FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102948810> ?p ?o ?g. }

• W2102948810 endingPage "5401" @default.
• W2102948810 startingPage "5390" @default.
• W2102948810 abstract "Cell adhesion molecules (CADM) comprise a newly identified protein family whose functions include cell polarity maintenance and tumor suppression. CADM-1, CADM-3, and CADM-4 have been shown to act as tumor suppressor genes in multiple cancers including prostate cancer. However, CADM-2 expression has not been determined in prostate cancer.The CADM-2 gene was cloned and characterized and its expression in human prostatic cell lines and cancer specimens was analyzed by reverse transcription-PCR and an immunohistochemical tissue array, respectively. The effects of adenovirus-mediated CADM-2 expression on prostate cancer cells were also investigated. CADM-2 promoter methylation was evaluated by bisulfite sequencing and methylation-specific PCR.We report the initial characterization of CADM-2 isoforms: CADM-2a and CADM-2b, each with separate promoters, in human chromosome 3p12.1. Prostate cancer cell lines, LNCaP and DU145, expressed negligible CADM-2a relative to primary prostate tissue and cell lines, RWPE-1 and PPC-1, whereas expression of CADM-2b was maintained. Using immunohistochemistry, tissue array results from clinical specimens showed statistically significant decreased expression in prostate carcinoma compared with normal donor prostate, benign prostatic hyperplasia, prostatic intraepithelial neoplasia, and normal tissue adjacent to tumor (P < 0.001). Adenovirus-mediated CADM-2a expression suppressed DU145 cell proliferation in vitro and colony formation in soft agar. The decrease in CADM-2a mRNA in cancer cell lines correlated with promoter region hypermethylation as determined by bisulfite sequencing and methylation-specific PCR. Accordingly, treatment of cells with the demethylating agent 5-aza-2'-deoxycytidine alone or in combination with the histone deacetylase inhibitor trichostatin A resulted in the reactivation of CADM-2a expression.CADM-2a protein expression is significantly reduced in prostate cancer. Its expression is regulated in part by promoter methylation and implicates CADM-2 as a previously unrecognized tumor suppressor gene in a proportion of human prostate cancers." @default.
• W2102948810 created "2016-06-24" @default.
• W2102948810 creator A5004781857 @default.
• W2102948810 creator A5025346098 @default.
• W2102948810 creator A5026903972 @default.
• W2102948810 creator A5040924182 @default.
• W2102948810 creator A5042053744 @default.
• W2102948810 creator A5042696980 @default.
• W2102948810 creator A5043779425 @default.
• W2102948810 date "2010-11-14" @default.
• W2102948810 modified "2023-10-08" @default.
• W2102948810 title "Hypoexpression and Epigenetic Regulation of Candidate Tumor Suppressor Gene <i>CADM-2</i> in Human Prostate Cancer" @default.
• W2102948810 cites W1533251376 @default.
• W2102948810 cites W1965214112 @default.
• W2102948810 cites W1972462355 @default.
• W2102948810 cites W1990331009 @default.
• W2102948810 cites W1990349961 @default.
• W2102948810 cites W1991138076 @default.
• W2102948810 cites W1996072637 @default.
• W2102948810 cites W2021383412 @default.
• W2102948810 cites W2028124085 @default.
• W2102948810 cites W2030771667 @default.
• W2102948810 cites W2033524514 @default.
• W2102948810 cites W2036946605 @default.
• W2102948810 cites W2045982021 @default.
• W2102948810 cites W2048452989 @default.
• W2102948810 cites W2051434331 @default.
• W2102948810 cites W2058126552 @default.
• W2102948810 cites W2067689492 @default.
• W2102948810 cites W2075115463 @default.
• W2102948810 cites W2083927933 @default.
• W2102948810 cites W2086994203 @default.
• W2102948810 cites W2088684637 @default.
• W2102948810 cites W2091206598 @default.
• W2102948810 cites W2101995865 @default.
• W2102948810 cites W2119176807 @default.
• W2102948810 cites W2122921023 @default.
• W2102948810 cites W2130919037 @default.
• W2102948810 cites W2139122477 @default.
• W2102948810 cites W2140949230 @default.
• W2102948810 cites W2148819836 @default.
• W2102948810 cites W2160779567 @default.
• W2102948810 cites W2163288644 @default.
• W2102948810 cites W2334564428 @default.
• W2102948810 cites W4253422011 @default.
• W2102948810 doi "https://doi.org/10.1158/1078-0432.ccr-10-1461" @default.
• W2102948810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3541035" @default.
• W2102948810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21062931" @default.
• W2102948810 hasPublicationYear "2010" @default.
• W2102948810 type Work @default.
• W2102948810 sameAs 2102948810 @default.
• W2102948810 citedByCount "35" @default.
• W2102948810 countsByYear W21029488102012 @default.
• W2102948810 countsByYear W21029488102013 @default.
• W2102948810 countsByYear W21029488102014 @default.
• W2102948810 countsByYear W21029488102015 @default.
• W2102948810 countsByYear W21029488102016 @default.
• W2102948810 countsByYear W21029488102017 @default.
• W2102948810 countsByYear W21029488102018 @default.
• W2102948810 countsByYear W21029488102019 @default.
• W2102948810 countsByYear W21029488102020 @default.
• W2102948810 countsByYear W21029488102021 @default.
• W2102948810 countsByYear W21029488102022 @default.
• W2102948810 countsByYear W21029488102023 @default.
• W2102948810 crossrefType "journal-article" @default.
• W2102948810 hasAuthorship W2102948810A5004781857 @default.
• W2102948810 hasAuthorship W2102948810A5025346098 @default.
• W2102948810 hasAuthorship W2102948810A5026903972 @default.
• W2102948810 hasAuthorship W2102948810A5040924182 @default.
• W2102948810 hasAuthorship W2102948810A5042053744 @default.
• W2102948810 hasAuthorship W2102948810A5042696980 @default.
• W2102948810 hasAuthorship W2102948810A5043779425 @default.
• W2102948810 hasBestOaLocation W21029488101 @default.
• W2102948810 hasConcept C104317684 @default.
• W2102948810 hasConcept C121608353 @default.
• W2102948810 hasConcept C150194340 @default.
• W2102948810 hasConcept C153911025 @default.
• W2102948810 hasConcept C189235521 @default.
• W2102948810 hasConcept C190727270 @default.
• W2102948810 hasConcept C2776235491 @default.
• W2102948810 hasConcept C2776438761 @default.
• W2102948810 hasConcept C2779723316 @default.
• W2102948810 hasConcept C2780192828 @default.
• W2102948810 hasConcept C33288867 @default.
• W2102948810 hasConcept C41091548 @default.
• W2102948810 hasConcept C502942594 @default.
• W2102948810 hasConcept C54355233 @default.
• W2102948810 hasConcept C86803240 @default.
• W2102948810 hasConcept C96232424 @default.
• W2102948810 hasConceptScore W2102948810C104317684 @default.
• W2102948810 hasConceptScore W2102948810C121608353 @default.
• W2102948810 hasConceptScore W2102948810C150194340 @default.
• W2102948810 hasConceptScore W2102948810C153911025 @default.
• W2102948810 hasConceptScore W2102948810C189235521 @default.
• W2102948810 hasConceptScore W2102948810C190727270 @default.
• W2102948810 hasConceptScore W2102948810C2776235491 @default.
• W2102948810 hasConceptScore W2102948810C2776438761 @default.
• W2102948810 hasConceptScore W2102948810C2779723316 @default.

• next