Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103011674> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2103011674 endingPage "1025" @default.
- W2103011674 startingPage "1017" @default.
- W2103011674 abstract "The present study examined how daily treatment with the benzodiazepine (BZ) diazepam modifies the effects of positive modulators acting at different sites on the gamma-aminobutyric acid(A) (GABA(A)) receptor complex and negative modulators acting at BZ sites on the receptor complex. GABA(A) modulators were administered alone or in combination with acute or chronic diazepam to rhesus monkeys (n = 4) responding under a multiple fixed ratio (FR/FR) schedule of food presentation and stimulus-shock termination (SST). There was mutual antagonism between the rate-decreasing effects of diazepam (5.6 mg/kg, p.o.) and high efficacy BZ site negative modulators [ethyl beta-carboline-3-carboxylate (beta-CCE), methyl beta-carboline-3-carboxylate (beta-CCM) and methyl-6,7-dimethoxyl-4-ethyl-beta-carboline-3-carboxylate (DMCM)]. Antagonism of beta-CCE, beta-CCM, and DMCM by diazepam was markedly reduced in monkeys receiving diazepam daily. In contrast, daily diazepam treatment enhanced the rate-decreasing effects of Ro 15-4513 (ethyl 8-azido-6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-alpha]-[1,4]benzodiazepine-3-carboxylate) and flumazenil. Chronic diazepam elicited cross-tolerance to the BZ triazolam and not to the barbiturate pentobarbital or the neuroactive steroid pregnanolone. These results suggest that tolerance to the rate-decreasing effects of BZs is not accompanied by cross-tolerance to positive GABA(A) modulators acting at other sites on the receptor complex. Moreover, changes in sensitivity to negative GABA(A) modulators during chronic diazepam treatment appeared to be related to negative efficacy and not clearly related to the precipitation of withdrawal for all drugs. These results indicate that changes in sensitivity to the behavioral effects of drugs that act at different sites on the GABA(A) receptor complex might be especially useful for identifying and characterizing the functional consequences of GABA(A) receptor heterogeneity." @default.
- W2103011674 created "2016-06-24" @default.
- W2103011674 creator A5072276681 @default.
- W2103011674 date "2002-03-01" @default.
- W2103011674 modified "2023-10-14" @default.
- W2103011674 title "Daily Treatment with Diazepam Differentially Modifies Sensitivity to the Effects of γ-Aminobutyric Acid<sub>A</sub> Modulators on Schedule-Controlled Responding in Rhesus Monkeys" @default.
- W2103011674 cites W1673961606 @default.
- W2103011674 cites W1972421306 @default.
- W2103011674 cites W1983621709 @default.
- W2103011674 cites W1986624094 @default.
- W2103011674 cites W1988045452 @default.
- W2103011674 cites W1998392378 @default.
- W2103011674 cites W2014017755 @default.
- W2103011674 cites W2014556722 @default.
- W2103011674 cites W2017659544 @default.
- W2103011674 cites W2024168833 @default.
- W2103011674 cites W2027254751 @default.
- W2103011674 cites W2028650350 @default.
- W2103011674 cites W2029415612 @default.
- W2103011674 cites W2030656484 @default.
- W2103011674 cites W2047080686 @default.
- W2103011674 cites W2047654207 @default.
- W2103011674 cites W2048706813 @default.
- W2103011674 cites W2055250889 @default.
- W2103011674 cites W2061763682 @default.
- W2103011674 cites W2077378517 @default.
- W2103011674 cites W2079243571 @default.
- W2103011674 cites W2087145804 @default.
- W2103011674 cites W2100738202 @default.
- W2103011674 cites W2145845873 @default.
- W2103011674 cites W2147612834 @default.
- W2103011674 cites W2102189996 @default.
- W2103011674 doi "https://doi.org/10.1124/jpet.300.3.1017" @default.
- W2103011674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11861811" @default.
- W2103011674 hasPublicationYear "2002" @default.
- W2103011674 type Work @default.
- W2103011674 sameAs 2103011674 @default.
- W2103011674 citedByCount "19" @default.
- W2103011674 countsByYear W21030116742012 @default.
- W2103011674 countsByYear W21030116742013 @default.
- W2103011674 countsByYear W21030116742014 @default.
- W2103011674 crossrefType "journal-article" @default.
- W2103011674 hasAuthorship W2103011674A5072276681 @default.
- W2103011674 hasConcept C126322002 @default.
- W2103011674 hasConcept C134018914 @default.
- W2103011674 hasConcept C168258287 @default.
- W2103011674 hasConcept C170493617 @default.
- W2103011674 hasConcept C185592680 @default.
- W2103011674 hasConcept C2776175493 @default.
- W2103011674 hasConcept C2776801781 @default.
- W2103011674 hasConcept C2777383412 @default.
- W2103011674 hasConcept C2778173252 @default.
- W2103011674 hasConcept C2778409475 @default.
- W2103011674 hasConcept C2779738154 @default.
- W2103011674 hasConcept C2780077838 @default.
- W2103011674 hasConcept C44796713 @default.
- W2103011674 hasConcept C55493867 @default.
- W2103011674 hasConcept C71924100 @default.
- W2103011674 hasConcept C98274493 @default.
- W2103011674 hasConceptScore W2103011674C126322002 @default.
- W2103011674 hasConceptScore W2103011674C134018914 @default.
- W2103011674 hasConceptScore W2103011674C168258287 @default.
- W2103011674 hasConceptScore W2103011674C170493617 @default.
- W2103011674 hasConceptScore W2103011674C185592680 @default.
- W2103011674 hasConceptScore W2103011674C2776175493 @default.
- W2103011674 hasConceptScore W2103011674C2776801781 @default.
- W2103011674 hasConceptScore W2103011674C2777383412 @default.
- W2103011674 hasConceptScore W2103011674C2778173252 @default.
- W2103011674 hasConceptScore W2103011674C2778409475 @default.
- W2103011674 hasConceptScore W2103011674C2779738154 @default.
- W2103011674 hasConceptScore W2103011674C2780077838 @default.
- W2103011674 hasConceptScore W2103011674C44796713 @default.
- W2103011674 hasConceptScore W2103011674C55493867 @default.
- W2103011674 hasConceptScore W2103011674C71924100 @default.
- W2103011674 hasConceptScore W2103011674C98274493 @default.
- W2103011674 hasIssue "3" @default.
- W2103011674 hasLocation W21030116741 @default.
- W2103011674 hasLocation W21030116742 @default.
- W2103011674 hasOpenAccess W2103011674 @default.
- W2103011674 hasPrimaryLocation W21030116741 @default.
- W2103011674 hasRelatedWork W2021217579 @default.
- W2103011674 hasRelatedWork W2030617245 @default.
- W2103011674 hasRelatedWork W2045233123 @default.
- W2103011674 hasRelatedWork W2062211336 @default.
- W2103011674 hasRelatedWork W2069507134 @default.
- W2103011674 hasRelatedWork W2089212659 @default.
- W2103011674 hasRelatedWork W2128578499 @default.
- W2103011674 hasRelatedWork W2151685603 @default.
- W2103011674 hasRelatedWork W2262193049 @default.
- W2103011674 hasRelatedWork W4378745286 @default.
- W2103011674 hasVolume "300" @default.
- W2103011674 isParatext "false" @default.
- W2103011674 isRetracted "false" @default.
- W2103011674 magId "2103011674" @default.
- W2103011674 workType "article" @default.