FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103006502> ?p ?o ?g. }

• W2103006502 endingPage "78" @default.
• W2103006502 startingPage "60" @default.
• W2103006502 abstract "Lethal mutagenesis is an antiviral strategy that aims to extinguish viruses as a consequence of enhanced mutation rates during virus replication. The molecular mechanisms that underlie virus extinction by mutagenic nucleoside analogues are not well understood. When mutagenic agents and antiviral inhibitors are administered sequentially or in combination, interconnected and often conflicting selective constraints can influence the fate of the virus either towards survival through selection of mutagen-escape or inhibitor-escape mutants or towards extinction. Here we report a study involving the mutagenesis of foot-and-mouth disease virus (FMDV) by the nucleoside analogue ribavirin (R) and the effect of R-mediated mutagenesis on the selection of FMDV mutants resistant to the inhibitor of RNA replication, guanidine hydrochloride (GU). The results show that under comparable (and low) viral load, an inhibitory activity by GU could not substitute for an equivalent inhibitory activity by R in driving FMDV to extinction. Both the prior history of R mutagenesis and the viral population size influenced the selection of GU-escape mutants. A sufficiently low viral load allowed continued viral replication without selection of inhibitor-escape mutants, irrespective of the history of mutagenesis. These observations imply that reductions of viral load as a result of a mutagenic treatment may provide an opportunity either for immune-mediated clearing of a virus or for an alternative antiviral intervention, even if extinction is not initially achieved." @default.
• W2103006502 created "2016-06-24" @default.
• W2103006502 creator A5010609839 @default.
• W2103006502 creator A5035783315 @default.
• W2103006502 creator A5065031918 @default.
• W2103006502 creator A5068591898 @default.
• W2103006502 date "2011-03-01" @default.
• W2103006502 modified "2023-10-14" @default.
• W2103006502 title "Influence of Mutagenesis and Viral Load on the Sustained Low-Level Replication of an RNA Virus" @default.
• W2103006502 cites W100710130 @default.
• W2103006502 cites W118960938 @default.
• W2103006502 cites W150025772 @default.
• W2103006502 cites W1515293536 @default.
• W2103006502 cites W1526377546 @default.
• W2103006502 cites W1553547362 @default.
• W2103006502 cites W163268065 @default.
• W2103006502 cites W1848002574 @default.
• W2103006502 cites W1857653616 @default.
• W2103006502 cites W1894469212 @default.
• W2103006502 cites W1964549964 @default.
• W2103006502 cites W1969708447 @default.
• W2103006502 cites W1973635629 @default.
• W2103006502 cites W1974431527 @default.
• W2103006502 cites W1974484952 @default.
• W2103006502 cites W1974937764 @default.
• W2103006502 cites W1975106131 @default.
• W2103006502 cites W1977745444 @default.
• W2103006502 cites W1978500829 @default.
• W2103006502 cites W1978594581 @default.
• W2103006502 cites W1980167367 @default.
• W2103006502 cites W1981105411 @default.
• W2103006502 cites W1983134928 @default.
• W2103006502 cites W1994278598 @default.
• W2103006502 cites W1994304891 @default.
• W2103006502 cites W1994342377 @default.
• W2103006502 cites W1994399200 @default.
• W2103006502 cites W1995380235 @default.
• W2103006502 cites W1996242019 @default.
• W2103006502 cites W1996459980 @default.
• W2103006502 cites W2003574450 @default.
• W2103006502 cites W2005141763 @default.
• W2103006502 cites W2005299266 @default.
• W2103006502 cites W2009237550 @default.
• W2103006502 cites W2010063387 @default.
• W2103006502 cites W2012457782 @default.
• W2103006502 cites W2015216410 @default.
• W2103006502 cites W2018551422 @default.
• W2103006502 cites W2025634036 @default.
• W2103006502 cites W2027868702 @default.
• W2103006502 cites W2028114001 @default.
• W2103006502 cites W2028731897 @default.
• W2103006502 cites W2030121089 @default.
• W2103006502 cites W2032028701 @default.
• W2103006502 cites W2035551330 @default.
• W2103006502 cites W2036465650 @default.
• W2103006502 cites W2036711150 @default.
• W2103006502 cites W2037212056 @default.
• W2103006502 cites W2039472280 @default.
• W2103006502 cites W2040139732 @default.
• W2103006502 cites W2040722089 @default.
• W2103006502 cites W2045633232 @default.
• W2103006502 cites W2045919763 @default.
• W2103006502 cites W2046849818 @default.
• W2103006502 cites W2047976861 @default.
• W2103006502 cites W2050524167 @default.
• W2103006502 cites W2056044636 @default.
• W2103006502 cites W2060735144 @default.
• W2103006502 cites W2065897904 @default.
• W2103006502 cites W2068634302 @default.
• W2103006502 cites W2073863510 @default.
• W2103006502 cites W2074517161 @default.
• W2103006502 cites W2081130749 @default.
• W2103006502 cites W2081707536 @default.
• W2103006502 cites W2082165406 @default.
• W2103006502 cites W2089827667 @default.
• W2103006502 cites W2090388278 @default.
• W2103006502 cites W2090653286 @default.
• W2103006502 cites W2092058238 @default.
• W2103006502 cites W2094986548 @default.
• W2103006502 cites W2095568450 @default.
• W2103006502 cites W2096286859 @default.
• W2103006502 cites W2096519756 @default.
• W2103006502 cites W2103128451 @default.
• W2103006502 cites W2108123528 @default.
• W2103006502 cites W2113136473 @default.
• W2103006502 cites W2114430694 @default.
• W2103006502 cites W2114870795 @default.
• W2103006502 cites W2116597211 @default.
• W2103006502 cites W2117302214 @default.
• W2103006502 cites W2117601660 @default.
• W2103006502 cites W2117873191 @default.
• W2103006502 cites W2119238095 @default.
• W2103006502 cites W2124364050 @default.
• W2103006502 cites W2124692557 @default.
• W2103006502 cites W2125775699 @default.
• W2103006502 cites W2125923988 @default.
• W2103006502 cites W2126222710 @default.
• W2103006502 cites W2126589642 @default.

• next