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• W2103059589 abstract "ABSTRACT In spite of the present belief that latent cytomegalovirus (CMV) infection drives CD8 + T-cell differentiation and induces premature immune senescence, no systematic studies have so far been performed to compare phenotypical and functional changes in the CD8 + T-cell repertoire in CMV-infected and noninfected persons of different age groups. In the present study, number, cytokine production, and growth potential of naïve (CD45RA + CD28 + ), memory (CD45RA − CD28 + ), and effector (CD45RA + CD28 − or CD45RA − CD28 − ) CD8 + T cells were analyzed in young, middle-aged, and elderly clinically healthy persons with a positive or negative CMV antibody serology. Numbers and functional properties of CMVpp65 495-503 -specific CD8 + T cells were also studied. We demonstrate that aging as well as CMV infection lead to a decrease in the size of the naïve CD8 + T-cell pool but to an increase in the number of CD8 + effector T cells, which produce gamma interferon but lack substantial growth potential. The size of the CD8 + memory T-cell population, which grows well and produces interleukin-2 (IL-2) and IL-4, also increases with aging, but this increase is missing in CMV carriers. Life-long latent CMV infection seems thus to diminish the size of the naïve and the early memory T-cell pool and to drive a Th1 polarization within the immune system. This can lead to a reduced diversity of CD8 responses and to chronic inflammatory processes which may be the basis of severe health problems in elderly persons." @default.
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• W2103059589 date "2005-03-15" @default.
• W2103059589 modified "2023-10-17" @default.
• W2103059589 title "Long-Term Cytomegalovirus Infection Leads to Significant Changes in the Composition of the CD8⁺T-Cell Repertoire, Which May Be the Basis for an Imbalance in the Cytokine Production Profile in Elderly Persons" @default.
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• W2103059589 doi "https://doi.org/10.1128/jvi.79.6.3675-3683.2005" @default.
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