @default.
- W2102923902 cites W1973603631 @default.
- W2102923902 cites W1974223831 @default.
- W2102923902 cites W1974877208 @default.
- W2102923902 cites W1976776701 @default.
- W2102923902 cites W1979015967 @default.
- W2102923902 cites W1984529935 @default.
- W2102923902 cites W1991586721 @default.
- W2102923902 cites W1991923259 @default.
- W2102923902 cites W1993338876 @default.
- W2102923902 cites W1995867836 @default.
- W2102923902 cites W1996518652 @default.
- W2102923902 cites W1997323235 @default.
- W2102923902 cites W1999591553 @default.
- W2102923902 cites W2000142729 @default.
- W2102923902 cites W2001290124 @default.
- W2102923902 cites W2002507130 @default.
- W2102923902 cites W2002718082 @default.
- W2102923902 cites W2003783312 @default.
- W2102923902 cites W2006285998 @default.
- W2102923902 cites W2007167713 @default.
- W2102923902 cites W2016023358 @default.
- W2102923902 cites W2017685664 @default.
- W2102923902 cites W2018122290 @default.
- W2102923902 cites W2018633705 @default.
- W2102923902 cites W2018874441 @default.
- W2102923902 cites W2020308781 @default.
- W2102923902 cites W2022077055 @default.
- W2102923902 cites W2025191415 @default.
- W2102923902 cites W2025277548 @default.
- W2102923902 cites W2029303106 @default.
- W2102923902 cites W2029667773 @default.
- W2102923902 cites W2030923116 @default.
- W2102923902 cites W2033895186 @default.
- W2102923902 cites W2033935980 @default.
- W2102923902 cites W2035397174 @default.
- W2102923902 cites W2035989713 @default.
- W2102923902 cites W2036648344 @default.
- W2102923902 cites W2037427849 @default.
- W2102923902 cites W2038082139 @default.
- W2102923902 cites W2038694386 @default.
- W2102923902 cites W2040856541 @default.
- W2102923902 cites W2042699443 @default.
- W2102923902 cites W2047571226 @default.
- W2102923902 cites W2054934898 @default.
- W2102923902 cites W2056960490 @default.
- W2102923902 cites W2058498493 @default.
- W2102923902 cites W2058688629 @default.
- W2102923902 cites W2058925385 @default.
- W2102923902 cites W2060874273 @default.
- W2102923902 cites W2064410706 @default.
- W2102923902 cites W2064879739 @default.
- W2102923902 cites W2066635070 @default.
- W2102923902 cites W2073689323 @default.
- W2102923902 cites W2074286661 @default.
- W2102923902 cites W2077116066 @default.
- W2102923902 cites W2078937868 @default.
- W2102923902 cites W2081148619 @default.
- W2102923902 cites W2082919092 @default.
- W2102923902 cites W2099591523 @default.
- W2102923902 cites W2099616490 @default.
- W2102923902 cites W2101232391 @default.
- W2102923902 cites W2101812996 @default.
- W2102923902 cites W2102517059 @default.
- W2102923902 cites W2102904980 @default.
- W2102923902 cites W2107260976 @default.
- W2102923902 cites W2107332260 @default.
- W2102923902 cites W2107762253 @default.
- W2102923902 cites W2108555971 @default.
- W2102923902 cites W2118510242 @default.
- W2102923902 cites W2121991815 @default.
- W2102923902 cites W2123210059 @default.