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- W2103000719 abstract "The authors investigated the PRNP Met129Val polymorphism in 1,393 subjects including 482 patients with Alzheimer disease (AD) and two independent control groups. In patients, PRNP Met homozygosity conferred increasing risk with decreasing age at onset (onset: 61 to 70 years, n = 151, p = 0.02, odds ratio [OR] = 1.72, 95% CI = 1.2 to 2.53; onset: < or =60 years, n = 138, p = 0.013, OR = 1.92, 95% CI = 1.31 to 2.87), whereas no association was obtained in patients with onset at older than 70 years. The results suggest involvement of the prion protein in the pathogenesis of early-onset AD." @default.
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- W2103000719 date "2004-07-26" @default.
- W2103000719 modified "2023-10-16" @default.
- W2103000719 title "Prion protein codon 129 polymorphism and risk of Alzheimer disease" @default.
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- W2103000719 doi "https://doi.org/10.1212/01.wnl.0000130198.72589.69" @default.
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