FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102956677> ?p ?o ?g. }

• W2102956677 endingPage "194" @default.
• W2102956677 startingPage "183" @default.
• W2102956677 abstract "The purpose of the present investigation was to determine the selectivity, specificity and kinetics of the androgen regulation of the ocular secretory immune system. To examine the mucosal selectivity of hormone action, tears, saliva, respiratory and intestinal secretions, urine and serum were collected from orchiectomized rats following four days of treatment with saline or testosterone. Androgen administration significantly increased the tear levels of IgA and free SC. In contrast, this combined hormone response was not duplicated in other mucosal secretions or serum. Consequently, it appears that the androgen control of the ocular secretory immune system is unique to the eye. To evaluate androgenic specificity, orchiectomized rats were treated for four days with saline, testosterone, 5 alpha-androstan-17 beta-o1 ('5 alpha'), 4-estren-7 alpha-methyl-17 beta-o1-3-one ('4-E') or the synthetic analogue, danazol. Results demonstrated that testosterone and '4-E', a potent androgen, both stimulated the accumulation of tear IgA and free SC, compared to amounts in tears of saline-treated controls. The weak androgen '5 alpha' induced a slight rise in tear free SC, but not IgA, levels, whereas danazol had no effect on the ocular secretory immune system. These findings indicate that androgen structure is of critical importance in modulation of mucosal immunity in the eye. Lastly, to assess the kinetics of hormone action on tear IgA and free SC, orchiectomized rats were acutely (0, 1.5, 4, 7, 12, or 24 hours) or chronically (0, 4, 7, 11, 14, or 17 days) exposed to testosterone. Acute androgen exposure for less than 12 hours did not elicit any change in the tear content of IgA or free SC. In comparison, chronic androgen treatment induced a progressive and dramatic rise in the levels of both tear proteins. By 17 days of hormone exposure, the IgA and free SC concentrations in tears had increased by 14- and 18-fold amounts, respectively, relative to amounts in placebo-treated controls. Of interest, the temporal pattern of accumulation of tear IgA and free SC were different. Overall, these results show prolonged, but not abbreviated, exposure to androgens has a profound impact on the IgA and free SC profile in tears." @default.
• W2102956677 created "2016-06-24" @default.
• W2102956677 creator A5022042534 @default.
• W2102956677 creator A5028478656 @default.
• W2102956677 creator A5084781940 @default.
• W2102956677 date "1988-01-01" @default.
• W2102956677 modified "2023-09-23" @default.
• W2102956677 title "Selectivity, Specificity and Kinetics of the Androgen Regulation of the Ocular Secretory Immune System" @default.
• W2102956677 cites W1986669114 @default.
• W2102956677 cites W1992165733 @default.
• W2102956677 cites W2004395480 @default.
• W2102956677 cites W2005923905 @default.
• W2102956677 cites W2014281089 @default.
• W2102956677 cites W2016782194 @default.
• W2102956677 cites W2016836146 @default.
• W2102956677 cites W2017701535 @default.
• W2102956677 cites W2021071650 @default.
• W2102956677 cites W2023047778 @default.
• W2102956677 cites W2032444384 @default.
• W2102956677 cites W2033693803 @default.
• W2102956677 cites W2041174923 @default.
• W2102956677 cites W2042207521 @default.
• W2102956677 cites W2048333450 @default.
• W2102956677 cites W2057211216 @default.
• W2102956677 cites W2074923888 @default.
• W2102956677 cites W2079772188 @default.
• W2102956677 cites W2081208790 @default.
• W2102956677 cites W2087610426 @default.
• W2102956677 cites W2090946351 @default.
• W2102956677 cites W2102960640 @default.
• W2102956677 cites W2113276215 @default.
• W2102956677 cites W2126210741 @default.
• W2102956677 cites W2143682524 @default.
• W2102956677 cites W2323757417 @default.
• W2102956677 cites W2409283123 @default.
• W2102956677 cites W2429439337 @default.
• W2102956677 cites W2898050329 @default.
• W2102956677 cites W4243319290 @default.
• W2102956677 doi "https://doi.org/10.3109/08820138809052959" @default.
• W2102956677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3410512" @default.
• W2102956677 hasPublicationYear "1988" @default.
• W2102956677 type Work @default.
• W2102956677 sameAs 2102956677 @default.
• W2102956677 citedByCount "22" @default.
• W2102956677 countsByYear W21029566772012 @default.
• W2102956677 countsByYear W21029566772014 @default.
• W2102956677 countsByYear W21029566772017 @default.
• W2102956677 countsByYear W21029566772018 @default.
• W2102956677 countsByYear W21029566772020 @default.
• W2102956677 crossrefType "journal-article" @default.
• W2102956677 hasAuthorship W2102956677A5022042534 @default.
• W2102956677 hasAuthorship W2102956677A5028478656 @default.
• W2102956677 hasAuthorship W2102956677A5084781940 @default.
• W2102956677 hasConcept C126322002 @default.
• W2102956677 hasConcept C134018914 @default.
• W2102956677 hasConcept C203014093 @default.
• W2102956677 hasConcept C2777416354 @default.
• W2102956677 hasConcept C2777911890 @default.
• W2102956677 hasConcept C2778275304 @default.
• W2102956677 hasConcept C2779279991 @default.
• W2102956677 hasConcept C2779522080 @default.
• W2102956677 hasConcept C504460877 @default.
• W2102956677 hasConcept C71315377 @default.
• W2102956677 hasConcept C71924100 @default.
• W2102956677 hasConcept C86803240 @default.
• W2102956677 hasConcept C8891405 @default.
• W2102956677 hasConceptScore W2102956677C126322002 @default.
• W2102956677 hasConceptScore W2102956677C134018914 @default.
• W2102956677 hasConceptScore W2102956677C203014093 @default.
• W2102956677 hasConceptScore W2102956677C2777416354 @default.
• W2102956677 hasConceptScore W2102956677C2777911890 @default.
• W2102956677 hasConceptScore W2102956677C2778275304 @default.
• W2102956677 hasConceptScore W2102956677C2779279991 @default.
• W2102956677 hasConceptScore W2102956677C2779522080 @default.
• W2102956677 hasConceptScore W2102956677C504460877 @default.
• W2102956677 hasConceptScore W2102956677C71315377 @default.
• W2102956677 hasConceptScore W2102956677C71924100 @default.
• W2102956677 hasConceptScore W2102956677C86803240 @default.
• W2102956677 hasConceptScore W2102956677C8891405 @default.
• W2102956677 hasIssue "3" @default.
• W2102956677 hasLocation W21029566771 @default.
• W2102956677 hasLocation W21029566772 @default.
• W2102956677 hasOpenAccess W2102956677 @default.
• W2102956677 hasPrimaryLocation W21029566771 @default.
• W2102956677 hasRelatedWork W125221846 @default.
• W2102956677 hasRelatedWork W1968981366 @default.
• W2102956677 hasRelatedWork W1995975940 @default.
• W2102956677 hasRelatedWork W2005718116 @default.
• W2102956677 hasRelatedWork W2030295611 @default.
• W2102956677 hasRelatedWork W2117783268 @default.
• W2102956677 hasRelatedWork W2119950598 @default.
• W2102956677 hasRelatedWork W2385177222 @default.
• W2102956677 hasRelatedWork W64865263 @default.
• W2102956677 hasRelatedWork W2252288996 @default.
• W2102956677 hasVolume "17" @default.
• W2102956677 isParatext "false" @default.
• W2102956677 isRetracted "false" @default.
• W2102956677 magId "2102956677" @default.

• next