FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103018035> ?p ?o ?g. }

• W2103018035 endingPage "6176" @default.
• W2103018035 startingPage "6169" @default.
• W2103018035 abstract "Abstract The identification of many tumor-associated epitopes as nonmutated “self” Ags led to the hypothesis that the induction of large numbers of self/tumor Ag-specific T cells would be prevented because of central and peripheral tolerance. We report in this study on vaccination efforts in 95 HLA-A*0201 patients at high risk for recurrence of malignant melanoma who received prolonged immunization with the “anchor-modified” synthetic peptide, gp100209–217(210M). Vaccination using this altered peptide immunogen was highly effective at inducing large numbers of self/tumor-Ag reactive T cells in virtually every patient tested, with levels as high as 42% of all CD8+ T cells assessed by tetramer analysis. From 1 to 10% of all CD8+ cells were tumor-Ag reactive in 44% of patients and levels &gt;10% were generated in 17% of patients. These studies were substantiated using the ELISPOT assay and a bulk cytokine release assay. Although our data regarding “tumor escape” were inconclusive, some patients had growing tumors that expressed Ag and HLA-A*0201 in the presence of high levels of antitumor T cells. There was no difference in the levels of antitumor Ag-specific T cells in patients who recurred compared with those that remained disease-free. Thus, the mere presence of profoundly expanded numbers of vaccine-induced, self/tumor Ag-specific T cells cannot by themselves be used as a “surrogate marker” for vaccine efficacy. Further, the induction of even high levels of antitumor T cells may be insufficient to alter tumor progression." @default.
• W2103018035 created "2016-06-24" @default.
• W2103018035 creator A5000470144 @default.
• W2103018035 creator A5006079020 @default.
• W2103018035 creator A5010906178 @default.
• W2103018035 creator A5024796100 @default.
• W2103018035 creator A5033167690 @default.
• W2103018035 creator A5043985374 @default.
• W2103018035 creator A5044239219 @default.
• W2103018035 creator A5052664794 @default.
• W2103018035 creator A5052962058 @default.
• W2103018035 creator A5052980036 @default.
• W2103018035 creator A5059747639 @default.
• W2103018035 creator A5065095849 @default.
• W2103018035 creator A5069061147 @default.
• W2103018035 creator A5071835245 @default.
• W2103018035 creator A5072133376 @default.
• W2103018035 creator A5085899790 @default.
• W2103018035 creator A5088790279 @default.
• W2103018035 date "2005-11-01" @default.
• W2103018035 modified "2023-10-16" @default.
• W2103018035 title "Tumor Progression Can Occur despite the Induction of Very High Levels of Self/Tumor Antigen-Specific CD8+ T Cells in Patients with Melanoma" @default.
• W2103018035 cites W1922646908 @default.
• W2103018035 cites W1928212615 @default.
• W2103018035 cites W1939839386 @default.
• W2103018035 cites W1960833366 @default.
• W2103018035 cites W1966813543 @default.
• W2103018035 cites W1983806918 @default.
• W2103018035 cites W1992699637 @default.
• W2103018035 cites W1996551232 @default.
• W2103018035 cites W2009402217 @default.
• W2103018035 cites W2014865000 @default.
• W2103018035 cites W2014949890 @default.
• W2103018035 cites W2051940153 @default.
• W2103018035 cites W2065648686 @default.
• W2103018035 cites W2076534279 @default.
• W2103018035 cites W2076730875 @default.
• W2103018035 cites W2079366194 @default.
• W2103018035 cites W2098574945 @default.
• W2103018035 cites W2098772563 @default.
• W2103018035 cites W2101363646 @default.
• W2103018035 cites W2104277030 @default.
• W2103018035 cites W2117289217 @default.
• W2103018035 cites W2124667997 @default.
• W2103018035 cites W2134638467 @default.
• W2103018035 cites W2142190430 @default.
• W2103018035 cites W2148523692 @default.
• W2103018035 cites W2159907225 @default.
• W2103018035 cites W2171342498 @default.
• W2103018035 cites W2269774696 @default.
• W2103018035 cites W3193387488 @default.
• W2103018035 cites W4230821365 @default.
• W2103018035 doi "https://doi.org/10.4049/jimmunol.175.9.6169" @default.
• W2103018035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1458368" @default.
• W2103018035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16585536" @default.
• W2103018035 hasPublicationYear "2005" @default.
• W2103018035 type Work @default.
• W2103018035 sameAs 2103018035 @default.
• W2103018035 citedByCount "435" @default.
• W2103018035 countsByYear W21030180352012 @default.
• W2103018035 countsByYear W21030180352013 @default.
• W2103018035 countsByYear W21030180352014 @default.
• W2103018035 countsByYear W21030180352015 @default.
• W2103018035 countsByYear W21030180352016 @default.
• W2103018035 countsByYear W21030180352017 @default.
• W2103018035 countsByYear W21030180352018 @default.
• W2103018035 countsByYear W21030180352019 @default.
• W2103018035 countsByYear W21030180352020 @default.
• W2103018035 countsByYear W21030180352021 @default.
• W2103018035 countsByYear W21030180352022 @default.
• W2103018035 countsByYear W21030180352023 @default.
• W2103018035 crossrefType "journal-article" @default.
• W2103018035 hasAuthorship W2103018035A5000470144 @default.
• W2103018035 hasAuthorship W2103018035A5006079020 @default.
• W2103018035 hasAuthorship W2103018035A5010906178 @default.
• W2103018035 hasAuthorship W2103018035A5024796100 @default.
• W2103018035 hasAuthorship W2103018035A5033167690 @default.
• W2103018035 hasAuthorship W2103018035A5043985374 @default.
• W2103018035 hasAuthorship W2103018035A5044239219 @default.
• W2103018035 hasAuthorship W2103018035A5052664794 @default.
• W2103018035 hasAuthorship W2103018035A5052962058 @default.
• W2103018035 hasAuthorship W2103018035A5052980036 @default.
• W2103018035 hasAuthorship W2103018035A5059747639 @default.
• W2103018035 hasAuthorship W2103018035A5065095849 @default.
• W2103018035 hasAuthorship W2103018035A5069061147 @default.
• W2103018035 hasAuthorship W2103018035A5071835245 @default.
• W2103018035 hasAuthorship W2103018035A5072133376 @default.
• W2103018035 hasAuthorship W2103018035A5085899790 @default.
• W2103018035 hasAuthorship W2103018035A5088790279 @default.
• W2103018035 hasBestOaLocation W21030180351 @default.
• W2103018035 hasConcept C147483822 @default.
• W2103018035 hasConcept C154317977 @default.
• W2103018035 hasConcept C159654299 @default.
• W2103018035 hasConcept C167672396 @default.
• W2103018035 hasConcept C195616568 @default.
• W2103018035 hasConcept C202751555 @default.
• W2103018035 hasConcept C203014093 @default.
• W2103018035 hasConcept C2776662205 @default.

• next