FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102973281> ?p ?o ?g. }

• W2102973281 endingPage "9" @default.
• W2102973281 startingPage "1" @default.
• W2102973281 abstract "Flemingia macrophylla (Leguminosae) is a popular traditional remedy used in Taiwan as anti-inflammatory, promoting blood circulation and antidiabetes agent. Recent study also suggested its neuroprotective activity against Alzheimer's disease. Therefore, the effects of F. macrophylla on Aβ production and degradation were studied. The effect of F. macrophylla on Aβ metabolism was detected using the cultured mouse neuroblastoma cells N2a transfected with human Swedish mutant APP (swAPP-N2a cells). The effects on Aβ degradation were evaluated on a cell-free system. An ELISA assay was applied to detect the level of Aβ1-40 and Aβ1-42. Western blots assay was employed to measure the levels of soluble amyloid precursor protein and insulin degrading enzyme (IDE). Three fractions of F. macrophylla modified Aβ accumulation by both inhibiting β-secretase and activating IDE. Three flavonoids modified Aβ accumulation by activating IDE. The activated IDE pool by the flavonoids was distinctly regulated by bacitracin (an IDE inhibitor). Furthermore, flavonoid 94-18-13 also modulates Aβ accumulation by enhancing IDE expression. In conclusion, the components of F. macrophylla possess the potential for developing new therapeutic drugs for Alzheimer's disease." @default.
• W2102973281 created "2016-06-24" @default.
• W2102973281 creator A5007826292 @default.
• W2102973281 creator A5018960518 @default.
• W2102973281 creator A5021052863 @default.
• W2102973281 creator A5037706185 @default.
• W2102973281 creator A5071111555 @default.
• W2102973281 creator A5081341048 @default.
• W2102973281 date "2012-01-01" @default.
• W2102973281 modified "2023-10-10" @default.
• W2102973281 title "The Components of<i>Flemingia macrophylla</i>Attenuate Amyloid<i>β</i>-Protein Accumulation by Regulating Amyloid<i>β</i>-Protein Metabolic Pathway" @default.
• W2102973281 cites W1543737421 @default.
• W2102973281 cites W1642388756 @default.
• W2102973281 cites W1729585270 @default.
• W2102973281 cites W196680064 @default.
• W2102973281 cites W1970362533 @default.
• W2102973281 cites W1971922123 @default.
• W2102973281 cites W1984567402 @default.
• W2102973281 cites W1988531009 @default.
• W2102973281 cites W1990055868 @default.
• W2102973281 cites W1994554610 @default.
• W2102973281 cites W2000742404 @default.
• W2102973281 cites W2005481412 @default.
• W2102973281 cites W2009468295 @default.
• W2102973281 cites W2024977010 @default.
• W2102973281 cites W2029427029 @default.
• W2102973281 cites W2032694200 @default.
• W2102973281 cites W2038663652 @default.
• W2102973281 cites W2044511110 @default.
• W2102973281 cites W2045294258 @default.
• W2102973281 cites W2047304481 @default.
• W2102973281 cites W2056461294 @default.
• W2102973281 cites W2060851420 @default.
• W2102973281 cites W2061964324 @default.
• W2102973281 cites W2063038722 @default.
• W2102973281 cites W2063699848 @default.
• W2102973281 cites W2067089466 @default.
• W2102973281 cites W2068781633 @default.
• W2102973281 cites W2069528345 @default.
• W2102973281 cites W2076517751 @default.
• W2102973281 cites W2078229203 @default.
• W2102973281 cites W2080274663 @default.
• W2102973281 cites W2108850637 @default.
• W2102973281 cites W2123024190 @default.
• W2102973281 cites W2129659920 @default.
• W2102973281 cites W2130814643 @default.
• W2102973281 cites W2131570638 @default.
• W2102973281 cites W2133700043 @default.
• W2102973281 cites W2142496619 @default.
• W2102973281 cites W2147268537 @default.
• W2102973281 cites W2148017536 @default.
• W2102973281 cites W2149369886 @default.
• W2102973281 cites W2165496339 @default.
• W2102973281 cites W4237987670 @default.
• W2102973281 doi "https://doi.org/10.1155/2012/795843" @default.
• W2102973281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3376484" @default.
• W2102973281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22719789" @default.
• W2102973281 hasPublicationYear "2012" @default.
• W2102973281 type Work @default.
• W2102973281 sameAs 2102973281 @default.
• W2102973281 citedByCount "4" @default.
• W2102973281 countsByYear W21029732812015 @default.
• W2102973281 countsByYear W21029732812016 @default.
• W2102973281 countsByYear W21029732812019 @default.
• W2102973281 countsByYear W21029732812022 @default.
• W2102973281 crossrefType "journal-article" @default.
• W2102973281 hasAuthorship W2102973281A5007826292 @default.
• W2102973281 hasAuthorship W2102973281A5018960518 @default.
• W2102973281 hasAuthorship W2102973281A5021052863 @default.
• W2102973281 hasAuthorship W2102973281A5037706185 @default.
• W2102973281 hasAuthorship W2102973281A5071111555 @default.
• W2102973281 hasAuthorship W2102973281A5081341048 @default.
• W2102973281 hasBestOaLocation W21029732811 @default.
• W2102973281 hasConcept C104317684 @default.
• W2102973281 hasConcept C126322002 @default.
• W2102973281 hasConcept C179104552 @default.
• W2102973281 hasConcept C181199279 @default.
• W2102973281 hasConcept C185592680 @default.
• W2102973281 hasConcept C25498285 @default.
• W2102973281 hasConcept C2776415932 @default.
• W2102973281 hasConcept C2777633098 @default.
• W2102973281 hasConcept C2778004101 @default.
• W2102973281 hasConcept C2778171954 @default.
• W2102973281 hasConcept C2779054382 @default.
• W2102973281 hasConcept C2779134260 @default.
• W2102973281 hasConcept C2780331951 @default.
• W2102973281 hasConcept C31705614 @default.
• W2102973281 hasConcept C502032728 @default.
• W2102973281 hasConcept C55493867 @default.
• W2102973281 hasConcept C71924100 @default.
• W2102973281 hasConcept C86803240 @default.
• W2102973281 hasConcept C98274493 @default.
• W2102973281 hasConceptScore W2102973281C104317684 @default.
• W2102973281 hasConceptScore W2102973281C126322002 @default.
• W2102973281 hasConceptScore W2102973281C179104552 @default.
• W2102973281 hasConceptScore W2102973281C181199279 @default.
• W2102973281 hasConceptScore W2102973281C185592680 @default.
• W2102973281 hasConceptScore W2102973281C25498285 @default.

• next