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- W2102959241 abstract "Background: Succinobucol (AGI-1067) was developed as a probucol derivative with anti-inflammatory and antioxidant properties. It has undergone Phase III clinical trials to determine its place in the treatment of atherosclerotic disease. Objective: This paper reviews the available history, pharmacology and preclinical and clinical trial data of succinobucol. Methods: Data were compiled following review of publications indexed in Medline and International Pharmaceutical Abstracts, industry media releases and relevant bibliographies. Results/conclusion: In preclinical studies, succinobucol exhibited antioxidant, anti-inflammatory, antihyperglycemic and antiplatelet properties; however, these effects have not resulted in a reduction in cardiovascular clinical end points in clinical trials. Although proposed antihyperglycemic effects are being investigated, safety concerns and lack of clear cardiovascular benefit may limit its clinical use as an antihyperglycemic agent." @default.
- W2102959241 created "2016-06-24" @default.
- W2102959241 creator A5047603210 @default.
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- W2102959241 date "2009-04-01" @default.
- W2102959241 modified "2023-10-15" @default.
- W2102959241 title "Succinobucol: review of the metabolic, antiplatelet and cardiovascular effects" @default.
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- W2102959241 doi "https://doi.org/10.1517/13543780902849244" @default.
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