FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103025352> ?p ?o ?g. }

• W2103025352 endingPage "165" @default.
• W2103025352 startingPage "157" @default.
• W2103025352 abstract "Abstract —The hypothesis that cellular hypertrophy in congestive heart failure (CHF) modulates mechanosensitive (ie, swelling- or stretch-activated) anion channels was tested. Digital video microscopy and amphotericin-perforated-patch voltage clamp were used to measure cell volume and ion currents in ventricular myocytes isolated from normal dogs and dogs with rapid ventricular pacing-induced CHF. In normal myocytes, osmotic swelling in 0.9T to 0.6T solution (T, relative osmolarity; isosmotic solution, 296 mOsmol/L) was required to elicit I Cl,swell , an outwardly rectifying swelling-activated Cl – current that reversed near –33 mV and was inhibited by 1 mmol/L 9-anthracene carboxylic acid (9AC), an anion channel blocker. Block of I Cl,swell by 9AC simultaneously increased the volume of normal cells in hyposmotic solutions by up to 7%, but 9AC had no effect on volume in isosmotic or hyperosmotic solutions. In contrast, I Cl,swell was persistently activated under isosmotic conditions in CHF myocytes, and 9AC increased cell volume by 9%. Osmotic shrinkage in 1.1T to 1.5T solution inhibited both I Cl,swell and 9AC-induced cell swelling in CHF cells, whereas osmotic swelling only slightly increased I Cl,swell . The current density for fully activated 9AC-sensitive I Cl,swell was 40% greater in CHF than normal myocytes. In both groups, 9AC-sensitive current and 9AC-induced cell swelling were proportional with changes in osmolarity and 9AC concentration, and the effects of 9AC on current and volume were blocked by replacing bath Cl – with methanesulfonate. CHF thus altered the set point and magnitude of I Cl,swell and resulted in its persistent activation. We previously observed analogous regulation of mechanosensitive cation channels in the same CHF model. Mechanosensitive anion and cation channels may contribute to the electrophysiological and contractile derangements in CHF and may be novel targets for therapy." @default.
• W2103025352 created "2016-06-24" @default.
• W2103025352 creator A5003134945 @default.
• W2103025352 creator A5059101841 @default.
• W2103025352 creator A5087876944 @default.
• W2103025352 date "1999-02-05" @default.
• W2103025352 modified "2023-10-15" @default.
• W2103025352 title "Swelling-Activated Chloride Current Is Persistently Activated in Ventricular Myocytes From Dogs With Tachycardia-Induced Congestive Heart Failure" @default.
• W2103025352 cites W121429037 @default.
• W2103025352 cites W1498851698 @default.
• W2103025352 cites W1525632749 @default.
• W2103025352 cites W1577378394 @default.
• W2103025352 cites W1970294642 @default.
• W2103025352 cites W1973105862 @default.
• W2103025352 cites W1973191101 @default.
• W2103025352 cites W1996845076 @default.
• W2103025352 cites W2003453109 @default.
• W2103025352 cites W2003804186 @default.
• W2103025352 cites W2008508150 @default.
• W2103025352 cites W2009262485 @default.
• W2103025352 cites W2013711742 @default.
• W2103025352 cites W2019947010 @default.
• W2103025352 cites W2023869925 @default.
• W2103025352 cites W2028804076 @default.
• W2103025352 cites W2028825267 @default.
• W2103025352 cites W2034842025 @default.
• W2103025352 cites W2039864751 @default.
• W2103025352 cites W2045152040 @default.
• W2103025352 cites W2045986542 @default.
• W2103025352 cites W2073341934 @default.
• W2103025352 cites W2084508206 @default.
• W2103025352 cites W2119443224 @default.
• W2103025352 cites W2136598957 @default.
• W2103025352 cites W2150252960 @default.
• W2103025352 cites W2164313332 @default.
• W2103025352 cites W2255395598 @default.
• W2103025352 cites W2281331275 @default.
• W2103025352 cites W2337735004 @default.
• W2103025352 cites W2409165357 @default.
• W2103025352 cites W2416985692 @default.
• W2103025352 cites W2473630005 @default.
• W2103025352 doi "https://doi.org/10.1161/01.res.84.2.157" @default.
• W2103025352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9933247" @default.
• W2103025352 hasPublicationYear "1999" @default.
• W2103025352 type Work @default.
• W2103025352 sameAs 2103025352 @default.
• W2103025352 citedByCount "96" @default.
• W2103025352 countsByYear W21030253522012 @default.
• W2103025352 countsByYear W21030253522013 @default.
• W2103025352 countsByYear W21030253522014 @default.
• W2103025352 countsByYear W21030253522015 @default.
• W2103025352 countsByYear W21030253522016 @default.
• W2103025352 countsByYear W21030253522018 @default.
• W2103025352 countsByYear W21030253522019 @default.
• W2103025352 countsByYear W21030253522020 @default.
• W2103025352 countsByYear W21030253522021 @default.
• W2103025352 countsByYear W21030253522022 @default.
• W2103025352 countsByYear W21030253522023 @default.
• W2103025352 crossrefType "journal-article" @default.
• W2103025352 hasAuthorship W2103025352A5003134945 @default.
• W2103025352 hasAuthorship W2103025352A5059101841 @default.
• W2103025352 hasAuthorship W2103025352A5087876944 @default.
• W2103025352 hasBestOaLocation W21030253521 @default.
• W2103025352 hasConcept C12554922 @default.
• W2103025352 hasConcept C126322002 @default.
• W2103025352 hasConcept C129900496 @default.
• W2103025352 hasConcept C142724271 @default.
• W2103025352 hasConcept C147944092 @default.
• W2103025352 hasConcept C164705383 @default.
• W2103025352 hasConcept C185263204 @default.
• W2103025352 hasConcept C185592680 @default.
• W2103025352 hasConcept C207200792 @default.
• W2103025352 hasConcept C2778198053 @default.
• W2103025352 hasConcept C2778540859 @default.
• W2103025352 hasConcept C71924100 @default.
• W2103025352 hasConcept C86803240 @default.
• W2103025352 hasConceptScore W2103025352C12554922 @default.
• W2103025352 hasConceptScore W2103025352C126322002 @default.
• W2103025352 hasConceptScore W2103025352C129900496 @default.
• W2103025352 hasConceptScore W2103025352C142724271 @default.
• W2103025352 hasConceptScore W2103025352C147944092 @default.
• W2103025352 hasConceptScore W2103025352C164705383 @default.
• W2103025352 hasConceptScore W2103025352C185263204 @default.
• W2103025352 hasConceptScore W2103025352C185592680 @default.
• W2103025352 hasConceptScore W2103025352C207200792 @default.
• W2103025352 hasConceptScore W2103025352C2778198053 @default.
• W2103025352 hasConceptScore W2103025352C2778540859 @default.
• W2103025352 hasConceptScore W2103025352C71924100 @default.
• W2103025352 hasConceptScore W2103025352C86803240 @default.
• W2103025352 hasIssue "2" @default.
• W2103025352 hasLocation W21030253521 @default.
• W2103025352 hasLocation W21030253522 @default.
• W2103025352 hasLocation W21030253523 @default.
• W2103025352 hasOpenAccess W2103025352 @default.
• W2103025352 hasPrimaryLocation W21030253521 @default.
• W2103025352 hasRelatedWork W1966003326 @default.
• W2103025352 hasRelatedWork W2001973908 @default.
• W2103025352 hasRelatedWork W2003526108 @default.

• next