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• W2103071432 abstract "Context: Measurements of the 3-O-methylated metabolites of catecholamines [metanephrines (MNs)] in plasma or urine are recommended for diagnosis of pheochromocytoma. It is unclear whether these tests are susceptible to dietary influences. Objective: The aim of the study was to determine the short-term influence of a catecholamine-rich diet on plasma and urinary fractionated MNs. Design, Setting, and Participants: We conducted a crossover study in a specialist medical center involving 26 healthy adults. Interventions: Subjects consumed catecholamine-rich nuts and fruits at fixed times on one day (about 35 μmol dopamine and 1 μmol norepinephrine) and catecholamine-poor products on another day. Blood and urine samples were collected at timed intervals before, during, and after experimental and control interventions. Main Outcome Measures: Isotope-dilution mass spectrometry-based measurements of plasma and urinary concentrations of free and deconjugated 3-methoxytyramine (3-MT), normetanephrine (NMN), and MN were made. Results: The catecholamine-rich diet had substantial effects (up to 3-fold increases) on plasma concentrations and urinary outputs of free and deconjugated 3-MT. Dietary catecholamines had negligible influences on free NMN in plasma and urine, but substantial effects (up to 2-fold increases) on deconjugated NMN in plasma and urine. Concentrations of free and deconjugated MN in plasma and urine remained unaffected. Conclusions: Dietary restrictions should be considered to minimize false-positive results for urinary and plasma deconjugated MNs during diagnosis of pheochromocytoma. Similar considerations appear warranted for plasma and urinary free 3-MT, but not for free NMN or MN, indicating advantages of measurements of the free compared to deconjugated metabolites." @default.
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• W2103071432 date "2009-08-01" @default.
• W2103071432 modified "2023-09-30" @default.
• W2103071432 title "Dietary Influences on Plasma and Urinary Metanephrines: Implications for Diagnosis of Catecholamine-Producing Tumors" @default.
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• W2103071432 doi "https://doi.org/10.1210/jc.2009-0303" @default.
• W2103071432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19567530" @default.
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