Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102927661> ?p ?o ?g. }
- W2102927661 abstract "The precise role of environment-gene interactions (epigenetics) in the development and progression of Alzheimer’s disease (AD) is unclear. This review focuses on the premise that radiotracer-specific PET imaging allows clinicians to visualize epigenetically influenced events and that such imaging may provide new, valuable insights for preventing, diagnosing, and treating AD. Current understanding of the role of epigenetics in AD and the principles underlying the use of PET radiotracers for in vivo diagnosis are reviewed. The relative efficacies of various PET radiotracers for visualizing the epigenetic influences on AD and their use for diagnosis are discussed. For example, [ 18 F]FAHA demonstrates sites of differential HDAC activity, [ 18 F]FDG indirectly illuminates sites of neuronal hypomethylation, and the carbon-11 isotope-containing Pittsburgh compound B ([ 11 C]PiB) images amyloid-beta plaque deposits. A definitive AD diagnosis is currently achievable only by postmortem histological observation of amyloid-beta plaques and tau neurofibrillary tangles. Therefore, reliable in vivo neuroimaging techniques could provide opportunities for early diagnosis and treatment of AD." @default.
- W2102927661 created "2016-06-24" @default.
- W2102927661 creator A5000726726 @default.
- W2102927661 creator A5003015144 @default.
- W2102927661 date "2015-01-01" @default.
- W2102927661 modified "2023-09-26" @default.
- W2102927661 title "PET Imaging of Epigenetic Influences on Alzheimer’s Disease" @default.
- W2102927661 cites W114676935 @default.
- W2102927661 cites W1211983638 @default.
- W2102927661 cites W1490067609 @default.
- W2102927661 cites W1548370718 @default.
- W2102927661 cites W1610736126 @default.
- W2102927661 cites W1644011132 @default.
- W2102927661 cites W1855414735 @default.
- W2102927661 cites W1890008664 @default.
- W2102927661 cites W1963599567 @default.
- W2102927661 cites W1970211293 @default.
- W2102927661 cites W1972100007 @default.
- W2102927661 cites W1978205433 @default.
- W2102927661 cites W1984644214 @default.
- W2102927661 cites W1992138808 @default.
- W2102927661 cites W1993598577 @default.
- W2102927661 cites W1995695796 @default.
- W2102927661 cites W1998117007 @default.
- W2102927661 cites W2001687789 @default.
- W2102927661 cites W2007764345 @default.
- W2102927661 cites W2008654792 @default.
- W2102927661 cites W2013033579 @default.
- W2102927661 cites W2015001118 @default.
- W2102927661 cites W2016193689 @default.
- W2102927661 cites W2017550829 @default.
- W2102927661 cites W2020089910 @default.
- W2102927661 cites W2023852811 @default.
- W2102927661 cites W2025021126 @default.
- W2102927661 cites W2032785128 @default.
- W2102927661 cites W2035613313 @default.
- W2102927661 cites W2037403969 @default.
- W2102927661 cites W2039069312 @default.
- W2102927661 cites W2051357376 @default.
- W2102927661 cites W2059597342 @default.
- W2102927661 cites W2061837100 @default.
- W2102927661 cites W2064861163 @default.
- W2102927661 cites W2065437875 @default.
- W2102927661 cites W2065475035 @default.
- W2102927661 cites W2069503557 @default.
- W2102927661 cites W2069613314 @default.
- W2102927661 cites W2070484780 @default.
- W2102927661 cites W2074274706 @default.
- W2102927661 cites W2079409065 @default.
- W2102927661 cites W2082808678 @default.
- W2102927661 cites W2086358075 @default.
- W2102927661 cites W2087366857 @default.
- W2102927661 cites W2088685810 @default.
- W2102927661 cites W2093022413 @default.
- W2102927661 cites W2103346709 @default.
- W2102927661 cites W2104300763 @default.
- W2102927661 cites W2109727228 @default.
- W2102927661 cites W2114353725 @default.
- W2102927661 cites W2114624568 @default.
- W2102927661 cites W2116030076 @default.
- W2102927661 cites W2116093994 @default.
- W2102927661 cites W2121673076 @default.
- W2102927661 cites W2123338808 @default.
- W2102927661 cites W2128581044 @default.
- W2102927661 cites W2128740541 @default.
- W2102927661 cites W2129771097 @default.
- W2102927661 cites W2132680220 @default.
- W2102927661 cites W2134555277 @default.
- W2102927661 cites W2137777161 @default.
- W2102927661 cites W2140348797 @default.
- W2102927661 cites W2145328569 @default.
- W2102927661 cites W2148437789 @default.
- W2102927661 cites W2152426966 @default.
- W2102927661 cites W2156676300 @default.
- W2102927661 cites W2160898573 @default.
- W2102927661 cites W2161942127 @default.
- W2102927661 cites W2170937822 @default.
- W2102927661 cites W2811340222 @default.
- W2102927661 cites W3161327343 @default.
- W2102927661 cites W4251353493 @default.
- W2102927661 doi "https://doi.org/10.1155/2015/575078" @default.
- W2102927661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4633540" @default.
- W2102927661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26600964" @default.
- W2102927661 hasPublicationYear "2015" @default.
- W2102927661 type Work @default.
- W2102927661 sameAs 2102927661 @default.
- W2102927661 citedByCount "11" @default.
- W2102927661 countsByYear W21029276612015 @default.
- W2102927661 countsByYear W21029276612016 @default.
- W2102927661 countsByYear W21029276612017 @default.
- W2102927661 countsByYear W21029276612018 @default.
- W2102927661 countsByYear W21029276612019 @default.
- W2102927661 countsByYear W21029276612020 @default.
- W2102927661 countsByYear W21029276612021 @default.
- W2102927661 countsByYear W21029276612022 @default.
- W2102927661 countsByYear W21029276612023 @default.
- W2102927661 crossrefType "journal-article" @default.
- W2102927661 hasAuthorship W2102927661A5000726726 @default.
- W2102927661 hasAuthorship W2102927661A5003015144 @default.
- W2102927661 hasBestOaLocation W21029276611 @default.