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- W2102947626 abstract "In a lethal West Nile virus (WNV) model, central nervous system infection triggered a threefold increase in CD45int/CD11b+/CD11c− microglia at days 6–7 postinfection (p.i.). Few microglia were proliferating, suggesting that the increased numbers were derived from a migratory precursor cell. Depletion of “circulating” (Gr1−(Ly6Clo)CX3CR1+) and “inflammatory” (Gr1hi/Ly6Chi/CCR2+) classical monocytes during infection abrogated the increase in microglia. C57BL/6 chimeras reconstituted with cFMS–enhanced green fluorescent protein (EGFP) bone marrow (BM) showed large numbers of peripherally derived (GFP+) microglia expressing GR1+(Ly6C+) at day 7 p.i., suggesting that the inflammatory monocyte is a microglial precursor. This was confirmed by adoptive transfer of labeled BM (Ly6Chi/CD115+) or circulating inflammatory monocytes that trafficked to the WNV-infected brain and expressed a microglial phenotype. CCL2 is a chemokine that is highly expressed during WNV infection and important in inflammatory monocyte trafficking. Neutralization of CCL2 not only reduced the number of GFP+ microglia in the brain during WNV infection but prolonged the life of infected animals. Therefore, CCL2-dependent inflammatory monocyte migration is critical for increases in microglia during WNV infection and may also play a pathogenic role during WNV encephalitis." @default.
- W2102947626 created "2016-06-24" @default.
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- W2102947626 date "2008-09-08" @default.
- W2102947626 modified "2023-10-18" @default.
- W2102947626 title "Ly6c+ “inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis" @default.
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- W2102947626 cites W1936737016 @default.
- W2102947626 cites W1956258286 @default.
- W2102947626 cites W1964937686 @default.
- W2102947626 cites W1967135759 @default.
- W2102947626 cites W1973891258 @default.
- W2102947626 cites W1975856293 @default.
- W2102947626 cites W1980478623 @default.
- W2102947626 cites W1980560678 @default.
- W2102947626 cites W1989547561 @default.
- W2102947626 cites W1990920498 @default.
- W2102947626 cites W1991805788 @default.
- W2102947626 cites W1993677761 @default.
- W2102947626 cites W1994600662 @default.
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- W2102947626 cites W2002432566 @default.
- W2102947626 cites W2004070471 @default.
- W2102947626 cites W2004737689 @default.
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- W2102947626 cites W2025019998 @default.
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- W2102947626 cites W2029906813 @default.
- W2102947626 cites W2033534662 @default.
- W2102947626 cites W2043976521 @default.
- W2102947626 cites W2049853374 @default.
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- W2102947626 cites W2078811876 @default.
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- W2102947626 cites W2145824031 @default.
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- W2102947626 doi "https://doi.org/10.1084/jem.20080421" @default.
- W2102947626 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2556789" @default.
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