Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102935430> ?p ?o ?g. }
- W2102935430 abstract "Gonadotropin-releasing hormone (GnRH) is a small neuropeptide of which there are multiple structural variants. The first variant identified in mammals, GnRH I, controls the release of pituitary gonadotropins. More recently, a second isoform, GnRH II, first isolated in the bird, was identified in the mammalian brain and periphery. Although it is unlikely to be a primary regulator of gonadotropin release, GnRH II appears to have a wide array of physiological and behavioral functions. GnRH II-containing fibers are present in several nuclei known to regulate reproduction and/or feeding, and its concentration in several of these areas fluctuates in response to changes in food availability, and thus energetic status. In musk shrews, GnRH II acts as a permissive regulator of female reproductive behavior based on energy status, as well as an inhibitor of short-term food intake. In this regard, GnRH II is similar to leptin, neuropeptide Y and several other neurotransmitters that regulate both feeding and reproduction. At least two GnRH receptors are present in the mammalian brain, and increasing evidence suggests that the behavioral effects of GnRH II are mediated by receptor subtypes distinct from the type-1 GnRH receptor (which mediates GnRH I action); the most probable candidate is the type-2 GnRH receptor. GnRH II also regulates the density and/or activity of calcium and potassium channels in the nervous systems of amphibians and fish, a function that may also exist in mammalian neurons. It is likely that the highly conserved GnRH II system has been co-opted over evolutionary time to possess multiple regulatory functions in a broad range of neurobiological aspects." @default.
- W2102935430 created "2016-06-24" @default.
- W2102935430 creator A5042566768 @default.
- W2102935430 creator A5091125715 @default.
- W2102935430 date "2006-01-01" @default.
- W2102935430 modified "2023-09-23" @default.
- W2102935430 title "Role of gonadotropin-releasing hormone II in the mammalian nervous system" @default.
- W2102935430 cites W1522995890 @default.
- W2102935430 cites W1545090210 @default.
- W2102935430 cites W1926158943 @default.
- W2102935430 cites W1949137771 @default.
- W2102935430 cites W1963686255 @default.
- W2102935430 cites W1964074947 @default.
- W2102935430 cites W1965903438 @default.
- W2102935430 cites W1968084526 @default.
- W2102935430 cites W1968899166 @default.
- W2102935430 cites W1972536915 @default.
- W2102935430 cites W1972715709 @default.
- W2102935430 cites W1976875374 @default.
- W2102935430 cites W1976947803 @default.
- W2102935430 cites W1978204901 @default.
- W2102935430 cites W1984978212 @default.
- W2102935430 cites W1985076880 @default.
- W2102935430 cites W1989652277 @default.
- W2102935430 cites W1990804226 @default.
- W2102935430 cites W1991577682 @default.
- W2102935430 cites W1994117869 @default.
- W2102935430 cites W1994775100 @default.
- W2102935430 cites W1995855023 @default.
- W2102935430 cites W1996275319 @default.
- W2102935430 cites W1999193579 @default.
- W2102935430 cites W1999266526 @default.
- W2102935430 cites W2002262665 @default.
- W2102935430 cites W2002788608 @default.
- W2102935430 cites W2003845868 @default.
- W2102935430 cites W2004485336 @default.
- W2102935430 cites W2005409839 @default.
- W2102935430 cites W2005752370 @default.
- W2102935430 cites W2006081278 @default.
- W2102935430 cites W2008109701 @default.
- W2102935430 cites W2008557047 @default.
- W2102935430 cites W2009126237 @default.
- W2102935430 cites W2011664306 @default.
- W2102935430 cites W2015994946 @default.
- W2102935430 cites W2018739526 @default.
- W2102935430 cites W2020055321 @default.
- W2102935430 cites W2020442036 @default.
- W2102935430 cites W2021354355 @default.
- W2102935430 cites W2032466162 @default.
- W2102935430 cites W2037753958 @default.
- W2102935430 cites W2039099840 @default.
- W2102935430 cites W2039198739 @default.
- W2102935430 cites W2039565165 @default.
- W2102935430 cites W2040927153 @default.
- W2102935430 cites W2042547360 @default.
- W2102935430 cites W2043136148 @default.
- W2102935430 cites W2044648944 @default.
- W2102935430 cites W2046938043 @default.
- W2102935430 cites W2047676270 @default.
- W2102935430 cites W2049223580 @default.
- W2102935430 cites W2050855898 @default.
- W2102935430 cites W2052768984 @default.
- W2102935430 cites W2054330449 @default.
- W2102935430 cites W2055060816 @default.
- W2102935430 cites W2056640259 @default.
- W2102935430 cites W2066654447 @default.
- W2102935430 cites W2066699994 @default.
- W2102935430 cites W2072629570 @default.
- W2102935430 cites W2074527323 @default.
- W2102935430 cites W2077654582 @default.
- W2102935430 cites W2079470975 @default.
- W2102935430 cites W2081163324 @default.
- W2102935430 cites W2081887471 @default.
- W2102935430 cites W2089670528 @default.
- W2102935430 cites W2089719946 @default.
- W2102935430 cites W2093500419 @default.
- W2102935430 cites W2099568965 @default.
- W2102935430 cites W2100196866 @default.
- W2102935430 cites W2116534252 @default.
- W2102935430 cites W2117797603 @default.
- W2102935430 cites W2121384928 @default.
- W2102935430 cites W2125221655 @default.
- W2102935430 cites W2126973348 @default.
- W2102935430 cites W2132672841 @default.
- W2102935430 cites W2132966314 @default.
- W2102935430 cites W2134027175 @default.
- W2102935430 cites W2135464933 @default.
- W2102935430 cites W2136920216 @default.
- W2102935430 cites W2139981662 @default.
- W2102935430 cites W2141582604 @default.
- W2102935430 cites W2149515083 @default.
- W2102935430 cites W2152988989 @default.
- W2102935430 cites W2156839821 @default.
- W2102935430 cites W2159239249 @default.
- W2102935430 cites W2167018410 @default.
- W2102935430 cites W2172180164 @default.
- W2102935430 cites W2329408966 @default.
- W2102935430 cites W2337364905 @default.
- W2102935430 cites W308382139 @default.
- W2102935430 cites W2024776674 @default.