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• W2103046543 abstract "Abstract Patients with human papillomavirus DNA positive ( HPV DNA +) oropharyngeal squamous cell carcinoma ( OSCC ) have better clinical outcome than those with HPV DNA negative ( HPV DNA −) OSCC upon intensive oncological treatment. All HPV DNA + OSCC patients may not require intensive treatment, however, but before potentially deintensifying treatment, additional predictive markers are needed. Here, we examined HPV , p16 INK4a , and CD 44 in OSCC in correlation to clinical outcome. Pretreatment tumors from 290 OSCC patients, the majority not receiving chemotherapy, were analyzed for HPV DNA by Luminex and for p16 INK4a and CD 44 by immunohistochemistry. 225/290 (78%) tumors were HPV DNA + and 211/290 (73%) overexpressed p16 INK4a , which correlated to presence of HPV ( P < 0.0001). Presence of HPV DNA , absent/weak CD 44 intensity staining correlated to favorable 3‐year disease‐free survival ( DFS ) and overall survival ( OS ) by univariate and multivariate analysis, and likewise for p16 INK4a by univariate analysis. Upon stratification for HPV , HPV DNA + OSCC with absent/weak CD 44 intensity presented the significantly best 3‐year DFS and OS , with >95% 3‐year DFS and OS . Furthermore, in HPV DNA + OSCC , p16 INK4a + overexpression correlated to a favorable 3‐year OS . In conclusion, patients with HPV DNA + and absent/weak CD 44 intensity OSCC presented the best survival and this marker combination could possibly be used for selecting patients for tailored deintensified treatment in prospective clinical trials." @default.
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• W2103046543 date "2013-06-14" @default.
• W2103046543 modified "2023-10-16" @default.
• W2103046543 title "Absent/weak <scp>CD</scp> 44 intensity and positive human papillomavirus ( <scp>HPV</scp> ) status in oropharyngeal squamous cell carcinoma indicates a very high survival" @default.
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• W2103046543 doi "https://doi.org/10.1002/cam4.90" @default.
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