FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102940020> ?p ?o ?g. }

• W2102940020 endingPage "142" @default.
• W2102940020 startingPage "133" @default.
• W2102940020 abstract "The relationship between gene dosage imbalance and phenotypes associated with Trisomy 21, including the etiology of abnormal bone phenotypes linked to Down syndrome (DS), is not well understood. The Ts65Dn mouse model for DS exhibits appendicular skeletal defects during adolescence and adulthood but the developmental and genetic origin of these phenotypes remains unclear. It is hypothesized that the postnatal Ts65Dn skeletal phenotype originates during embryonic development and results from an increased Dyrk1a gene copy number, a gene hypothesized to play a critical role in many DS phenotypes. Ts65Dn embryos exhibit a lower percent bone volume in the E17.5 femur when compared to euploid embryos. Concomitant with gene copy number, qPCR analysis revealed a ~1.5 fold increase in Dyrk1a transcript levels in the Ts65Dn E17.5 embryonic femur as compared to euploid. Returning Dyrk1a copy number to euploid levels in Ts65Dn, Dyrk1a+/− embryos did not correct the trisomic skeletal phenotype but did return Dyrk1a gene transcript levels to normal. The size and protein expression patterns of the cartilage template during embryonic bone development appear to be unaffected at E14.5 and E17.5 in trisomic embryos. Taken together, these data suggest that the dosage imbalance of genes other than Dyrk1a is involved in the development of the prenatal bone phenotype in Ts65Dn embryos." @default.
• W2102940020 created "2016-06-24" @default.
• W2102940020 creator A5001180699 @default.
• W2102940020 creator A5014139713 @default.
• W2102940020 creator A5046079414 @default.
• W2102940020 creator A5048871371 @default.
• W2102940020 creator A5061597020 @default.
• W2102940020 creator A5074631415 @default.
• W2102940020 date "2015-05-01" @default.
• W2102940020 modified "2023-10-18" @default.
• W2102940020 title "Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner" @default.
• W2102940020 cites W1974654434 @default.
• W2102940020 cites W1987512395 @default.
• W2102940020 cites W1987571337 @default.
• W2102940020 cites W1992995639 @default.
• W2102940020 cites W1998804314 @default.
• W2102940020 cites W2014157276 @default.
• W2102940020 cites W2025222033 @default.
• W2102940020 cites W2030002671 @default.
• W2102940020 cites W2030669013 @default.
• W2102940020 cites W2040114944 @default.
• W2102940020 cites W2042916026 @default.
• W2102940020 cites W2045356817 @default.
• W2102940020 cites W2059617293 @default.
• W2102940020 cites W2069494535 @default.
• W2102940020 cites W2071776717 @default.
• W2102940020 cites W2079860207 @default.
• W2102940020 cites W2084233122 @default.
• W2102940020 cites W2092247599 @default.
• W2102940020 cites W2096452264 @default.
• W2102940020 cites W2099999081 @default.
• W2102940020 cites W2100061591 @default.
• W2102940020 cites W2101705652 @default.
• W2102940020 cites W2108244474 @default.
• W2102940020 cites W2108456530 @default.
• W2102940020 cites W2111942361 @default.
• W2102940020 cites W2119719996 @default.
• W2102940020 cites W2125851351 @default.
• W2102940020 cites W2128527424 @default.
• W2102940020 cites W2128532993 @default.
• W2102940020 cites W2129736783 @default.
• W2102940020 cites W2141593169 @default.
• W2102940020 cites W2147154230 @default.
• W2102940020 cites W2150737519 @default.
• W2102940020 cites W2153266499 @default.
• W2102940020 cites W2169631945 @default.
• W2102940020 cites W2171583389 @default.
• W2102940020 cites W4243723058 @default.
• W2102940020 doi "https://doi.org/10.1016/j.mod.2014.12.004" @default.
• W2102940020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25556111" @default.
• W2102940020 hasPublicationYear "2015" @default.
• W2102940020 type Work @default.
• W2102940020 sameAs 2102940020 @default.
• W2102940020 citedByCount "16" @default.
• W2102940020 countsByYear W21029400202015 @default.
• W2102940020 countsByYear W21029400202016 @default.
• W2102940020 countsByYear W21029400202017 @default.
• W2102940020 countsByYear W21029400202020 @default.
• W2102940020 countsByYear W21029400202021 @default.
• W2102940020 countsByYear W21029400202022 @default.
• W2102940020 countsByYear W21029400202023 @default.
• W2102940020 crossrefType "journal-article" @default.
• W2102940020 hasAuthorship W2102940020A5001180699 @default.
• W2102940020 hasAuthorship W2102940020A5014139713 @default.
• W2102940020 hasAuthorship W2102940020A5046079414 @default.
• W2102940020 hasAuthorship W2102940020A5048871371 @default.
• W2102940020 hasAuthorship W2102940020A5061597020 @default.
• W2102940020 hasAuthorship W2102940020A5074631415 @default.
• W2102940020 hasBestOaLocation W21029400202 @default.
• W2102940020 hasConcept C104317684 @default.
• W2102940020 hasConcept C105702510 @default.
• W2102940020 hasConcept C127716648 @default.
• W2102940020 hasConcept C145103041 @default.
• W2102940020 hasConcept C150194340 @default.
• W2102940020 hasConcept C196843134 @default.
• W2102940020 hasConcept C2776229224 @default.
• W2102940020 hasConcept C2777736865 @default.
• W2102940020 hasConcept C2779954681 @default.
• W2102940020 hasConcept C2780359839 @default.
• W2102940020 hasConcept C2780707029 @default.
• W2102940020 hasConcept C54355233 @default.
• W2102940020 hasConcept C55548728 @default.
• W2102940020 hasConcept C86803240 @default.
• W2102940020 hasConcept C87073359 @default.
• W2102940020 hasConceptScore W2102940020C104317684 @default.
• W2102940020 hasConceptScore W2102940020C105702510 @default.
• W2102940020 hasConceptScore W2102940020C127716648 @default.
• W2102940020 hasConceptScore W2102940020C145103041 @default.
• W2102940020 hasConceptScore W2102940020C150194340 @default.
• W2102940020 hasConceptScore W2102940020C196843134 @default.
• W2102940020 hasConceptScore W2102940020C2776229224 @default.
• W2102940020 hasConceptScore W2102940020C2777736865 @default.
• W2102940020 hasConceptScore W2102940020C2779954681 @default.
• W2102940020 hasConceptScore W2102940020C2780359839 @default.
• W2102940020 hasConceptScore W2102940020C2780707029 @default.
• W2102940020 hasConceptScore W2102940020C54355233 @default.
• W2102940020 hasConceptScore W2102940020C55548728 @default.
• W2102940020 hasConceptScore W2102940020C86803240 @default.

• next