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• W2102948520 abstract "Abstract Francisella tularensis (Ft) is a Gram-negative bacterium and the causative agent of tularemia. It is well established that this organism replicates inside macrophages, but we are only beginning to understand this interface at the molecular level. Herein, we compared directly the ability of Ft subspecies holarctica live-vaccine strain to infect freshly isolated human peripheral blood monocytes, monocyte-derived macrophages (MDM), and cells of the murine macrophage cell line J774A.1 (J774). We now show that unopsonized bacteria infected human MDM fivefold more efficiently than monocytes or J774 cells in standard media. Moreover, enhanced infection of MDM was mediated, in part, by te macrophage mannose receptor (MR). Forming Ft phagosomes accumulated MR, and infection was inhibited by MR-blocking antibody or soluble mannan but not by the dectin-1 ligand laminarin. Up-regulation of MR in MDM (by exposure to interleukin-4) increased Ft phagocytosis, as did expression of MR in J774 cells. Conversely, opsonized Ft were ingested readily by monocytes and MDM. Medium supplementation with 2.5% fresh autologous serum was sufficient to confer opsonophagocytosis and CD11b accumulated in the membrane at sites of Ft engulfment. Infection of monocytes by opsonized Ft was nearly ablated by complement receptor 3 (CR3) blockade. Conversely, MDM used MR and CD11b/CD18 to ingest opsonized organisms. Altogether, our data demonstrate differential infection of mononuclear phagocytes by Ft and define distinct roles for MR and CR3 in phagocytosis." @default.
• W2102948520 created "2016-06-24" @default.
• W2102948520 creator A5002868596 @default.
• W2102948520 creator A5052550075 @default.
• W2102948520 date "2006-06-30" @default.
• W2102948520 modified "2023-10-16" @default.
• W2102948520 title "Differential infection of mononuclear phagocytes by <i>Francisella tularensis</i>: role of the macrophage mannose receptor" @default.
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• W2102948520 doi "https://doi.org/10.1189/jlb.0306219" @default.
• W2102948520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1865506" @default.
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• W2102948520 hasPublicationYear "2006" @default.
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