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- W2103068351 abstract "We have explored the role of the human NANOS3 gene in lung tumour progression. We show that NANOS3 is over-expressed by invasive lung cancer cells and is a prognostic marker for non-small cell lung carcinomas (NSCLCs). NANOS3 gene expression is restricted in testis and brain and is regulated by epigenetic events. It is up-regulated in cultured cells undergoing epithelial - mesenchymal transition (EMT). NANOS3 over-expression in human NSCLC cell lines enhances their invasiveness by up-regulating EMT, whereas its silencing induces mesenchymal - epithelial transition. NANOS3 represses E-cadherin at the transcriptional level and up-regulates vimentin post-transcriptionally. Also, we show that NANOS3 binds mRNAs encoding vimentin and regulates the length of their poly(A) tail. Finally, NANOS3 can also protect vimentin mRNA from microRNA-mediated repression. We thus demonstrate a role for NANOS3 in the acquisition of invasiveness by human lung tumour cells and propose a new mechanism of post-transcriptional regulation of EMT." @default.
- W2103068351 created "2016-06-24" @default.
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- W2103068351 date "2015-05-12" @default.
- W2103068351 modified "2023-10-06" @default.
- W2103068351 title "The human<i>NANOS3</i>gene contributes to lung tumour invasion by inducing epithelial-mesenchymal transition" @default.
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- W2103068351 doi "https://doi.org/10.1002/path.4549" @default.
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