FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103019102> ?p ?o ?g. }

• W2103019102 abstract "Some monoaminergic neurons can release neurotransmitters by exocytosis from their cell bodies. The amount of monoamine released by somatic exocytosis can be comparable to that released by synaptic exocytosis, though neither the underlying mechanisms nor the functional significance of somatic exocytosis are well understood. A detailed examination of these characteristics may provide new routes for therapeutic intervention in mood disorders, substance addiction, and neurodegenerative diseases. The relatively large size of the cell body provides a unique opportunity to understand the mechanism of this mode of neuronal exocytosis in microscopic detail. Here we used three photon and total internal reflection fluorescence microscopy to focus on the dynamics of the pre-exocytotic events and explore the nature of somatic vesicle storage, transport and docking at the membrane of serotonergic neurons from raphe nuclei of the rat brain. We find that the vesicles (or unresolved vesicular clusters) are quiescent (mean square displacement, MSD ~0.04 μm&#178;/s) before depolarization, and they move minimally (< 1 μm) from their locations over a time scale of minutes. However, within minutes of depolarization, the vesicles become more dynamic (MSD ~0.3 μm&#178;/s), and display larger range (several μm) motions, though without any clear directionality. Docking and subsequent exocytosis at the membrane happen at a timescale (~25 ms) that is slower than most synaptic exocytosis processes, but faster than almost all somatic exocytosis processes observed in endocrine cells. We conclude that, A) depolarization causes de-tethering of the neurotransmitter vesicles from their storage locations, and this constitutes a critical event in somatic exocytosis; B) their subsequent transport kinetics can be described by a process of constrained diffusion, and C) the pre-exocytosis kinetics at the membrane is faster than most other somatic exocytosis processes reported so far." @default.
• W2103019102 created "2016-06-24" @default.
• W2103019102 creator A5044984957 @default.
• W2103019102 creator A5050673217 @default.
• W2103019102 creator A5075374043 @default.
• W2103019102 creator A5082107271 @default.
• W2103019102 creator A5084083373 @default.
• W2103019102 creator A5084411461 @default.
• W2103019102 creator A5089362054 @default.
• W2103019102 date "2012-01-01" @default.
• W2103019102 modified "2023-10-18" @default.
• W2103019102 title "The Dynamics of Somatic Exocytosis in Monoaminergic Neurons" @default.
• W2103019102 cites W1498924480 @default.
• W2103019102 cites W1545683997 @default.
• W2103019102 cites W1582136244 @default.
• W2103019102 cites W1591523569 @default.
• W2103019102 cites W1599906730 @default.
• W2103019102 cites W1724599310 @default.
• W2103019102 cites W1967302106 @default.
• W2103019102 cites W1970130875 @default.
• W2103019102 cites W1972750960 @default.
• W2103019102 cites W1973544245 @default.
• W2103019102 cites W1983078818 @default.
• W2103019102 cites W1990880789 @default.
• W2103019102 cites W1993373202 @default.
• W2103019102 cites W1993645665 @default.
• W2103019102 cites W2000398693 @default.
• W2103019102 cites W2000654807 @default.
• W2103019102 cites W2009759632 @default.
• W2103019102 cites W2010730632 @default.
• W2103019102 cites W2012143436 @default.
• W2103019102 cites W2013907969 @default.
• W2103019102 cites W2023693875 @default.
• W2103019102 cites W2025463284 @default.
• W2103019102 cites W2033888271 @default.
• W2103019102 cites W2035548856 @default.
• W2103019102 cites W2038167599 @default.
• W2103019102 cites W2040799187 @default.
• W2103019102 cites W2047494050 @default.
• W2103019102 cites W2052614942 @default.
• W2103019102 cites W2052699392 @default.
• W2103019102 cites W2056164601 @default.
• W2103019102 cites W2065967745 @default.
• W2103019102 cites W2067319857 @default.
• W2103019102 cites W2068401230 @default.
• W2103019102 cites W2075007264 @default.
• W2103019102 cites W2075183645 @default.
• W2103019102 cites W2077192471 @default.
• W2103019102 cites W2081117049 @default.
• W2103019102 cites W2081478686 @default.
• W2103019102 cites W2083279393 @default.
• W2103019102 cites W2084559690 @default.
• W2103019102 cites W2085941633 @default.
• W2103019102 cites W2088872749 @default.
• W2103019102 cites W2094241937 @default.
• W2103019102 cites W2094558886 @default.
• W2103019102 cites W2096033084 @default.
• W2103019102 cites W2096877591 @default.
• W2103019102 cites W2108982986 @default.
• W2103019102 cites W2114204856 @default.
• W2103019102 cites W2114632806 @default.
• W2103019102 cites W2117474405 @default.
• W2103019102 cites W2123462704 @default.
• W2103019102 cites W2133127985 @default.
• W2103019102 cites W2156568773 @default.
• W2103019102 cites W2163967697 @default.
• W2103019102 cites W2166027728 @default.
• W2103019102 cites W2168748231 @default.
• W2103019102 cites W58356948 @default.
• W2103019102 doi "https://doi.org/10.3389/fphys.2012.00414" @default.
• W2103019102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3490137" @default.
• W2103019102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23133421" @default.
• W2103019102 hasPublicationYear "2012" @default.
• W2103019102 type Work @default.
• W2103019102 sameAs 2103019102 @default.
• W2103019102 citedByCount "18" @default.
• W2103019102 countsByYear W21030191022014 @default.
• W2103019102 countsByYear W21030191022015 @default.
• W2103019102 countsByYear W21030191022017 @default.
• W2103019102 countsByYear W21030191022018 @default.
• W2103019102 countsByYear W21030191022019 @default.
• W2103019102 countsByYear W21030191022020 @default.
• W2103019102 countsByYear W21030191022021 @default.
• W2103019102 countsByYear W21030191022022 @default.
• W2103019102 crossrefType "journal-article" @default.
• W2103019102 hasAuthorship W2103019102A5044984957 @default.
• W2103019102 hasAuthorship W2103019102A5050673217 @default.
• W2103019102 hasAuthorship W2103019102A5075374043 @default.
• W2103019102 hasAuthorship W2103019102A5082107271 @default.
• W2103019102 hasAuthorship W2103019102A5084083373 @default.
• W2103019102 hasAuthorship W2103019102A5084411461 @default.
• W2103019102 hasAuthorship W2103019102A5089362054 @default.
• W2103019102 hasBestOaLocation W21030191021 @default.
• W2103019102 hasConcept C12554922 @default.
• W2103019102 hasConcept C130316041 @default.
• W2103019102 hasConcept C148785051 @default.
• W2103019102 hasConcept C169760540 @default.
• W2103019102 hasConcept C170493617 @default.
• W2103019102 hasConcept C175969161 @default.
• W2103019102 hasConcept C185592680 @default.

• next